Search Results - "Fanger, Christopher"

Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice by Just, Stefan, Chenard, Bertrand L, Ceci, Angelo, Strassmaier, Timothy, Chong, Jayhong A, Blair, Nathaniel T, Gallaschun, Randall J, Del Camino, Donato, Cantin, Susan, D'Amours, Marc, Eickmeier, Christian, Fanger, Christopher M, Hecker, Carsten, Hessler, David P, Hengerer, Bastian, Kroker, Katja S, Malekiani, Sam, Mihalek, Robert, McLaughlin, Joseph, Rast, Georg, Witek, JoAnn, Sauer, Achim, Pryce, Christopher R, Moran, Magdalene M

“…Forty million adults in the US suffer from anxiety disorders, making these the most common forms of mental illness. Transient receptor potential channel…”
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TRPA1 mediates formalin-induced pain by McNamara, Colleen R, Mandel-Brehm, Josh, Bautista, Diana M, Siemens, Jan, Deranian, Kari L, Zhao, Michael, Hayward, Neil J, Chong, Jayhong A, Julius, David, Moran, Magdalene M, Fanger, Christopher M

“…The formalin model is widely used for evaluating the effects of analgesic compounds in laboratory animals. Injection of formalin into the hind paw induces a…”
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Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis by Everaerts, Wouter, Zhen, Xiaoguang, Ghosh, Debapriya, Vriens, Joris, Gevaert, Thomas, Gilbert, James P., Hayward, Neil J., McNamara, Colleen R., Xue, Fenqin, Moran, Magdalene M., Strassmaier, Timothy, Uykal, Eda, Owsianik, Grzegorz, Vennekens, Rudi, De Ridder, Dirk, Nilius, Bernd, Fanger, Christopher M., Voets, Thomas, Aldrich, Richard W.

“…Reduced functional bladder capacity and concomitant increased micturition frequency (pollakisuria) are common lower urinary tract symptoms associated with…”
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MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit by Volkmann, Robert A, Fanger, Christopher M, Anderson, David R, Sirivolu, Venkata Ramana, Paschetto, Kathy, Gordon, Earl, Virginio, Caterina, Gleyzes, Melanie, Buisson, Bruno, Steidl, Esther, Mierau, Susanna B, Fagiolini, Michela, Menniti, Frank S

“…GluN2A is the most abundant of the GluN2 NMDA receptor subunits in the mammalian CNS. Physiological and genetic evidence implicate GluN2A-containing receptors…”
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TRPA1 contributes to cold hypersensitivity by del Camino, Donato, Murphy, Sarah, Heiry, Melissa, Barrett, Lee B, Earley, Taryn J, Cook, Colby A, Petrus, Matt J, Zhao, Michael, D'Amours, Marc, Deering, Nate, Brenner, Gary J, Costigan, Michael, Hayward, Neil J, Chong, Jayhong A, Fanger, Christopher M, Woolf, Clifford J, Patapoutian, Ardem, Moran, Magdalene M

“…TRPA1 is a nonselective cation channel expressed by nociceptors. Although it is widely accepted that TRPA1 serves as a broad irritancy receptor for a variety…”
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PTC-174, a positive allosteric modulator of NMDA receptors containing GluN2C or GluN2D subunits by Yi, Feng, Rouzbeh, Nirvan, Hansen, Kasper B., Xu, Yuelian, Fanger, Christopher M., Gordon, Earl, Paschetto, Kathy, Menniti, Frank S., Volkmann, Robert A.

“…NMDA receptors are ionotropic glutamate receptors that mediate excitatory neurotransmission. The diverse functions of these receptors are tuned by deploying…”
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Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice by Leissring, Malcolm A., Akbari, Yama, Fanger, Christopher M., Cahalan, Michael D., Mattson, Mark P., LaFerla, Frank M.

“…Dysregulation of calcium signaling has been causally implicated in brain aging and Alzheimer's disease. Mutations in the presenilin genes (PS1, PS2), the…”
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Impact of Material Shade and Distance from Light Curing Unit Tip on the Depth of Polymerization of Composites by Faria-e-Silva, André L., Fanger, Christopher, Nguyen, Lillian, Howerton, Demetri, Pfeifer, Carmem S.

“…Abstract This study aimed to evaluate the effect of the composite shade and distance from the light-curing unit (LCU) tip on the irradiance reaching the bottom…”
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Mitochondrial Regulation of Store-Operated Calcium Signaling in T Lymphocytes by Hoth, Markus, Fanger, Christopher M., Lewis, Richard S.

“…Mitochondria act as potent buffers of intracellular Ca2+in many cells, but a more active role in modulating the generation of Ca2+signals is not well…”
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Single Channel Properties and Regulated Expression of Ca2+Release-Activated Ca2+(CRAC) Channels in Human T Cells by Fomina, Alla F., Fanger, Christopher M., Kozak, J. Ashot, Cahalan, Michael D.

“…Although the crucial role of Ca2+influx in lymphocyte activation has been well documented, little is known about the properties or expression levels of…”
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Characterization of T Cell Mutants with Defects in Capacitative Calcium Entry: Genetic Evidence for the Physiological Roles of CRAC Channels by Fanger, Christopher M., Hoth, Markus, Crabtree, Gerald R., Lewis, Richard S.

“…Prolonged Ca2+ influx is an essential signal for the activation of T lymphocytes by antigen. This influx is thought to occur through highly selective Ca2+…”
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Vanadate Induces Calcium Signaling, Ca2+ Release-Activated Ca2+ Channel Activation, and Gene Expression in T Lymphocytes and RBL-2H3 Mast Cells Via Thiol Oxidation by Ehring, George R, Kerschbaum, Hubert H, Fanger, Christopher M, Eder, Claudia, Rauer, Heiko, Cahalan, Michael D

“…Using ratiometric Ca2+ imaging and patch-clamp measurement of Ca2+ channel activity, we investigated Ca2+ signaling induced by vanadium compounds in Jurkat T…”
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Differential Ca2+ Influx, KCa Channel Activity, and Ca2+ Clearance Distinguish Th1 and Th2 Lymphocytes by Fanger, Christopher M, Neben, Amber L, Cahalan, Michael D

“…In Th1 and Th2 lymphocytes, activation begins with identical stimuli but results in the production of different cytokines. The expression of some cytokine…”
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MPX-004: A New Pharmacological Tool to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit by Volkmann, Robert A., Fanger, Christopher, Anderson, David R., Menniti, Frank S.

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Calcium-activated Potassium Channels Sustain Calcium Signaling in T Lymphocytes by Fanger, Christopher M., Rauer, Heiko, Neben, Amber L., Miller, Mark J., Rauer, Heike, Wulff, Heike, Rosa, Joaquin Campos, Ganellin, C.Robin, Chandy, K.George, Cahalan, Michael D.

“…To maintain Ca2+ entry during T lymphocyte activation, a balancing efflux of cations is necessary. Using three approaches, we demonstrate that this cation…”
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Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels by Fanger, C M, Rauer, H, Neben, A L, Miller, M J, Wulff, H, Rosa, J C, Ganellin, C R, Chandy, K G, Cahalan, M D

“…To maintain Ca(2+) entry during T lymphocyte activation, a balancing efflux of cations is necessary. Using three approaches, we demonstrate that this cation…”
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MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit: e0148129 by Volkmann, Robert A, Fanger, Christopher M, Anderson, David R, Sirivolu, Venkata Ramana, Paschetto, Kathy, Gordon, Earl, Virginio, Caterina, Gleyzes, Melanie, Buisson, Bruno, Steidl, Esther

“…GluN2A is the most abundant of the GluN2 NMDA receptor subunits in the mammalian CNS. Physiological and genetic evidence implicate GluN2A-containing receptors…”
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Calmodulin Mediates Calcium-dependent Activation of the Intermediate Conductance KCa Channel,IKCa1 by Fanger, C M, Ghanshani, S, Logsdon, N J, Rauer, H, Kalman, K, Zhou, J, Beckingham, K, Chandy, K G, Cahalan, M D, Aiyar, J

“…Small and intermediate conductance Ca 2+ -activated K + channels play a crucial role in hyperpolarizing the membrane potential of excitable and nonexcitable…”
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A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes by Ehring, G R, Kerschbaum, H H, Eder, C, Neben, A L, Fanger, C M, Khoury, R M, Negulescu, P A, Cahalan, M D

“…The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T…”
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Impact of Material Shade and Distance from Light Curing Unit Tip on the Depth of Polymerization of Composites by Faria-E-Silva, André L, Fanger, Christopher, Nguyen, Lillian, Howerton, Demetri, Pfeifer, Carmem S

“…This study aimed to evaluate the effect of the composite shade and distance from the light-curing unit (LCU) tip on the irradiance reaching the bottom of…”
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