Search Results - "Fann, John"

Improvement of mammalian cell culture performance through surfactant enabled concentrated feed media by Hossler, Patrick, McDermott, Sean, Racicot, Christopher, Fann, John C. H.

“…The design of basal and feed media in mammalian cell culture is paramount towards ensuring acceptable upstream process performance in various operation modes,…”
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Application of pressurized liquid extraction followed by gas chromatography–mass spectrometry to determine 4-nonylphenols in sediments by Ding, Wang-Hsien, Fann, John C.H

“…A time- and solvent-saving method, pressurized liquid extraction (PLE), to extract 4-nonylphenol (4-NP) in sediment was developed. The effects of various…”
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Determination of linear alkylbenzenesulfonates in sediments using pressurized liquid extraction and ion-pair derivatization gas chromatography-mass spectrometry by Ding, Wang-Hsien, Fann, John C.H

“…A time and solvent saving method, called pressurized liquid extraction (PLE), was developed to extract linear alkylbenzenesulfonate (LAS) residues from…”
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Impact of depth filtration on disulfide bond reduction during downstream processing of monoclonal antibodies from CHO cell cultures by O’Mara, Brian, Gao, Zhong‐Hua, Kuruganti, Manju, Mallett, Robert, Nayar, Gautam, Smith, Laura, Meyer, Jeffrey D., Therriault, Jon, Miller, Cameron, Cisney, John, Fann, John

“…Monoclonal antibody interchain disulfide bond reduction was observed in a Chinese Hamster Ovary manufacturing process that used single‐use technologies. A…”
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Identifying low-level sequence variants via next generation sequencing to aid stable CHO cell line screening by Zhang, Sheng, Bartkowiak, Lisa, Nabiswa, Bernard, Mishra, Pratibha, Fann, John, Ouellette, David, Correia, Ivan, Regier, Dean, Liu, Junjian

“…Developing stable Chinese hamster ovary (CHO) cell lines for biotherapeutics is an irreversible process and therefore, key quality attributes, such as sequence…”
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Cell culture media supplementation of uncommonly used sugars sucrose and tagatose for the targeted shifting of protein glycosylation profiles of recombinant protein therapeutics by Hossler, Patrick, McDermott, Sean, Racicot, Christopher, Chumsae, Christopher, Raharimampionona, Haly, Zhou, Yu, Ouellette, David, Matuck, Joseph, Correia, Ivan, Fann, John, Li, Jianmin

“…Protein glycosylation is an important post‐translational modification toward the structure and function of recombinant therapeutics. The addition of…”
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Abstract 1862: ZW191 - a FRα-targeting antibody drug conjugate with strong preclinical activity across multiple FRα-expressing indications by Lawn, Sam, Rojas, Andrea Hernandez, Colombo, Raffaele, Wong, Jodi, Wu, Kaylee, Fung, Vincent, Lasalle, Manuel, Petersen, Mark E., Degefie, Lemlem, Sagoe-Wagner, Araba, Urosev, Dunja, Yang, Luying, Wu, Ambroise, Kim, Catrina, Chua, Amos, Stahl, Kurt, Winters, Geoffrey C., Fann, John C., Rich, Jamie, Barnscher, Stuart

“…Abstract Background: Folate Receptor alpha (FRα) is a validated cancer target that is prevalently expressed in multiple cancers with high unmet need, including…”
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