Complete regression of myocardial involvement associated with lymphoma following chemotherapy
Cardiac involvement as an initial presentation of malignant lymphoma is a rare occurrence.We describe the case of a 26 year old man who had initially been diagnosed with myocardial infiltration on an echocardiogram,presenting with a testicular mass and unilateral peripheral facial paralysis.On admis...
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| Published in: | World journal of cardiology Vol. 5; no. 9; pp. 364 - 368 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Baishideng Publishing Group Co., Limited
26-09-2013
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Cardiac involvement as an initial presentation of malignant lymphoma is a rare occurrence.We describe the case of a 26 year old man who had initially been diagnosed with myocardial infiltration on an echocardiogram,presenting with a testicular mass and unilateral peripheral facial paralysis.On admission,electrocardiograms(ECG)revealed negative T-waves in all leads and ST-segment elevation in the inferior leads.On twodimensional echocardiography,there was infiltration of the pericardium with mild effusion,infiltrative thickening of the aortic walls,both atria and the interatrial septum and a mildly depressed systolic function of both ventricles.An axillary biopsy was performed and reported as a T-cell lymphoblastic lymphoma(T-LBL).Following the diagnosis and staging,chemotherapy was started.Twenty-two days after finishing the first cycle of chemotherapy,the ECG showed regression of T-wave changes in all leads and normalization of the ST-segment elevation in the inferior leads.A followup two-dimensional echo confirmed regression of the myocardial infiltration.This case report illustrates a lymphoma presenting with testicular mass,unilateral peripheral facial paralysis and myocardial involvement,and demonstrates that regression of infiltration can be achieved by intensive chemotherapy treatment.To our knowledge,there are no reported cases of T-LBL presenting as a testicular mass and unilateral peripheral facial paralysis,with complete regression of myocardial involvement. |
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| Bibliography: | Juan Pablo Vinicki;Tomás F Cianciulli;Gustavo A Farace;María C Saccheri;Jorge A Lax;Lucía R Kazelián;Adolfo Wachs;Department of Internal Medicine,Hospital of the Government of the City of Buenos Aires "Dr.Cosme Argerich";Department of Cardiology,Hospital of the Government of the City of Buenos Aires "Dr.Cosme Argerich" ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Correspondence to: Tomás F Cianciulli, Professor, MD, FACC, Department of Cardiology, Hospital of the Government of the City of Buenos Aires “Dr. Cosme Argerich”, Pi y Margall 750, Capital Federal, Buenos Aires, C1155AHD, Argentina. tcianciulli@gmail.com Author contributions: Wachs A, Vinicki JP and Farace GA attended the patient; Saccheri MC and Kazelián LR prepared the manuscript and figures; Lax JA and Cianciulli TF performed the echocardiographic images and participated in the design and review of the manuscript; all authors read and approved the final manuscript. Telephone: +54-11-41210879 Fax: +54-11-48015510 |
| ISSN: | 1949-8462 1949-8462 |
| DOI: | 10.4330/wjc.v5.i9.364 |