Search Results - "Fang, Zhenghuan"

Tumor vessel normalization by the PI3K inhibitor HS-173 enhances drug delivery by Kim, Soo Jung, Jung, Kyung Hee, Son, Mi Kwon, Park, Jung Hee, Yan, Hong Hua, Fang, Zhenghuan, Kang, Yeo Wool, Han, Boreum, Lim, Joo Han, Hong, Soon-Sun

“…Tumor vessels are leaky and immature, which causes poor oxygen and nutrient supply to tumor vessels and results in cancer cell metastasis to distant organs…”
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ATP10B variants in Parkinson’s disease: a large cohort study in Chinese mainland population by Zhao, Yuwen, Pan, Hongxu, Wang, Yige, Zeng, Qian, Fang, Zhenghuan, He, Runcheng, Xu, Kun, Zhou, Xiaoxia, Zhou, Xun, Zhou, Zhou, Li, Yanghong, Deng, Penghui, Xu, Yinghui, Xu, Qian, Sun, Qiying, Li, Bin, Zhao, Guihu, Lei, Lifang, Zhang, Hainan, Wang, Chunyu, Tan, Jieqiong, Yan, Xinxiang, Shen, Lu, Jiang, Hong, Li, Jinchen, Guo, Jifeng, Tang, Beisha, Liu, Zhenhua

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Cross-Disorder Analysis of De Novo Mutations in Neuropsychiatric Disorders by Li, Kuokuo, Fang, Zhenghuan, Zhao, Guihu, Li, Bin, Chen, Chao, Xia, Lu, Wang, Lin, Luo, Tengfei, Wang, Xiaomeng, Wang, Zheng, Zhang, Yi, Jiang, Yi, Pan, Qian, Hu, Zhengmao, Guo, Hui, Tang, Beisha, Liu, Chunyu, Sun, Zhongsheng, Xia, Kun, Li, Jinchen

“…The clinical similarity among different neuropsychiatric disorders (NPDs) suggested a shared genetic basis. We catalogued 23,109 coding de novo mutations…”
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Systemic and Local Metabolic Alterations in Sleep-Deprivation-Induced Stress: A Multiplatform Mass-Spectrometry-Based Lipidomics and Metabolomics Approach by Yoon, Sang Jun, Long, Nguyen Phuoc, Jung, Kyung-Hee, Kim, Hyung Min, Hong, Yu Jin, Fang, Zhenghuan, Kim, Sun Jo, Kim, Tae Joon, Anh, Nguyen Hoang, Hong, Soon-Sun, Kwon, Sung Won

“…Sleep deprivation (SD) is known to be associated with metabolic disorders and chronic diseases. Complex metabolic alterations induced by SD at omics scale and…”
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De novo mutation of cancer-related genes associates with particular neurodevelopmental disorders by Li, Bin, Li, Kuokuo, Tian, Di, Zhou, Qiao, Xie, Yali, Fang, Zhenghuan, Wang, Xiaomeng, Luo, Tengfei, Wang, Zheng, Zhang, Yi, Wang, Yijing, Chen, Qian, Meng, Qingtuan, Zhao, Guihu, Li, Jinchen

“…Epidemiological studies have shown an increased prevalence of cancer in some patients with neurodevelopmental disorder (NDD); however, the genetic mechanisms…”
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Synthesis of Gemcitabine-Threonine Amide Prodrug Effective on Pancreatic Cancer Cells with Improved Pharmacokinetic Properties by Hong, Sungwoo, Fang, Zhenghuan, Jung, Hoi-Yun, Yoon, Jin-Ha, Hong, Soon-Sun, Maeng, Han-Joo

“…To investigate the amino acid transporter-based prodrug anticancer strategy further, several amino acid-conjugated amide gemcitabine prodrugs were synthesized…”
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Selonsertib Inhibits Liver Fibrosis via Downregulation of ASK1/ MAPK Pathway of Hepatic Stellate Cells by Yoon, Young-Chan, Fang, Zhenghuan, Lee, Ji Eun, Park, Jung Hee, Ryu, Ji-Kan, Jung, Kyung Hee, Hong, Soon-Sun

“…Liver fibrosis constitutes a significant health problem worldwide due to its rapidly increasing prevalence and the absence of specific and effective…”
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Gene4PD: A Comprehensive Genetic Database of Parkinson's Disease by Li, Bin, Zhao, Guihu, Zhou, Qiao, Xie, Yali, Wang, Zheng, Fang, Zhenghuan, Lu, Bin, Qin, Lixia, Zhao, Yuwen, Zhang, Rui, Jiang, Li, Pan, Hongxu, He, Yan, Wang, Xiaomeng, Luo, Tengfei, Zhang, Yi, Wang, Yijing, Chen, Qian, Liu, Zhenhua, Guo, Jifeng, Tang, Beisha, Li, Jinchen

“…Parkinson's disease (PD) is a complex neurodegenerative disorder with a strong genetic component. A growing number of variants and genes have been reported to…”
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Performance Comparison of Computational Methods for the Prediction of the Function and Pathogenicity of Non-coding Variants by Wang, Zheng, Zhao, Guihu, Li, Bin, Fang, Zhenghuan, Chen, Qian, Wang, Xiaomeng, Luo, Tengfei, Wang, Yijing, Zhou, Qiao, Li, Kuokuo, Xia, Lu, Zhang, Yi, Zhou, Xun, Pan, Hongxu, Zhao, Yuwen, Wang, Yige, Wang, Lin, Guo, Jifeng, Tang, Beisha, Xia, Kun, Li, Jinchen

“…Non-coding variants in the human genome significantly influence human traits and complex diseases via their regulation and modification effects. Hence, an…”
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Characterizing the Expression Patterns of Parkinson's Disease Associated Genes by Li, Bin, Zhao, Guihu, Li, Kuokuo, Wang, Zheng, Fang, Zhenghuan, Wang, Xiaomeng, Luo, Tengfei, Zhang, Yi, Wang, Yijing, Chen, Qian, Huang, Yuanfeng, Dong, Lijie, Guo, Jifeng, Tang, Beisha, Li, Jinchen

“…The expression pattern represents a quantitative phenotype that provides an in-depth view of the molecular mechanism in Parkinson's disease (PD); however, the…”
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ANGPTL4 exacerbates pancreatitis by augmenting acinar cell injury through upregulation of C5a by Jung, Kyung Hee, Son, Mi Kwon, Yan, Hong Hua, Fang, Zhenghuan, Kim, Juyoung, Kim, Soo Jung, Park, Jung Hee, Lee, Ji Eun, Yoon, Young‐Chan, Seo, Myeong Seong, Han, Beom Seok, Ko, Soyeon, Suh, Young Ju, Lim, Joo Han, Lee, Don‐Haeng, Teo, Ziqiang, Wee, Jonathan Wei Kiat, Tan, Nguan Soon, Hong, Soon‐Sun

“…Pancreatitis is the inflammation of the pancreas. However, little is known about the genes associated with pancreatitis severity. Our microarray analysis of…”
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MEK blockade overcomes the limited activity of palbociclib in head and neck cancer by Fang, Zhenghuan, Jung, Kyung Hee, Lee, Ji Eun, Cho, Jinhyun, Lim, Joo Han, Hong, Soon-Sun

“…Head and neck cancer (HNC) is characterized with multiple aberrations in cell cycle pathways, including amplification of cyclin D1. Palbociclib (PAL), a…”
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Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-β/STAT3 Pathway by Fang, Zhenghuan, Jung, Kyung Hee, Yan, Hong Hua, Kim, Soo-Jung, Rumman, Marufa, Park, Jung Hee, Han, Boreum, Lee, Ji Eun, Kang, Yeo wool, Lim, Joo Han, Hong, Soon Sun

“…Background/Aims: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant tumors with poor prognosis. Conventional chemotherapies including…”
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Profiling the Genome-Wide Landscape of Short Tandem Repeats by Long-Read Sequencing by Liu, Zhenhua, Zhao, Guihu, Xiao, Yuhui, Zeng, Sheng, Yuan, Yanchun, Zhou, Xun, Fang, Zhenghuan, He, Runcheng, Li, Bin, Zhao, Yuwen, Pan, Hongxu, Wang, Yige, Yu, Guoliang, Peng, I-Feng, Wang, Depeng, Meng, Qingtuan, Xu, Qian, Sun, Qiying, Yan, Xinxiang, Shen, Lu, Jiang, Hong, Xia, Kun, Wang, Junling, Guo, Jifeng, Liang, Fan, Li, Jinchen, Tang, Beisha

“…Short tandem repeats (STRs) are highly variable elements that play a pivotal role in multiple genetic diseases and the regulation of gene expression. Long-read…”
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PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis by Kim, Juyoung, Jung, Kyung Hee, Yoo, Jaeho, Park, Jung Hee, Yan, Hong Hua, Fang, Zhenghuan, Lim, Joo Han, Kwon, Seong-Ryul, Kim, Myung Ku, Park, Hyun-Ju, Hong, Soon-Sun

“…Phosphoinositide 3-kinase (PI3K) is considered as a promising therapeutic target for rheumatoid arthritis (RA) because of its involvement in inflammatory…”
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Functional relationships between recessive inherited genes and genes with de novo variants in autism spectrum disorder by Wang, Lin, Zhang, Yi, Li, Kuokuo, Wang, Zheng, Wang, Xiaomeng, Li, Bin, Zhao, Guihu, Fang, Zhenghuan, Ling, Zhengbao, Luo, Tengfei, Xia, Lu, Li, Yanping, Guo, Hui, Hu, Zhengmao, Li, Jinchen, Sun, Zhongsheng, Xia, Kun

“…Abstract Background Both de novo variants and recessive inherited variants were associated with autism spectrum disorder (ASD). This study aimed to use exome…”
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GPCards: An integrated database of genotype–phenotype correlations in human genetic diseases by Li, Bin, Wang, Zheng, Chen, Qian, Li, Kuokuo, Wang, Xiaomeng, Wang, Yijing, Zeng, Qian, Han, Ying, Lu, Bin, Zhao, Yuwen, Zhang, Rui, Jiang, Li, Pan, Hongxu, Luo, Tengfei, Zhang, Yi, Fang, Zhenghuan, Xiao, Xuewen, Zhou, Xun, Wang, Rui, Zhou, Lu, Wang, Yige, Yuan, Zhenhua, Xia, Lu, Guo, Jifeng, Tang, Beisha, Xia, Kun, Zhao, Guihu, Li, Jinchen

“…•The patient-level genotype-phenotype correlations in GPCards accelerated the development of medical genetics.•The integrated 62 genomic sources provide…”
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De novo mutations in folate-related genes associated with common developmental disorders by Luo, Tengfei, Li, Kuokuo, Ling, Zhengbao, Zhao, Guihu, Li, Bin, Wang, Zheng, Wang, Xiaomeng, Han, Ying, Xia, Lu, Zhang, Yi, Zhou, Qiao, Fang, Zhenghuan, Wang, Yijing, Chen, Qian, Zhou, Xun, Pan, Hongxu, Zhao, Yuwen, Wang, Yige, Dong, Lijie, Huang, Yuanfeng, Hu, Zhengmao, Pan, Qian, Xia, Kun, Li, Jinchen

“…[Display omitted] Folate deficiency is an environmental risk factor for several developmental disorders. De novo mutations (DNMs) also play important…”
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HS-104, a PI3K inhibitor, enhances the anticancer efficacy of gemcitabine in pancreatic cancer by JUNG, KYUNG HEE, YAN, HONG HUA, FANG, ZHENGHUAN, SON, MI KWON, LEE, HYUNSEUNG, HONG, SUNGWOO, HONG, SOON-SUN

“…Gemcitabine has limited clinical benefits for pancreatic cancer patients. The phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway is important in cell…”
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Selonsertib Inhibits Liver Fibrosis via Downregulation of ASK1/ MAPK Pathway of Hepatic Stellate Cells by Yoon, Young-Chan, Fang, Zhenghuan, Lee, Ji Eun, Park, Jung Hee, Ryu, Ji-Kan, Jung, Kyung Hee, Hong, Soon-Sun

“…Liver fibrosis constitutes a significant health problem worldwide due to its rapidly increasing prevalence and the absence of specific and effective…”
Get full text