Search Results - "Farb, DH"

Combined administration of levetiracetam and valproic acid attenuates age-related hyperactivity of CA3 place cells, reduces place field area, and increases spatial information content in aged rat hippocampus by Robitsek, Jonathan, Ratner, Marcia H., Stewart, Tara, Eichenbaum, Howard, Farb, David H.

“…ABSTRACT Learning and memory deficits associated with age‐related mild cognitive impairment have long been attributed to impaired processing within the…”
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Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids by Malayev, Andrew, Gibbs, Terrell T, Farb, David H

“…The neurosteroid pregnenolone sulphate (PS) potentiates N‐methyl‐D‐aspartate (NMDA) receptor mediated responses in various neuronal preparations. The NR1…”
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Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator by Lippa, A, Czobor, P, Stark, J, Beer, B, Kostakis, E, Gravielle, M, Bandyopadhyay, S, Russek, S J, Gibbs, T T, Farb, D H, Skolnick, P

“…Benzodiazepines remain widely used for the treatment of anxiety disorders despite prominent, often limiting side effects including sedation, muscle relaxation,…”
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Sulfated and unsulfated steroids modulate γ-aminobutyric acid A receptor function through distinct sites by Park-Chung, Mijeong, Malayev, Andrew, Purdy, Robert H., Gibbs, Terrell T., Farb, David H.

“…Sulfated and unsulfated neurosteroids such as pregnenolone sulfate, dehydroepiandrosterone sulfate (DHEAS), pregnanolone, and allopregnanolone, modulate…”
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Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation by Downing, Scott S, Lee, Yan T, Farb, David H, Gibbs, Terrell T

“…Benzodiazepines (BZDs) have been used extensively for more than 40 years because of their high therapeutic index and low toxicity. Although BZDs are understood…”
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17 beta -Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors by Weaver, CE Jr, Park-Chung, Mijeong, Gibbs, T T, Farb, D H

“…Several lines of evidence suggest that 17 beta -estradiol ( beta E2) has neuroprotective properties. The risk and severity of dementia are decreased in women…”
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A Steroid Modulatory Domain on NR2B Controls N-Methyl-D-Aspartate Receptor Proton Sensitivity by Jang, Ming-Kuei, Mierke, Dale F., Russek, Shelley J., Farb, David H., Costa, Erminio

“…N-methyl-D-aspartate (NMDA) receptor function is modulated by several endogenous molecules, including zinc, polyamines, protons, and sulfated neurosteroids…”
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Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids by Park-Chung, M, Wu, F S, Purdy, R H, Malayev, A A, Gibbs, T T, Farb, D H

“…Steroid sulfation occurs in nervous tissue and endogenous sulfated steroids can act as positive or negative modulators of N-methyl-D-aspartate (NMDA) receptor…”
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Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor by Wu, F S, Gibbs, T T, Farb, D H

“…The N-methyl-D-aspartate (NMDA) receptor is believed to play a major role in learning and in excitotoxic neuronal damage associated with stroke and epilepsy…”
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An Initiator Element Mediates Autologous down-Regulation of the Human Type A γ -Aminobutyric Acid Receptor β 1 Subunit Gene by Russek, Shelley J., Bandyopadhyay, Sabita, Farb, David H.

“…The regulated expression of type A γ -aminobutyric acid receptor (GABAAR) subunit genes is postulated to play a role in neuronal maturation, synaptogenesis,…”
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Human GABA(B)R genomic structure: evidence for splice variants in GABA(B)R1 but not GABA(B)R2 by Martin, S C, Russek, S J, Farb, D H

“…The type B gamma-aminobutryic acid receptor (GABA(B)R) is a G protein coupled receptor that mediates slow pre- and post-synaptic inhibition in the nervous…”
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Neuroprotective Activity of a New Class of Steroidal Inhibitors of the N-Methyl-D-Aspartate Receptor by Weaver, Charles E., Marek, Przemyslaw, Park-Chung, Mijeong, Tam, S. William, Farb, David H.

“…Release of the excitatory neurotransmitter glutamate and the excessive stimulation of N-methyl-D-aspartate (NMDA)-type glutamate receptors is thought to be…”
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Distinct signal transduction pathways for GABA-induced GABA(A) receptor down-regulation and uncoupling in neuronal culture: a role for voltage-gated calcium channels by Lyons, H R, Land, M B, Gibbs, T T, Farb, D H

“…Changes in GABA receptor (GABA(A)R) gene expression are detected in animal models of epilepsy, anxiety and in post-mortem schizophrenic brain, suggesting a…”
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Prenatal protein malnutrition reduces beta(2), beta(3) and gamma(2L) GABA(A) receptor subunit mRNAs in the adult septum by Steiger, Janine L, Galler, Janina R, Farb, David H, Russek, Shelley J

“…Rats exposed to prenatal protein malnutrition are less sensitive to the amnestic effects of chlordiazepoxide when administered directly into the medial septum…”
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Differential expression of γ-aminobutyric acid type B receptor subunit mRNAs in the developing nervous system and receptor coupling to adenylyl cyclase in embryonic neurons by Martin, Stella C., Steiger, Janine L., Gravielle, María Clara, Lyons, Helen R., Russek, Shelley J., Farb, David H.

“…γ‐Aminobutyric acid type B receptors (GABABRs) mediate both slow inhibitory synaptic activity in the adult nervous system and motility signals for migrating…”
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3 alpha-Hydroxy-5 beta-pregnan-20-one sulfate: a negative modulator of the NMDA-induced current in cultured neurons by Park-Chung, M, Wu, F S, Farb, D H

“…We have shown previously that the neurosteroid pregnenolone sulfate acts as a positive allosteric modulator at the N-methyl-D-aspartate (NMDA) receptor while…”
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Neurosteroid modulation of recombinant ionotropic glutamate receptors by Yaghoubi, Nader, Malayev, Andrew, Russek, Shelley J, Gibbs, Terrell T, Farb, David H

“…Pregnenolone sulfate (PS) is an abundant neurosteroid that can potentiate or inhibit ligand gated ion channel activity and thereby alter neuronal excitability…”
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γ-Aminobutyric acid A receptor regulation: heterologous uncoupling of modulatory site interactions induced by chronic steroid, barbiturate, benzodiazepine, or GABA treatment in culture by Friedman, Linda K., Gibbs, Terrell T., Farb, David H.

“…Prolonged administration of anxiolytic, sedative, and anticonvulsant drugs that act through the GABA A receptor (GAB AR) can evoke tolerance and dependence,…”
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Inhibition of NMDA‐induced striatal dopamine release and behavioral activation by the neuroactive steroid 3α‐hydroxy‐5β‐pregnan‐20‐one hemisuccinate by Sadri‐Vakili, G., Johnson, D. W., Janis, G. C., Gibbs, T. T., Pierce, R. C., Farb, D. H.

“…Our laboratory has previously shown that the synthetic neuroactive steroid 3α‐hydroxy‐5β‐pregnan‐20‐one hemisuccinate (3α5βHS) is a negative modulator of NMDA…”
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Pregnenolone sulfate exacerbates NMDA-induced death of hippocampal neurons by Weaver, Charles E, Wu, Fong-Sen, Gibbs, Terrell T, Farb, David H

“…Excessive stimulation of the N-methyl- d-aspartate (NMDA)-type glutamate receptor has been implicated in the neuronal death resulting from focal…”
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