Search Results - "Fantini, Damiano"

MutSignatures: an R package for extraction and analysis of cancer mutational signatures by Fantini, Damiano, Vidimar, Vania, Yu, Yanni, Condello, Salvatore, Meeks, Joshua J.

“…Cancer cells accumulate somatic mutations as result of DNA damage, inaccurate repair and other mechanisms. Different genetic instability processes result in…”
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Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment by Tell, Gianluca, Fantini, Damiano, Quadrifoglio, Franco

“…The apurinic endonuclease 1/redox factor-1 (APE1) has a crucial function in DNA repair and in redox signaling in mammals, and recent studies identify it as an…”
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Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy by Wang, Lu, Zhao, Zibo, Ozark, Patrick A., Fantini, Damiano, Marshall, Stacy A., Rendleman, Emily J., Cozzolino, Kira A., Louis, Nundia, He, Xingyao, Morgan, Marc A., Takahashi, Yoh-hei, Collings, Clayton K., Smith, Edwin R., Ntziachristos, Panagiotis, Savas, Jeffrey N., Zou, Lihua, Hashizume, Rintaro, Meeks, Joshua J., Shilatifard, Ali

“…The lysine methyltransferase KMT2C (also known as MLL3), a subunit of the COMPASS complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene…”
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Identification of Differential Tumor Subtypes of T1 Bladder Cancer by Robertson, A. Gordon, Groeneveld, Clarice S., Jordan, Brian, Lin, Xiquo, McLaughlin, Kimberly A., Das, Arighno, Fall, Leigh Ann, Fantini, Damiano, Taxter, Timothy J., Mogil, Lauren S., Lindskrog, Sia Viborg, Dyrskjøt, Lars, McConkey, David J., Svatek, Robert S., de Reyniès, Aurélien, Castro, Mauro A.A., Meeks, Joshua J.

“…Stage T1 bladder cancers have the highest progression and recurrence rates of all non–muscle-invasive bladder cancers (NMIBCs). Most T1 cancers are treated…”
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DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer by Huang, Shuo, Fantini, Damiano, Merrill, Bradley J, Bagchi, Srilata, Guzman, Grace, Raychaudhuri, Pradip

“…Deregulation of the Wnt/β-catenin signaling pathway drives the development of colorectal cancer, but understanding of this pathway remains incomplete. Here, we…”
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APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process by Vascotto, Carlo, Fantini, Damiano, Romanello, Milena, Cesaratto, Laura, Deganuto, Marta, Leonardi, Antonio, Radicella, J. Pablo, Kelley, Mark R., D'Ambrosio, Chiara, Scaloni, Andrea, Quadrifoglio, Franco, Tell, Gianluca

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression by Ghannoum, Salim, Fantini, Damiano, Zahoor, Muhammad, Reiterer, Veronika, Phuyal, Santosh, Leoncio Netto, Waldir, Sørensen, Øystein, Iyer, Arvind, Sengupta, Debarka, Prasmickaite, Lina, Mælandsmo, Gunhild Mari, Köhn-Luque, Alvaro, Farhan, Hesso

“…Our understanding of how speed and persistence of cell migration affects the growth rate and size of tumors remains incomplete. To address this, we developed a…”
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Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions by Fantini, Damiano, Vascotto, Carlo, Marasco, Daniela, D'Ambrosio, Chiara, Romanello, Milena, Vitagliano, Luigi, Pedone, Carlo, Poletto, Mattia, Cesaratto, Laura, Quadrifoglio, Franco, Scaloni, Andrea, Radicella, J. Pablo, Tell, Gianluca

“…Apurinic/apyrimidinic endonuclease 1 (APE1), an essential protein in mammals, is involved in base excision DNA repair (BER) and in regulation of gene…”
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Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma by Podojil, Joseph R., Glaser, Alexander P., Baker, Dylan, Courtois, Elise T., Fantini, Damiano, Yu, Yanni, Eaton, Valerie, Sivajothi, Santhosh, Chiang, Mingyi, Das, Arighno, McLaughlin, Kimberly A., Robson, Paul, Miller, Stephen D., Meeks, Joshua J.

“…Patients with locally advanced and metastatic urothelial carcinoma have a low survival rate (median 15.7 months, 13.1-17.8), with only a 23% response rate to…”
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The prion protein is critical for DNA repair and cell survival after genotoxic stress by Bravard, Anne, Auvré, Frédéric, Fantini, Damiano, Bernardino-Sgherri, Jacqueline, Sissoëff, Ludmilla, Daynac, Mathieu, Xu, Zhou, Etienne, Olivier, Dehen, Capucine, Comoy, Emmanuel, Boussin, François D, Tell, Gianluca, Deslys, Jean-Philippe, Radicella, J Pablo

“…The prion protein (PrP) is highly conserved and ubiquitously expressed, suggesting that it plays an important physiological function. However, despite decades…”
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Baricitinib-associated changes in global gene expression during a 24-week phase II clinical systemic lupus erythematosus trial implicates a mechanism of action through multiple immune-related pathways by Dörner, Thomas, Tanaka, Yoshiya, Petri, Michelle A, Smolen, Josef S, Wallace, Daniel J, Dow, Ernst R, Higgs, Richard E, Rocha, Guilherme, Crowe, Brenda, Benschop, Robert J, Byers, Nicole L, Silk, Maria E, de Bono, Stephanie, Fantini, Damiano, Hoffman, Robert W

“…ObjectiveTo characterise the molecular pathways impacted by the pharmacologic effects of the Janus kinase (JAK) 1 and JAK2 inhibitor baricitinib in…”
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DIscBIO: A User-Friendly Pipeline for Biomarker Discovery in Single-Cell Transcriptomics by Ghannoum, Salim, Leoncio Netto, Waldir, Fantini, Damiano, Ragan-Kelley, Benjamin, Parizadeh, Amirabbas, Jonasson, Emma, Ståhlberg, Anders, Farhan, Hesso, Köhn-Luque, Alvaro

“…The growing attention toward the benefits of single-cell RNA sequencing (scRNA-seq) is leading to a myriad of computational packages for the analysis of…”
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1056 XTX301, a tumor activated, half-life extended IL-12 promoted potent anti-tumor immunity and activity across multiple syngeneic tumor models by Malkova, Natalia V, Patel, Ekta, Vu, Sallyann, Fantini, Damiano, Fanny, Manoussa, Guzman, Wilson, Hsiao, Stephanie, Johnson, Parker, Yerov, Oleg, Jenkins, Kurt, Madala, Hanumantha Rao, O’Toole, Caitlin, Taylor, Jake, Pederzoli-Ribeil, Magali, Eryilmaz, Ertan, Nicholson, Benjamin, Bialucha, Uli, O’Neil, Jennifer

“…BackgroundInterleukin-12 (IL-12) is a proinflammatory cytokine that bridges innate and adaptive immunity by stimulating the differentiation of T helper 1 cells…”
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611 XTX202–01/02–001, Phase 1/2 first-in human study of XTX202, a masked, tumor-activated IL-2βγ, in patients with advanced solid tumors: results from phase 1 by Hanna, Diana, Zakharia, Yousef, Goel, Sanjay, Hurley, Randy, Pelster, Meredith, El-Khoueiry, Anthony, Thomas, Jacob, Powderly, John, Miller, David, Wu, Richard, Chmielowski, Bartosz, Rapisuwon, Suthee, Gupta, Anurag, Duncan, Meghan, Siu, Aika, Patel, Ekta, Fantini, Damiano, Crowe, David, Paramasivan, Sattanathan, Lee, George, Luptakova, Katarina, McKean, Meredith

“…BackgroundAldesleukin requires high systemic doses (8.4 million IU/kg equaling 0.518 mg/kg per weekly cycle) to achieve therapeutic benefit; however, such…”
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Analysis of Mutational Signatures Using the mutSignatures R Library by Fantini, Damiano, Meeks, Joshua J

“…Accumulation of somatic mutations is a hallmark of cancer. Defects in DNA metabolism and DNA repair and exposure to mutagens may result in characteristic…”
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Molecular footprints of muscle-invasive bladder cancer in smoking and nonsmoking patients by Fantini, Damiano, Seiler, Roland, Meeks, Joshua J.

“…•GPR15 gene was up-regulated in bladder tumors from smokers.•Mutation burden is similar in bladder tumors from nonsmokers and current smokers.•Tobacco-derived…”
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Genomic classification and risk stratification of bladder cancer by Fantini, Damiano, Meeks, Joshua J.

“…Bladder cancer is the fourth most common cancer in men and fifth most common overall. The use of next-generation sequencing (NGS) approaches is crucial to…”
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The evolving genomic landscape of urothelial carcinoma by Glaser, Alexander P., Fantini, Damiano, Shilatifard, Ali, Schaeffer, Edward M., Meeks, Joshua J.

“…Key Points Urothelial carcinoma has a high degree of mutational heterogeneity and a high frequency of somatic mutations compared with other solid tumours The…”
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A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer by Fantini, Damiano, Glaser, Alexander P., Rimar, Kalen J., Wang, Yiduo, Schipma, Matthew, Varghese, Nobish, Rademaker, Alfred, Behdad, Amir, Yellapa, Aparna, Yu, Yanni, Sze, Christie Ching-Lin, Wang, Lu, Zhao, Zibo, Crawford, Susan E., Hu, Deqing, Licht, Jonathan D., Collings, Clayton K., Bartom, Elizabeth, Theodorescu, Dan, Shilatifard, Ali, Meeks, Joshua J.

“…The N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) mouse model is an attractive model system of muscle-invasive bladder cancer (MIBC) as it recapitulates the…”
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APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response by Glaser, Alexander P, Fantini, Damiano, Wang, Yiduo, Yu, Yanni, Rimar, Kalen J, Podojil, Joseph R, Miller, Stephen D, Meeks, Joshua J

“…APOBEC enzymes are responsible for a mutation signature (TCW>T/G) implicated in a wide variety of tumors. We explore the APOBEC mutational signature in bladder…”
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