Search Results - "Farahmand, Leila"

Breast cancer: Biology, biomarkers, and treatments by Barzaman, Khadijeh, Karami, Jafar, Zarei, Zeinab, Hosseinzadeh, Aysooda, Kazemi, Mohammad Hossein, Moradi-Kalbolandi, Shima, Safari, Elahe, Farahmand, Leila

“…•BCSCs are the most critical cells leading to chemo and radio-resistance in tumor therapy.•Signaling pathways/metabolic components in BCSC could be targeted as…”
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Triple-negative breast cancer: understanding Wnt signaling in drug resistance by Merikhian, Parnaz, Eisavand, Mohammad Reza, Farahmand, Leila

“…Abstract Triple-negative breast cancer (TNBC) is not as prevalent as hormone receptor or HER2-positive breast cancers and all receptor tests come back…”
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Matrix stiffening and acquired resistance to chemotherapy: concepts and clinical significance by Darvishi, Behrad, Eisavand, Mohammad Reza, Majidzadeh-A, Keivan, Farahmand, Leila

“…Extracellular matrix (ECM) refers to the non-cellular components of the tumour microenvironment, fundamentally providing a supportive scaffold for cellular…”
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Challenges facing antiangiogenesis therapy: The significant role of hypoxia‐inducible factor and MET in development of resistance to anti‐vascular endothelial growth factor‐targeted therapies by Mahdi, Ali, Darvishi, Behrad, Majidzadeh‐A, Keivan, Salehi, Malihe, Farahmand, Leila

“…It is now fully recognized that along with multiple physiological functions, angiogenesis is also involved in the fundamental process and pathobiology of…”
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Crosstalk between MUC1 and VEGF in angiogenesis and metastasis: a review highlighting roles of the MUC1 with an emphasis on metastatic and angiogenic signaling by Khodabakhsh, Farnaz, Merikhian, Parnaz, Eisavand, Mohammad Reza, Farahmand, Leila

“…VEGF and its receptor family (VEGFR) members have unique signaling transduction system that play significant roles in most pathological processes, such as…”
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Anticancer potentiality and mode of action of low-carbohydrate proteins and peptides from mushrooms by Rezvani, Vala, Pourianfar, Hamid R., Mohammadnejad, Safoora, Madjid Ansari, Alireza, Farahmand, Leila

“…Severe side effects of chemotherapy as well as drug resistance highlight the ongoing need to discover novel natural bioactive compounds with anticancer…”
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The Role of Mucosal Immunity and Recombinant Probiotics in SARS-CoV2 Vaccine Development by Moradi-kalbolandi, Shima, Majidzadeh-A, Keyvan, Abdolvahab, Mohadeseh Haji, Jalili, Neda, Farahmand, Leila

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), causing the 2019 novel coronavirus disease (COVID-19), was introduced by WHO (World Health…”
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Stimuli-Responsive Mesoporous Silica NPs as Non-viral Dual siRNA/Chemotherapy Carriers for Triple Negative Breast Cancer by Darvishi, Behrad, Farahmand, Leila, Majidzadeh-A, Keivan

“…Triple negative breast cancer (TNBC) is the most aggressive and lethal subtype of breast cancer. It is associated with a very poor prognosis and intrinsically…”
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The antiproliferative effects of cold atmospheric plasma‐activated media on different cancer cell lines, the implication of ozone as a possible underlying mechanism by Mokhtari, Hesam, Farahmand, Leila, Yaserian, Kiomars, Jalili, Neda, Majidzadeh‐A, Keivan

“…Recent studies have proven several promising anticancer activities for cold atmospheric plasma (CAP) against a wide range of cancer cells in vitro. Recently,…”
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MUC1 is a potential target to overcome trastuzumab resistance in breast cancer therapy by Hosseinzadeh, Aysooda, Merikhian, Parnaz, Naseri, Nazanin, Eisavand, Mohammad Reza, Farahmand, Leila

“…Although resistance is its major obstacle in cancer therapy, trastuzumab is the most successful agent in treating epidermal growth factor receptor 2 positive…”
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Monoclonal antibody‐based therapeutics, targeting the epidermal growth factor receptor family: from herceptin to Pan HER by Moradi‐Kalbolandi, Shima, Hosseinzade, Aysooda, Salehi, Malihe, Merikhian, Parnaz, Farahmand, Leila

“…Objectives Monoclonal antibody‐based of cancer therapy has been considered as one of the most successful therapeutic strategies for both haematologic…”
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NF-κB as the main node of resistance to receptor tyrosine kinase inhibitors in triple-negative breast cancer by Darvishi, Behrad, Farahmand, Leila, Eslami-S, Zahra, Majidzadeh-A, Keivan

“…Graphical abstract Although accounting for merely a minute portion of diagnosed breast cancers, disproportionate number of deaths and associated low survival…”
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Suppression of chronic inflammation with engineered nanomaterials delivering nuclear factor κB transcription factor decoy oligodeoxynucleotides by Farahmand, Leila, Darvishi, Behrad, Majidzadeh-A, Keivan

“…As a prototypical pro-inflammatory transcription factor, constitutive activation of NF-κB signaling pathway has been reported in several chronic inflammatory…”
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Anti-MUC1 nanobody conjugated by chitosan nanoparticle with enhancement of anti-proliferation activity in breast cancer cell lines by Khodabakhsh, Farnaz, Shokri, Shima, Jalili, Neda, Moradi-Kalbolandi, Shima, Dashtestani, Fariba, Farahmand, Leila

“…Breast cancer is one of the most common cancers among women. Antibodies are used to deliver a specific drug to the tumor area. Nanotechnology and monoclonal…”
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Recombinant nanobody against MUC1 tandem repeats inhibits growth, invasion, metastasis, and vascularization of spontaneous mouse mammary tumors by Merikhian, Parnaz, Darvishi, Behrad, Jalili, Neda, Esmailinejad, Mohammad Reza, Khatibi, Azadeh Sharif, Kalbolandi, Shima Moradi, Salehi, Malihe, Mosayebzadeh, Marjan, Barough, Mahdieh Shokrollahi, Majidzadeh‐A, Keivan, Yadegari, Fatemeh, Rahbarizadeh, Fatemeh, Farahmand, Leila

“…Alteration in glycosylation pattern of MUC1 mucin tandem repeats during carcinomas has been shown to negatively affect adhesive properties of malignant cells…”
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Anti-cancer therapeutic strategies based on HGF/MET, EpCAM, and tumor-stromal cross talk by Barzaman, Khadijeh, Vafaei, Rana, Samadi, Mitra, Kazemi, Mohammad Hossein, Hosseinzadeh, Aysooda, Merikhian, Parnaz, Moradi-Kalbolandi, Shima, Eisavand, Mohammad Reza, Dinvari, Houra, Farahmand, Leila

“…Abstract As an intelligent disease, tumors apply several pathways to evade the immune system. It can use alternative routes to bypass intracellular signaling…”
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Synthesized Anti-HER2 Trastuzumab-MCC-DM1 Conjugate: An Evaluation of Efficacy and Cytotoxicity by Shafiee, Soodabeh, Mirzaei, Roya, Salehi, Malihe, Jalili, Neda, Taheri, Amir, Farahmand, Leila

“…Trastuzumab is a humanized monoclonal antibody that targets site-specifically human epidermal growth factor-2 receptor (HER2) cell surface antigen…”
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MED1 may explain the interaction between receptor tyrosine kinases and ERα66 in the complicated network of Tamoxifen resistance by Mansouri, Sepideh, Naghavi-al-Hosseini, Fateme, Farahmand, Leila, Majidzadeh-A, Keivan

“…According to the American Society of Clinical Oncology or ASCO's clinical practice guidelines, administration of Tamoxifen for hormone receptor positive…”
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Metas-Chip precisely identifies presence of micrometastasis in live biopsy samples by label free approach by Nikshoar, Mohammad Saeid, Khayamian, Mohammad Ali, Ansaryan, Saeid, Sanati, Hassan, Gharooni, Milad, Farahmand, Leila, Rezakhanloo, Farshad, Majidzadeh-A, Keivan, Hoseinpour, Parisa, Dadgari, Shahrzad, Kiani-M, Leila, Saqafi, Mohammad, Gity, Masoumeh, Abdolahad, Mohammad

“…Detecting the micrometastasis is a major challenge in patients’ survival. The small volume of the biopsied tissue results in limited number of…”
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Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study by Vafaei, Rana, Samadi, Mitra, Hosseinzadeh, Aysooda, Barzaman, Khadijeh, Esmailinejad, MohammadReza, Khaki, Zohreh, Farahmand, Leila

“…Mucin-1 (MUC-1) is a transmembrane glycoprotein, which bears many similarities between dogs and humans. Since the existence of animal models is essential to…”
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