Search Results - "Fanous, Joseph"

Enhancing Oral Bioavailability of Cyclic RGD Hexa-peptides by the Lipophilic Prodrug Charge Masking Approach: Redirection of Peptide Intestinal Permeability from a Paracellular to Transcellular Pathway by Schumacher-Klinger, Adi, Fanous, Joseph, Merzbach, Shira, Weinmüller, Michael, Reichart, Florian, Räder, Andreas F. B, Gitlin-Domagalska, Agata, Gilon, Chaim, Kessler, Horst, Hoffman, Amnon

“…Hydrophilic peptides constitute most of the active peptides. They mostly permeate via tight junctions (paracellular pathway) in the intestine. This…”
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Zebrafish Larvae as an in vivo Model for Antimicrobial Activity Tests against Intracellular Salmonella by Hauswirth, Patrick, Buck, Jonas, Puligilla, Ramya, Alter, Claudio Luca, Sieber, Sandro, Claudi, Beatrice, Fanous, Joseph, Bumann, Dirk, Huwyler, Jörg

“…Blood infections from multi-drug-resistant pose a major health burden. This is especially true because can survive and replicate intracellularly, and the…”
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Antibiotic chemotherapy against heterogeneous pathogen populations in complex host tissues [version 1; peer review: 2 approved] by Bumann, Dirk, Fanous, Joseph, Li, Jiagui, Goormaghtigh, Frédéric

“…Antibiotic chemotherapy effectively cures many infections caused by susceptible bacterial pathogens. However, in some cases, even extended treatment duration…”
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Outer membrane permeability: Antimicrobials and diverse nutrients bypass porins in Pseudomonas aeruginosa by Ude, Johanna, Tripathi, Vishwachi, Buyck, Julien M., Söderholm, Sandra, Cunrath, Olivier, Fanous, Joseph, Claudi, Beatrice, Egli, Adrian, Schleberger, Christian, Hiller, Sebastian, Bumann, Dirk

“…Gram-negative bacterial pathogens have an outer membrane that restricts entry of molecules into the cell. Water-filled protein channels in the outer membrane,…”
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Tissue compartmentalization enables Salmonella persistence during chemotherapy by Li, Jiagui, Claudi, Beatrice, Fanous, Joseph, Chicherova, Natalia, Cianfanelli, Francesca Romana, Campbell, Robert A. A., Bumann, Dirk

“…Antimicrobial chemotherapy can fail to eradicate the pathogen, even in the absence of antimicrobial resistance. Persisting pathogens can subsequently cause…”
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Development of a Novel Backbone Cyclic Peptide Inhibitor of the Innate Immune TLR/IL1R Signaling Protein MyD88 by Dishon, Shira, Schumacher, Adi, Fanous, Joseph, Talhami, Alaa, Kassis, Ibrahim, Karussis, Dimitrios, Gilon, Chaim, Hoffman, Amnon, Nussbaum, Gabriel

“…MyD88 is a cytoplasmic adaptor protein that plays a central role in signaling downstream of the TLRs and the IL1R superfamily. We previously demonstrated that…”
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Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3 by Weinmüller, Michael, Rechenmacher, Florian, Kiran Marelli, Udaya, Reichart, Florian, Kapp, Tobias G., Räder, Andreas F. B., Di Leva, Francesco Saverio, Marinelli, Luciana, Novellino, Ettore, Muñoz‐Félix, José M., Hodivala‐Dilke, Kairbaan, Schumacher, Adi, Fanous, Joseph, Gilon, Chaim, Hoffman, Amnon, Kessler, Horst

“…A highly systematic approach for the development of both orally bioavailable and bioactive cyclic N‐methylated hexapeptides as high affinity ligands for the…”
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Superiority of the S,S conformation in diverse pharmacological processes: Intestinal transport and entry inhibition activity of novel anti-HIV drug lead by Fanous, Joseph, Swed, Avi, Joubran, Salim, Hurevich, Mattan, Britan-Rosich, Elena, Kotler, Moshe, Gilon, Chaim, Hoffman, Amnon

“…[Display omitted] Chirality is an important aspect in many pharmacological processes including drug transport and metabolism. The current investigation…”
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Quantitative contribution of efflux to multi-drug resistance of clinical Escherichia coli and Pseudomonas aeruginosa strains by Cunrath, Olivier, Meinel, Dominik M., Maturana, Pauline, Fanous, Joseph, Buyck, Julien M., Saint Auguste, Pamela, Seth-Smith, Helena M.B., Körner, Jonas, Dehio, Christoph, Trebosc, Vincent, Kemmer, Christian, Neher, Richard, Egli, Adrian, Bumann, Dirk

“…Efflux pumps mediate antimicrobial resistance in several WHO critical priority bacterial pathogens. However, most available data come from laboratory strains…”
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Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin[alpha]v[beta]3 by Weinmuller, Michael, Rechenmacher, Florian, KiranMarelli, Udaya, Reichart, Florian, Kapp, Tobias G, Rader, Andreas F B, DiLeva, Francesco Saverio, Marinelli, Luciana, Novellino, Ettore, Munoz-Felix, José M, Hodivala-Dilke, Kairbaan, Schumacher, Adi, Fanous, Joseph, Gilon, Chaim, Hoffman, Amnon, Kessler, Horst

“…A highly systematic approach for the development of both orally bioavailable and bioactive cyclic N-methylated hexapeptides as high affinity ligands for the…”
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The role of molecular physicochemical properties and apolipoproteins in association of drugs with triglyceride-rich lipoproteins: in-silico prediction of uptake by chylomicrons by Gershkovich, Pavel, Fanous, Joseph, Qadri, Bashir, Yacovan, Avihai, Amselem, Shimon, Hoffman, Amnon

“…Objectives The uptake of drugs by chylomicrons is a key element in both intestinal lymphatic transport and postprandial alterations in the disposition profile…”
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The role of molecular physicochemical properties and apolipoproteins in association of drugs with triglyceride-rich lipoproteins: in-silico prediction of uptake by chylomicrons by Gershkovich, Pavel, Fanous, Joseph, Qadri, Bashir, Yacovan, Avihai, Amselem, Shimon, Hoffman, Amnon

“…OBJECTIVESThe uptake of drugs by chylomicrons is a key element in both intestinal lymphatic transport and postprandial alterations in the disposition profile…”
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Corrigendum to “Inhibition of inositol monophosphatase (IMPase) at the calbindin-D28k binding site: Molecular and behavioural aspects” [Eur. Neuropsychopharmacol. 23 (2013) 1806–1815] by Levi, Itzhak, Eskira, Yael, Eisenstein, Miriam, Gilon, Chaim, Hoffman, Amnon, Tal-Gan, Yftah, Fanous, Joseph, Bersudsky, Yuly, Belmaker, RH, Agam, Galila, Almog, Orna

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Tailoring of Integrin Ligands: Probing the Charge Capability of the Metal Ion-Dependent Adhesion Site by Bollinger, Markus, Manzenrieder, Florian, Kolb, Roman, Bochen, Alexander, Neubauer, Stefanie, Marinelli, Luciana, Limongelli, Vittorio, Novellino, Ettore, Moessmer, Georg, Pell, Reinhard, Lindner, Wolfgang, Fanous, Joseph, Hoffman, Amnon, Kessler, Horst

“…Intervention in integrin-mediated cell adhesion and integrin signaling pathways is an ongoing area of research in medicinal chemistry and drug development. One…”
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Quantitative contribution of efflux to multi-drug resistance of clinical Escherichia coli and Pseudomonas aeruginosa strainsResearch in context by Olivier Cunrath, Dominik M. Meinel, Pauline Maturana, Joseph Fanous, Julien M. Buyck, Pamela Saint Auguste, Helena M.B. Seth-Smith, Jonas Körner, Christoph Dehio, Vincent Trebosc, Christian Kemmer, Richard Neher, Adrian Egli, Dirk Bumann

“…Background: Efflux pumps mediate antimicrobial resistance in several WHO critical priority bacterial pathogens. However, most available data come from…”
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Inhibition of inositol monophosphatase (IMPase) at the calbindin-D28k binding site: Molecular and behavioral aspects by Levi, Itzhak, Eskira, Yael, Eisenstein, Miriam, Gilon, Chaim, Hoffman, Amnon, Talgan, Yiftach, Fanous, Joseph, Bersudsky, Yuly, Belmaker, RH, Agam, Galila, Almog, Orna

“…Abstract Bipolar-disorder (manic-depressive illness) is a severe chronic illness affecting ∼1% of the adult population. It is treated with mood-stabilizers,…”
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Lösung des Problems mangelnder oraler Verfügbarkeit cyclischer Hexapeptide: Entwicklung eines selektiven, oral verfügbaren Liganden für das Integrin αvβ3 by Weinmüller, Michael, Rechenmacher, Florian, Kiran Marelli, Udaya, Reichart, Florian, Kapp, Tobias G., Räder, Andreas F. B., Di Leva, Francesco Saverio, Marinelli, Luciana, Novellino, Ettore, Muñoz‐Félix, José M., Hodivala‐Dilke, Kairbaan, Schumacher, Adi, Fanous, Joseph, Gilon, Chaim, Hoffman, Amnon, Kessler, Horst

“…Ein systematischer Ansatz für die Entwicklung oral verfügbarer wie auch biologisch aktiver, cyclischer, N‐methylierter Hexapeptide als hoch affine Liganden für…”
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Lösung des Problems mangelnder oraler Verfugbarkeit cyclischer Hexapeptide: Entwicklung eines selektiven, oral verfugbaren Liganden fur das Integrin[alpha]v[beta]3 by Weinmuller, Michael, Rechenmacher, Florian, KiranMarelli, Udaya, Reichart, Florian, Kapp, Tobias G, Rader, Andreas F B, DiLeva, Francesco Saverio, Marinelli, Luciana, Novellino, Ettore, Munoz-Felix, José M, Hodivala-Dilke, Kairbaan, Schumacher, Adi, Fanous, Joseph, Gilon, Chaim, Hoffman, Amnon, Kessler, Horst

“…Ein systematischer Ansatz fur die Entwicklung oral verfugbarer wie auch biologisch aktiver, cyclischer, N-methylierter Hexapeptide als hoch affine Liganden fur…”
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