Search Results - "Fardilha, M"

Stress response pathways in the male germ cells and gametes by Santiago, J, Santos, M A S, Fardilha, M, Silva, J V

“…The unfolded protein response (UPR) is a conserved and essential cellular pathway involved in protein quality control that is activated in response to several…”
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Isoform-specific GSK3A activity is negatively correlated with human sperm motility by Freitas, M J, Silva, J V, Brothag, C, Regadas-Correia, B, Fardilha, M, Vijayaraghavan, S

“…Abstract In mouse and bovine sperm, GSK3 activity is inversely proportional to motility. Targeted disruption of the GSK3A gene in testis results in normal…”
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Understanding prostate cancer biology using metabolomics and proteomics approaches: potentials in the improvement of the diagnosis, prognosis and identification of new therapeutic targets by Felgueiras, J, Vieira Silva, J, Nunes, A, Patrício, A, Pelech, S, Fardilha, M

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From proteomic to therapeutic analysis: functional profile of two lung cancer cell lines widely studied in pre-clinical research by Korrodi-Gregório, L, Soto-Cerrato, V, Vitorino, R, Fardilha, M, Pérez-Tomás, R

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The physiological relevance of protein phosphatase 1 and its interacting proteins to health and disease by Fardilha, M, Esteves, S L C, Korrodi-Gregório, L, da Cruz e Silva, O A B, da Cruz e Silva, F F

“…Protein phosphorylation is a major regulatory mechanism of signal transduction cascades in eukaryotic cells, catalysed by kinases and reversed by protein…”
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P-115 The ageing sperm: molecular mechanisms underlying the age-associated decline in human sperm quality by Santiago, J, Silva, J.V, Santos, M.A.S, Fardilha, M

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Understanding fatty acid metabolism through an active learning approach by Fardilha, M., Schrader, M., da Cruz e Silva, O. A. B., da Cruz e Silva, E. F.

“…A multi‐method active learning approach (MALA) was implemented in the Medical Biochemistry teaching unit of the Biomedical Sciences degree at the University of…”
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2180 - Understanding prostate cancer biology using metabolomics and proteomics approaches: potentials in the improvement of the diagnosis, prognosis and identification of new therapeutic targets by Felgueiras, J., Vieira Silva, J., Nunes, A., Patrício, A., Pelech, S., Fardilha, M.

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748 - From proteomic to therapeutic analysis: functional profile of two lung cancer cell lines widely studied in pre-clinical research by Korrodi-Gregório, L., Soto-Cerrato, V., Vitorino, R., Fardilha, M., Pérez-Tomás, R.

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Protein phosphatase 1 complexes modulate sperm motility and present novel targets for male infertility by Fardilha, Margarida, Esteves, Sara L.C., Korrodi-Gregório, Luís, Pelech, Steven, da Cruz e Silva, Odete A.B., da Cruz e Silva, Edgar

“…Infertility is a growing concern in modern society, with 30% of cases being due to male factors, namely reduced sperm concentration, decreased motility and…”
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Protein phosphatase 1α interacting proteins in the human brain by Esteves, Sara L C, Domingues, Sara C, da Cruz e Silva, Odete A B, Fardilha, Margarida, da Cruz e Silva, Edgar F

“…Protein Phosphatase 1 (PP1) is a major serine/threonine-phosphatase whose activity is dependent on its binding to regulatory subunits known as PP1 interacting…”
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Alternatively Spliced Protein Variants as Potential Therapeutic Targets for Male Infertility and Contraception by FARDILHA, MARGARIDA, WU, WENJUAN, SÁ, ROSÁLIA, FIDALGO, SARA, SOUSA, CRISTINA, MOTA, CATARINA, DA CRUZ E SILVA, ODETE A.B., DA CRUZ E SILVA, EDGAR F.

“…: Mammalian sperm were previously shown to express the PP1γ2 isoform of protein phosphatase 1 (PP1) as well as its regulatory proteins inhibitor 2 and glycogen…”
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SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein by Browne, Gareth J, Fardilha, Margarida, Oxenham, Senga K, Wu, Wenjuan, Helps, Nicholas R, da Cruz E Silva, Odete A B, Cohen, Patricia T W, da Cruz E Silva, Edgar F

“…PP1 (protein phosphatase 1) is a ubiquitously expressed serine/threonine-specific protein phosphatase whose activity towards different substrates appears to be…”
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Signal transduction therapeutics: relevance for Alzheimer's disease by da Cruz e Silva, Odete A B, Fardilha, Margarida, Henriques, Ana Gabriela, Rebelo, Sandra, Vieira, Sandra, da Cruz e Silva, Edgar F

“…It is now widely accepted that abnormal processing of the Alzheimer's amyloid precursor protein (APP) can contribute significantly to Alzheimer's disease (AD)…”
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Profiling signaling proteins in human spermatozoa: Biomarker identification for sperm quality evaluation by Freitas, M.J., Correia, B.R., Korrodi-Gregório, L., Patrício, A., Pelech, S., Silva, J.V., Fardilha, M.

“…In this study we unraveled human spermatozoa signaling pathways and correlated the activity of sperm signaling proteins with clinical data. Thirty seven semen…”
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Physicians versus surgeons. A pilot study on hand dexterity within a controlled population by Figueiredo, S, Machado, L, Lousada, A D P, Castelo, L S, Fardilha, M L, Sa, A

“…Hand dexterity is defined as the innate or acquired capacity of performing any given procedure with one's hands. This study seeks the role of regular hand…”
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