Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery

In a randomized trial, 5400 patients scheduled to undergo CABG were assigned either to an anesthetic regimen that included a volatile anesthetic or to total intravenous anesthesia. At 1 year, there was no significant difference between the two groups in the number of deaths from any cause.

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 380; no. 13; pp. 1214 - 1225
Main Authors:	Landoni, Giovanni, Lomivorotov, Vladimir V, Nigro Neto, Caetano, Monaco, Fabrizio, Pasyuga, Vadim V, Bradic, Nikola, Lembo, Rosalba, Gazivoda, Gordana, Likhvantsev, Valery V, Lei, Chong, Lozovskiy, Andrey, Di Tomasso, Nora, Bukamal, Nazar A.R, Silva, Fernanda S, Bautin, Andrey E, Ma, Jun, Crivellari, Martina, Farag, Ahmed M.G.A, Uvaliev, Nikolay S, Carollo, Cristiana, Pieri, Marina, Kunstýř, Jan, Wang, Chew Yin, Belletti, Alessandro, Hajjar, Ludhmila A, Grigoryev, Evgeny V, Agrò, Felice E, Riha, Hynek, El-Tahan, Mohamed R, Scandroglio, A. Mara, Elnakera, Abeer M, Baiocchi, Massimo, Navalesi, Paolo, Shmyrev, Vladimir A, Severi, Luca, Hegazy, Mohammed A, Crescenzi, Giuseppe, Ponomarev, Dmitry N, Brazzi, Luca, Arnoni, Renato, Tarasov, Dmitry G, Jovic, Miomir, Calabrò, Maria G, Bove, Tiziana, Bellomo, Rinaldo, Zangrillo, Alberto
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 28-03-2019
Subjects:	Administration, Inhalation Aged Anesthesia Anesthesia, General Anesthesia, Intravenous Anesthetics Anesthetics, General - pharmacology Anesthetics, Intravenous Biomarkers Coronary artery Coronary Artery Bypass Coronary Artery Disease - mortality Coronary Artery Disease - physiopathology Coronary Artery Disease - surgery Data processing Elective Surgical Procedures Female Gene expression Heart attacks Heart surgery Hospitals Humans Intensive care Intravenous administration Ischemia Isoflurane Kaplan-Meier Estimate Male Medical personnel Middle Aged Mortality Myocardial infarction Patients Sevoflurane Single-Blind Method Stroke Volume Beijing China Italy Malaysia China
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Description
Summary:	In a randomized trial, 5400 patients scheduled to undergo CABG were assigned either to an anesthetic regimen that included a volatile anesthetic or to total intravenous anesthesia. At 1 year, there was no significant difference between the two groups in the number of deaths from any cause.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-News-3 ObjectType-Feature-4 content type line 23 ObjectType-Undefined-2
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1816476