Search Results - "Fang, Zhenhao"

Two Distinct Structures of Membrane‐Associated Homodimers of GTP‐ and GDP‐Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement by Lee, Ki‐Young, Fang, Zhenhao, Enomoto, Masahiro, Gasmi‐Seabrook, Genevieve, Zheng, Le, Koide, Shohei, Ikura, Mitsuhiko, Marshall, Christopher B.

“…KRAS homo‐dimerization has been implicated in the activation of RAF kinases, however, the mechanism and structural basis remain elusive. We developed a system…”
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Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site by Fang, Zhenhao, Marshall, Christopher B, Nishikawa, Tadateru, Gossert, Alvar D, Jansen, Johanna M, Jahnke, Wolfgang, Ikura, Mitsuhiko

“…KRAS is frequently mutated in several of the most lethal types of cancer; however, the KRAS protein has proven a challenging drug target. K-RAS4B must be…”
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Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617 by Peng, Lei, Hu, Yingxia, Mankowski, Madeleine C., Ren, Ping, Chen, Rita E., Wei, Jin, Zhao, Min, Li, Tongqing, Tripler, Therese, Ye, Lupeng, Chow, Ryan D., Fang, Zhenhao, Wu, Chunxiang, Dong, Matthew B., Cook, Matthew, Wang, Guilin, Clark, Paul, Nelson, Bryce, Klein, Daryl, Sutton, Richard, Diamond, Michael S., Wilen, Craig B., Xiong, Yong, Chen, Sidi

“…COVID-19 pathogen SARS-CoV-2 has infected hundreds of millions and caused over 5 million deaths to date. Although multiple vaccines are available, breakthrough…”
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Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2 by Fang, Zhenhao, Peng, Lei, Filler, Renata, Suzuki, Kazushi, McNamara, Andrew, Lin, Qianqian, Renauer, Paul A., Yang, Luojia, Menasche, Bridget, Sanchez, Angie, Ren, Ping, Xiong, Qiancheng, Strine, Madison, Clark, Paul, Lin, Chenxiang, Ko, Albert I., Grubaugh, Nathan D., Wilen, Craig B., Chen, Sidi

“…The Omicron variant of SARS-CoV-2 recently swept the globe and showed high level of immune evasion. Here, we generate an Omicron-specific lipid nanoparticle…”
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Bivalent mRNA vaccine booster induces robust antibody immunity against Omicron lineages BA.2, BA.2.12.1, BA.2.75 and BA.5 by Fang, Zhenhao, Monteiro, Valter S., Hahn, Anne M., Grubaugh, Nathan D., Lucas, Carolina, Chen, Sidi

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NMR in integrated biophysical drug discovery for RAS: past, present, and future by Marshall, Christopher B., KleinJan, Fenneke, Gebregiworgis, Teklab, Lee, Ki-Young, Fang, Zhenhao, Eves, Ben J., Liu, Ningdi F., Gasmi-Seabrook, Geneviève M. C., Enomoto, Masahiro, Ikura, Mitsuhiko

“…Mutations in RAS oncogenes occur in ~ 30% of human cancers, with KRAS being the most frequently altered isoform. RAS proteins comprise a conserved GTPase…”
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Machine learning identifies T cell receptor repertoire signatures associated with COVID-19 severity by Park, Jonathan J., Lee, Kyoung A V., Lam, Stanley Z., Moon, Katherine S., Fang, Zhenhao, Chen, Sidi

“…T cell receptor (TCR) repertoires are critical for antiviral immunity. Determining the TCR repertoire composition, diversity, and dynamics and how they change…”
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Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages by Ren, Ping, Hu, Yingxia, Peng, Lei, Yang, Luojia, Suzuki, Kazushi, Fang, Zhenhao, Bai, Meizhu, Zhou, Liqun, Feng, Yanzhi, Zou, Yongji, Xiong, Yong, Chen, Sidi

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Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2 by Fang, Zhenhao, Peng, Lei, Lucas, Carolina, Lin, Qianqian, Zhou, Liqun, Yang, Luojia, Feng, Yanzhi, Ren, Ping, Renauer, Paul A., Monteiro, Valter S., Hahn, Anne M., Park, Jonathan J., Zhou, Xiaoyu, Grubaugh, Nathan D., Wilen, Craig B., Chen, Sidi

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Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens by Fang, Zhenhao, Monteiro, Valter S., Renauer, Paul A., Shang, Xingbo, Suzuki, Kazushi, Ling, Xinyu, Bai, Meizhu, Xiang, Yan, Levchenko, Andre, Booth, Carmen J., Lucas, Carolina, Chen, Sidi

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Pretreatment neutrophil-to-lymphocyte ratio predicts the benefit of gastric cancer patients with systemic therapy by Du, Songtao, Fang, Zhenhao, Ye, Lin, Sun, Huiyan, Deng, Guangtong, Wu, Wei, Zeng, Furong

“…Pretreatment neutrophil-to-lymphocyte ratio (NLR) has been reported to be associated with the prognosis of inoperable gastric cancer patients with systemic…”
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Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane by Fang, Zhenhao, Lee, Ki-Young, Huo, Ku-Geng, Gasmi-Seabrook, Geneviève, Zheng, Le, Moghal, Nadeem, Tsao, Ming-Sound, Ikura, Mitsuhiko, Marshall, Christopher B.

“…Membrane anchoring of farnesylated KRAS is critical for activation of RAF kinases, yet our understanding of how these proteins interact on the membrane is…”
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Abstract 2041: Genetic profiling of DNA damage repair genes in hepatobiliary cancer by Fang, Zhenhao, Ou, Qiuxiang, Liu, Rui, Bao, Hua, Wu, Xue, Shao, Yang

“…Abstract Background: Hepatobiliary cancers are genetically and clinically heterogenous. Current precision therapy for hepatobiliary cancers is limited and only…”
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Genomic profiling of biliary tract cancers to reveal clinically actionable genes and therapeutic biomarkers by Shao, Yang, Ou, Qiuxiang, Fang, Zhenhao, Liu, Rui, Bao, Hua, Wu, Xue

“…Abstract only e16187 Background: Bile tract cancers are genetically and clinically heterogenous with a poor prognosis. Identifying novel biomarkers for…”
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RAMIHM generates fully human monoclonal antibodies by rapid mRNA immunization of humanized mice and BCR-seq by Ren, Ping, Peng, Lei, Yang, Luojia, Suzuki, Kazushi, Fang, Zhenhao, Renauer, Paul A, Lin, Qianqian, Bai, Meizhu, Li, Tongqing, Clark, Paul, Klein, Daryl, Chen, Sidi

“…As a clinical vaccine, lipid nanoparticle (LNP) mRNA has demonstrated potent and broad antibody responses, leading to speculation about its potential for…”
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Structural Studies of Membrane-tethered KRAS4b Interaction with RAF and Inhibitors, and RIT1 Disease Mutants by Fang, Zhenhao

“…For more than three decades, RAS genes have been recognized as among the most important cancer-causing genes. RAS mutations are found in some of the most…”
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Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species by Peng, Lei, Fang, Zhenhao, Renauer, Paul A., McNamara, Andrew, Park, Jonathan J., Lin, Qianqian, Zhou, Xiaoyu, Dong, Matthew B., Zhu, Biqing, Zhao, Hongyu, Wilen, Craig B., Chen, Sidi

“…Although COVID-19 vaccines have been developed, multiple pathogenic coronavirus species exist, urging on development of multispecies coronavirus vaccines. Here…”
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Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids by Gebregiworgis, Teklab, Marshall, Christopher B, Nishikawa, Tadateru, Radulovich, Nikolina, Sandí, María-José, Fang, Zhenhao, Rottapel, Robert, Tsao, Ming-Sound, Ikura, Mitsuhiko

“…Small GTPases (sGTPases) are critical switch-like regulators that mediate several important cellular functions and are often mutated in human cancers. They are…”
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Genomic Correlates of Unfavorable Outcome in Locally Advanced Cervical Cancer Treated with Neoadjuvant Chemoradiation by Wei, Yuchun, Wei, Chuqing, Chen, Liang, Liu, Ning, Ou, Qiuxiang, Yin, Jiani C, Pang, Jiaohui, Fang, Zhenhao, Wu, Xue, Wang, Xiaonan, Mu, Dianbin, Shao, Yang, Yu, Jinming, Yuan, Shuanghu

“…Neoadjuvant therapy modality can increase the operability rate and mitigate pathological risks in locally advanced cervical cancer, but treatment response…”
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Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1) by Fang, Zhenhao, Marshall, Christopher B., Yin, Jiani C., Mazhab-Jafari, Mohammad T., Gasmi-Seabrook, Geneviève M.C., Smith, Matthew J., Nishikawa, Tadateru, Xu, Yang, Neel, Benjamin G., Ikura, Mitsuhiko

“…RAS-like protein expressed in many tissues 1 (RIT1) is a disease-associated RAS subfamily small guanosine triphosphatase (GTPase). Recent studies revealed that…”
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