Search Results - "Faraj, Santiago E."

Human Frataxin Folds Via an Intermediate State. Role of the C-Terminal Region by Faraj, Santiago E., González-Lebrero, Rodolfo M., Roman, Ernesto A., Santos, Javier

“…The aim of this study is to investigate the folding reaction of human frataxin, whose deficiency causes the neurodegenerative disease Friedreich’s Ataxia…”
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Protein stability and dynamics modulation: the case of human frataxin by Roman, Ernesto A, Faraj, Santiago E, Gallo, Mariana, Salvay, Andres G, Ferreiro, Diego U, Santos, Javier

“…Frataxin (FXN) is an α/β protein that plays an essential role in iron homeostasis. Apparently, the function of human FXN (hFXN) depends on the cooperative…”
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Measurements of Na+-occluded intermediates during the catalytic cycle of the Na+/K+-ATPase provide novel insights into the mechanism of Na+ transport by Faraj, Santiago E., Valsecchi, Wanda M., Ferreira-Gomes, Mariela, Centeno, Mercedes, Saint Martin, Elina Malén, Fedosova, Natalya U., Rossi, Juan Pablo FC, Montes, Mónica R., Rossi, Rolando C.

“…The Na+/K+-ATPase is an integral plasma membrane glycoprotein of all animal cells that couples the exchange of intracellular Na+ for extracellular K+ to the…”
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Author Correction: Global Implications of Local Unfolding Phenomena, Probed by Cysteine Reactivity in Human Frataxin by Faraj, Santiago E., Noguera, Martín E., Delfino, José María, Santos, Javier

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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The alteration of the C‐terminal region of human frataxin distorts its structural dynamics and function by Faraj, Santiago E., Roman, Ernesto A., Aran, Martin, Gallo, Mariana, Santos, Javier

“…Friedreich's ataxia (FRDA) is linked to a deficiency of frataxin (FXN), a mitochondrial protein involved in iron‐sulfur cluster synthesis. FXN is a small…”
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Global Implications of Local Unfolding Phenomena, Probed by Cysteine Reactivity in Human Frataxin by Faraj, Santiago E., Noguera, Martín E., Delfino, José María, Santos, Javier

“…Local events that affect specific regions of proteins are of utmost relevance for stability and function. The aim of this study is to quantitatively assess the…”
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Frataxin from Psychromonas ingrahamii as a model to study stability modulation within the CyaY protein family by Roman, Ernesto A., Faraj, Santiago E., Cousido-Siah, Alexandra, Mitschler, André, Podjarny, Alberto, Santos, Javier

“…Adaptation of life to low temperatures influences both protein stability and flexibility. Thus, proteins from psychrophilic organisms are excellent models to…”
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The role of the N-terminal tail for the oligomerization, folding and stability of human frataxin by Faraj, Santiago E., Venturutti, Leandro, Roman, Ernesto A., Marino-Buslje, Cristina B., Mignone, Astor, Tosatto, Silvio C.E., Delfino, José M., Santos, Javier

“…The N-terminal stretch of human frataxin (hFXN) intermediate (residues 42–80) is not conserved throughout evolution and, under defined experimental conditions,…”
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