Search Results - "Fanning, Ellen"

SV40 DNA replication: From the A gene to a nanomachine by Fanning, Ellen, Zhao, Kun

“…Abstract Duplication of the simian virus 40 (SV40) genome is the best understood eukaryotic DNA replication process to date. Like most prokaryotic genomes, the…”
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A Distinct DNA-Methylation Boundary in the 5′- Upstream Sequence of the FMR1 Promoter Binds Nuclear Proteins and Is Lost in Fragile X Syndrome by Naumann, Anja, Hochstein, Norbert, Weber, Stefanie, Fanning, Ellen, Doerfler, Walter

“…We have discovered a distinct DNA-methylation boundary at a site between 650 and 800 nucleotides upstream of the CGG repeat in the first exon of the human FMR1…”
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ATM and ATR activities maintain replication fork integrity during SV40 chromatin replication by Sowd, Gregory A, Li, Nancy Yan, Fanning, Ellen

“…Mutation of DNA damage checkpoint signaling kinases ataxia telangiectasia-mutated (ATM) or ATM- and Rad3-related (ATR) results in genomic instability…”
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A wolf in sheep's clothing: SV40 co-opts host genome maintenance proteins to replicate viral DNA by Sowd, Gregory A, Fanning, Ellen

“…Intriguingly, bacterially expressed Tag double hexamer displays only the parallel conformation, consistent with its inability to activate bidirectional origin…”
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Human DNA helicase B functions in cellular homologous recombination and stimulates Rad51-mediated 5'-3' heteroduplex extension in vitro by Liu, Hanjian, Yan, Peijun, Fanning, Ellen

“…Homologous recombination is involved in the repair of DNA damage and collapsed replication fork, and is critical for the maintenance of genomic stability. Its…”
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RPA2 Is a Direct Downstream Target for ATR to Regulate the S-phase Checkpoint by Olson, Erin, Nievera, Christian J., Klimovich, Vitaly, Fanning, Ellen, Wu, Xiaohua

“…Upon DNA damage, replication is inhibited by the S-phase checkpoint. ATR (ataxia telangiectasia mutated- and Rad3-related) is specifically involved in the…”
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SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products by Sowd, Gregory A, Mody, Dviti, Eggold, Joshua, Cortez, David, Friedman, Katherine L, Fanning, Ellen

“…Simian virus 40 (SV40) and cellular DNA replication rely on host ATM and ATR DNA damage signaling kinases to facilitate DNA repair and elicit cell cycle arrest…”
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Human DNA Helicase B (HDHB) Binds to Replication Protein A and Facilitates Cellular Recovery from Replication Stress by Guler, Gulfem Dilek, Liu, Hanjian, Vaithiyalingam, Sivaraja, Arnett, Diana R., Kremmer, Elisabeth, Chazin, Walter J., Fanning, Ellen

“…Maintenance of genomic stability in proliferating cells depends on a network of proteins that coordinate chromosomal replication with DNA damage responses…”
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An Iron-Sulfur Cluster in the C-terminal Domain of the p58 Subunit of Human DNA Primase by Weiner, Brian E., Huang, Hao, Dattilo, Brian M., Nilges, Mark J., Fanning, Ellen, Chazin, Walter J.

“…DNA primase synthesizes short RNA primers that are required to initiate DNA synthesis on the parental template strands during DNA replication. Eukaryotic…”
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Ataxia Telangiectasia-Mutated Damage-Signaling Kinase- and Proteasome-Dependent Destruction of Mre11-Rad50-Nbs1 Subunits in Simian Virus 40-Infected Primate Cells by Zhao, Xiaorong, Madden-Fuentes, Ramiro J, Lou, Becky X, Pipas, James M, Gerhardt, Jeannine, Rigell, Christopher J, Fanning, Ellen

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Biochemical and Structural Domain Analysis of Xeroderma Pigmentosum Complementation Group C Protein by Bunick, Christopher G, Miller, Michael R, Fuller, Brian E, Fanning, Ellen, Chazin, Walter J

“…XPC is a 940-residue multidomain protein critical for the sensing of aberrant DNA and initiation of global genome nucleotide excision repair. The C-terminal…”
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Simian virus Large T antigen interacts with the N-terminal domain of the 70 kD subunit of Replication Protein A in the same mode as multiple DNA damage response factors by Ning, Boting, Feldkamp, Michael D, Cortez, David, Chazin, Walter J, Friedman, Katherine L, Fanning, Ellen

“…Simian virus 40 (SV40) serves as an important model organism for studying eukaryotic DNA replication. Its helicase, Large T-antigen (Tag), is a…”
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Structural mechanism of RPA loading on DNA during activation of a simple pre-replication complex by Jiang, Xiaohua, Klimovich, Vitaly, Arunkumar, Alphonse I, Hysinger, Erik B, Wang, Yingda, Ott, Robert D, Guler, Gulfem D, Weiner, Brian, Chazin, Walter J, Fanning, Ellen

“…We report that during activation of the simian virus 40 (SV40) pre‐replication complex, SV40 T antigen (Tag) helicase actively loads replication protein A…”
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Defined Sequence Modules and an Architectural Element Cooperate To Promote Initiation at an Ectopic Mammalian Chromosomal Replication Origin by Altman, Amy L., Fanning, Ellen

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An Origin of DNA Replication in the Promoter Region of the Human Fragile X Mental Retardation (FMR1) Gene by Gray, Steven J., Gerhardt, Jeannine, Doerfler, Walter, Small, Lawrence E., Fanning, Ellen

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Domain Architecture and Biochemical Characterization of Vertebrate Mcm10 by Robertson, Patrick D., Warren, Eric M., Zhang, Haijiang, Friedman, David B., Lary, Jeffrey W., Cole, James L., Tutter, Antonin V., Walter, Johannes C., Fanning, Ellen, Eichman, Brandt F.

“…Mcm10 plays a key role in initiation and elongation of eukaryotic chromosomal DNA replication. As a first step to better understand the structure and function…”
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The Human Rad9-Rad1-Hus1 Checkpoint Complex Stimulates Flap Endonuclease 1 by Wang, Wensheng, Brandt, Patrick, Rossi, Marie L., Lindsey-Boltz, Laura, Podust, Vladimir, Fanning, Ellen, Sancar, Aziz, Bambara, Robert A., Lehman, I. Robert

“…The toroidal damage checkpoint complex Rad9-Rad1-Hus1 (9-1-1) has been characterized as a sensor of DNA damage. Flap endonuclease 1 (FEN1) is a…”
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Activation of the DNA Replication Checkpoint through RNA Synthesis by Primase by Michael, W. Matthew, Ott, Robert, Fanning, Ellen, Newport, John

“…When DNA replication is inhibited during the synthesis (S) phase of the cell cycle, a signaling pathway (checkpoint) is activated that serves to prevent…”
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The Chinese Hamster Dihydrofolate Reductase Replication Origin Beta Is Active at Multiple Ectopic Chromosomal Locations and Requires Specific DNA Sequence Elements for Activity by Altman, Amy L., Fanning, Ellen

“…AUTHOR'S CORRECTION ( vol. 22 , p. 6319 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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Insights into the Oligomeric States, Conformational Changes, and Helicase Activities of SV40 Large Tumor Antigen by Gai, Dahai, Li, Dawei, Finkielstein, Carla V., Ott, Robert D., Taneja, Poonam, Fanning, Ellen, Chen, Xiaojiang S.

“…The large T (LT) antigen encoded by SV40 virus is a multi-domain, multi-functional protein that can not only transform cells but can also function as an…”
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