Search Results - "Farb, D H"

Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator by Lippa, A, Czobor, P, Stark, J, Beer, B, Kostakis, E, Gravielle, M, Bandyopadhyay, S, Russek, S J, Gibbs, T T, Farb, D H, Skolnick, P

“…Benzodiazepines remain widely used for the treatment of anxiety disorders despite prominent, often limiting side effects including sedation, muscle relaxation,…”
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Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes by Eagleson, K.L, Gravielle, M.C, Schlueter McFadyen-Ketchum, L.J, Russek, S.J, Farb, D.H, Levitt, P

“…Abstract Disruption of the GABAergic system has been implicated in multiple developmental disorders, including epilepsy, autism spectrum disorder and…”
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Nanomolar concentrations of pregnenolone sulfate enhance striatal dopamine overflow in vivo by Sadri-Vakili, G, Janis, G C, Pierce, R C, Gibbs, T T, Farb, D H

“…The balance between GABA-mediated inhibitory and glutamate-mediated excitatory synaptic transmission represents a fundamental mechanism for controlling nervous…”
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Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor by Wu, F S, Gibbs, T T, Farb, D H

“…The N-methyl-D-aspartate (NMDA) receptor is believed to play a major role in learning and in excitotoxic neuronal damage associated with stroke and epilepsy…”
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Inhibition of NMDA‐induced striatal dopamine release and behavioral activation by the neuroactive steroid 3α‐hydroxy‐5β‐pregnan‐20‐one hemisuccinate by Sadri‐Vakili, G., Johnson, D. W., Janis, G. C., Gibbs, T. T., Pierce, R. C., Farb, D. H.

“…Our laboratory has previously shown that the synthetic neuroactive steroid 3α‐hydroxy‐5β‐pregnan‐20‐one hemisuccinate (3α5βHS) is a negative modulator of NMDA…”
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Inverse modulation of gamma-aminobutyric acid- and glycine-induced currents by progesterone by Wu, F S, Gibbs, T T, Farb, D H

“…The ability of certain synthetic and endogenous steroids to modulate neuronal responses to gamma-aminobutyric acid (GABA) is well documented, but little is…”
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3 alpha-Hydroxy-5 beta-pregnan-20-one sulfate: a negative modulator of the NMDA-induced current in cultured neurons by Park-Chung, M, Wu, F S, Farb, D H

“…We have shown previously that the neurosteroid pregnenolone sulfate acts as a positive allosteric modulator at the N-methyl-D-aspartate (NMDA) receptor while…”
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Neurosteroid modulation of recombinant ionotropic glutamate receptors by Yaghoubi, Nader, Malayev, Andrew, Russek, Shelley J, Gibbs, Terrell T, Farb, David H

“…Pregnenolone sulfate (PS) is an abundant neurosteroid that can potentiate or inhibit ligand gated ion channel activity and thereby alter neuronal excitability…”
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Gamma-aminobutyric acidA receptor regulation: chronic treatment with pregnanolone uncouples allosteric interactions between steroid and benzodiazepine recognition sites by Friedman, L, Gibbs, T T, Farb, D H

“…Pregnanolone [5 beta-pregnan-3 alpha-ol-20-one (5 beta 3 alpha)] and allopregnanolone [5 alpha-pregnan-3 alpha-ol-20-one (5 alpha 3 alpha)] are neuroactive…”
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"Run-down" of gamma-aminobutyric acidA receptor function during whole-cell recording: a possible role for phosphorylation by Gyenes, M, Farrant, M, Farb, D H

“…When using whole-cell recording methods and a minimal intracellular medium containing only inorganic ions, ethyleneglycolbis-(beta-aminoethyl…”
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Negative modulation of the gamma-aminobutyric acid response by extracellular zinc by Celentano, J J, Gyenes, M, Gibbs, T T, Farb, D H

“…We have studied the effects of divalent cations on the gamma-aminobutyric acid (GABA) response of voltage-clamped spinal cord neurons, using the whole-cell…”
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Pregnenolone sulfate exacerbates NMDA-induced death of hippocampal neurons by Weaver, Charles E, Wu, Fong-Sen, Gibbs, Terrell T, Farb, David H

“…Excessive stimulation of the N-methyl- d-aspartate (NMDA)-type glutamate receptor has been implicated in the neuronal death resulting from focal…”
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Phosphorylation factors control neurotransmitter and neuromodulator actions at the gamma-aminobutyric acid type A receptor by Gyenes, M, Wang, Q, Gibbs, T T, Farb, D H

“…Whole-cell and patch-voltage clamp experiments were carried out on cultured chick spinal cord neurons to investigate the dependence of gamma-aminobutyric acid…”
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Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular Ca2+ in cultured rat hippocampal neurons by Irwin, R P, Maragakis, N J, Rogawski, M A, Purdy, R H, Farb, D H, Paul, S M

“…The ability of the neuroactive steroid pregnenolone sulfate to alter N-methyl-D-aspartate (NMDA) receptor-mediated elevations in intracellular Ca2+ ([Ca2+]i)…”
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Chronic agonist exposure induces down-regulation and allosteric uncoupling of the gamma-aminobutyric acid/benzodiazepine receptor complex by Roca, D J, Rozenberg, I, Farrant, M, Farb, D H

“…Using [3H]flunitrazepam as a probe for the benzodiazepine-sensitive modulator site located on the gamma-aminobutyric acid (GABA)A receptor complex, we have…”
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gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines by Roca, D J, Schiller, G D, Friedman, L, Rozenberg, I, Gibbs, T T, Farb, D H

“…In previous reports, we have described the use of primary neuronal cultures derived from chick brain to study the regulation of the gamma-aminobutyric acidA…”
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17 beta -Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors by Weaver, CE Jr, Park-Chung, Mijeong, Gibbs, T T, Farb, D H

“…Several lines of evidence suggest that 17 beta -estradiol ( beta E2) has neuroprotective properties. The risk and severity of dementia are decreased in women…”
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Modulation of neurotransmitter receptor desensitization: chlordiazepoxide stimulates fading of the GABA response by Mierlak, D, Farb, DH

“…Benzodiazepines are neuromodulatory drugs that potentiate GABA-mediated conductance increases. We report the findings of an investigation into the effect of a…”
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Modulation of neurotransmitter action: control of the gamma- aminobutyric acid response through the benzodiazepine receptor by Chan, CY, Farb, DH

“…The ability of several homologous benzodiazepine and heterologous nonbenzodiazepine ligands to alter the conductance increase induced in spinal cord neurons by…”
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Mechanism of gamma-aminobutyric acid/benzodiazepine receptor turnover in neuronal cells: evidence for nonlysosomal degradation by Borden, L A, Farb, D H

“…In a previous report we described the use of flunitrazepam as a photoaffinity label to monitor the turnover of the gamma-aminobutyric acid/benzodiazepine…”
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