Search Results - "Farde, Lars"

Nigrostriatal dopamine transporter availability in early Parkinson's disease by Fazio, Patrik, Svenningsson, Per, Cselényi, Zsolt, Halldin, Christer, Farde, Lars, Varrone, Andrea

“…ABSTRACT Background: The imaging of biomarkers for characterization of dopaminergic impairment in Parkinson's disease (PD) is useful for diagnosis, patient…”
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Quantification of Blood Flow-Dependent Component in Estimates of Beta-Amyloid Load Obtained Using Quasi-Steady-State Standardized Uptake Value Ratio by Cselényi, Zsolt, Farde, Lars

“…Longitudinal positron emission tomography (PET) imaging of beta-amyloid is used in basic research and in drug efficacy trials in Alzheimer's disease (AD)…”
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Serotonin transporter availability in adults with autism—a positron emission tomography study by Andersson, Max, Tangen, Ämma, Farde, Lars, Bölte, Sven, Halldin, Christer, Borg, Jacqueline, Lundberg, Johan

“…Impairments in social interaction and communication, in combination with restricted, repetitive behaviors and interests, define the neurodevelopmental…”
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Antipsychotic Occupancy of Dopamine Receptors in Schizophrenia by Nord, Magdalena, Farde, Lars

“…SUMMARY Antipsychotic drugs were introduced in the early 50s on the basis of clinical observations in patients with schizophrenia. Experimental studies later…”
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Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease by Jucaite, Aurelija, Svenningsson, Per, Rinne, Juha O, Cselényi, Zsolt, Varnäs, Katarina, Johnström, Peter, Amini, Nahid, Kirjavainen, Anna, Helin, Semi, Minkwitz, Margaret, Kugler, Alan R, Posener, Joel A, Budd, Samantha, Halldin, Christer, Varrone, Andrea, Farde, Lars

“…Impaired mitochondrial function, oxidative stress and formation of excessive levels of reactive oxygen species play a key role in neurodegeneration in…”
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Brain neuroreceptor density and personality traits: towards dimensional biomarkers for psychiatric disorders by Farde, Lars, Plavén-Sigray, Pontus, Borg, Jacqueline, Cervenka, Simon

“…Positron emission tomography has, for 30 years, been used in numerous case-control studies searching for hypothesized differences in the density of…”
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Validity and reliability of extrastriatal [11C]raclopride binding quantification in the living human brain by Svensson, Jonas E., Schain, Martin, Plavén-Sigray, Pontus, Cervenka, Simon, Tiger, Mikael, Nord, Magdalena, Halldin, Christer, Farde, Lars, Lundberg, Johan

“…[11C]raclopride is a well established PET tracer for the quantification of dopamine 2/3 receptors (D2/3R) in the striatum. Outside of the striatum the receptor…”
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Low convergent validity of [11C]raclopride binding in extrastriatal brain regions: A PET study of within-subject correlations with [11C]FLB 457 by Freiburghaus, Tove, Svensson, Jonas E., Matheson, Granville J., Plavén-Sigray, Pontus, Lundberg, Johan, Farde, Lars, Cervenka, Simon

“…Dopamine D2 receptors (D2-R) in extrastriatal brain regions are of high interest for research in a wide range of psychiatric and neurologic disorders…”
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The correlative triad among aging, dopamine, and cognition: Current status and future prospects by Bäckman, Lars, Nyberg, Lars, Lindenberger, Ulman, Li, Shu-Chen, Farde, Lars

“…The brain neuronal systems defined by the neurotransmitter dopamine (DA) have since long a recognized role in the regulation of motor functions. More recently,…”
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High-resolution PET imaging reveals subtle impairment of the serotonin transporter in an early non-depressed Parkinson’s disease cohort by Fazio, Patrik, Ferreira, Daniel, Svenningsson, Per, Halldin, Christer, Farde, Lars, Westman, Eric, Varrone, Andrea

“…Purpose The serotonin transporter (SERT) is a biochemical marker for monoaminergic signaling in brain and has been suggested to be involved inthe…”
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D1-Dopamine Receptor Availability in First-Episode Neuroleptic Naive Psychosis Patients by Stenkrona, Per, Matheson, Granville J, Halldin, Christer, Cervenka, Simon, Farde, Lars

“…Positron emission tomography studies examining differences in D1-dopamine receptor binding between control subjects and patients with schizophrenia have been…”
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Performance evaluation of the small-animal nanoScan PET/MRI system by Nagy, Kálmán, Tóth, Miklós, Major, Péter, Patay, Gergely, Egri, Gyozo, Häggkvist, Jenny, Varrone, Andrea, Farde, Lars, Halldin, Christer, Gulyás, Balázs

“…nanoScan is a high-resolution integrated system for consecutive PET and MR imaging of small laboratory animals. We evaluated the performance of the system,…”
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The immune response of the human brain to abdominal surgery by Forsberg, Anton, Cervenka, Simon, Jonsson Fagerlund, Malin, Rasmussen, Lars S., Zetterberg, Henrik, Erlandsson Harris, Helena, Stridh, Pernilla, Christensson, Eva, Granström, Anna, Schening, Anna, Dymmel, Karin, Knave, Nina, Terrando, Niccolò, Maze, Mervyn, Borg, Jacqueline, Varrone, Andrea, Halldin, Christer, Blennow, Kaj, Farde, Lars, Eriksson, Lars I.

“…Objective Surgery launches a systemic inflammatory reaction that reaches the brain and associates with immune activation and cognitive decline. Although…”
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Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis by Plavén-Sigray, Pontus, Ikonen Victorsson, Pauliina, Santillo, Alexander, Matheson, Granville J., Lee, Maria, Collste, Karin, Fatouros-Bergman, Helena, Sellgren, Carl M., Erhardt, Sophie, Agartz, Ingrid, Halldin, Christer, Farde, Lars, Cervenka, Simon

“…Pharmacological and genetic evidence support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous…”
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Kinfitr — an open-source tool for reproducible PET modelling: validation and evaluation of test-retest reliability by Tjerkaski, Jonathan, Cervenka, Simon, Farde, Lars, Matheson, Granville James

“…Background In positron emission tomography (PET) imaging, binding is typically estimated by fitting pharmacokinetic models to the series of measurements of…”
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Application of cross-species PET imaging to assess neurotransmitter release in brain by Finnema, Sjoerd J., Scheinin, Mika, Shahid, Mohammed, Lehto, Jussi, Borroni, Edilio, Bang-Andersen, Benny, Sallinen, Jukka, Wong, Erik, Farde, Lars, Halldin, Christer, Grimwood, Sarah

“…Rationale This review attempts to summarize the current status in relation to the use of positron emission tomography (PET) imaging in the assessment of…”
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Diurnal and seasonal variation of the brain serotonin system in healthy male subjects by Matheson, Granville J, Schain, Martin, Almeida, Rita, Lundberg, Johan, Cselényi, Zsolt, Borg, Jacqueline, Varrone, Andrea, Farde, Lars, Cervenka, Simon

“…The mammalian circadian clock underlies both diurnal and seasonal changes in physiology, and its function is thought to be disturbed in both seasonal and…”
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Effect of a single dose of escitalopram on serotonin concentration in the non-human and human primate brain by Nord, Magdalena, Finnema, Sjoerd J., Halldin, Christer, Farde, Lars

“…Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for treatment of psychiatric disorders. The exact mechanism underlying the clinical…”
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Individual differences in the proneness to have flow experiences are linked to dopamine D2-receptor availability in the dorsal striatum by de Manzano, Örjan, Cervenka, Simon, Jucaite, Aurelija, Hellenäs, Oscar, Farde, Lars, Ullén, Fredrik

“…Flow is a subjective experience of high but effortless attention, enjoyment, and low self-awareness that can occur during the active performance of challenging…”
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Dopamine D1 receptors and age differences in brain activation during working memory by Bäckman, Lars, Karlsson, Sari, Fischer, Håkan, Karlsson, Per, Brehmer, Yvonne, Rieckmann, Anna, MacDonald, Stuart W.S, Farde, Lars, Nyberg, Lars

“…Abstract In an fMRI study, 20 younger and 20 healthy older adults were scanned while performing a spatial working-memory task under two levels of load. On a…”
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