Search Results - "Fang, Yong Hu"

Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension by Marsboom, Glenn, Toth, Peter T, Ryan, John J, Hong, Zhigang, Wu, Xichen, Fang, Yong-Hu, Thenappan, Thenappan, Piao, Lin, Zhang, Hannah J, Pogoriler, Jennifer, Chen, Yimei, Morrow, Erik, Weir, E Kenneth, Rehman, Jalees, Archer, Stephen L

“…RATIONALE:Pulmonary arterial hypertension (PAH) is a lethal syndrome characterized by pulmonary vascular obstruction caused, in part, by pulmonary artery…”
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Effects of CYP2C19 loss-of-function variants on the eradication of H. pylori infection in patients treated with proton pump inhibitor-based triple therapy regimens: a meta-analysis of randomized clinical trials by Tang, Hui-Lin, Li, Yan, Hu, Yong-Fang, Xie, Hong-Guang, Zhai, Suo-Di

“…There are inconsistent conclusions about whether CYP2C19 variants could affect H. pylori eradication rate in patients treated with the proton pump inhibitor…”
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Dynamin‐related protein 1 is a critical regulator of mitochondrial calcium homeostasis during myocardial ischemia/reperfusion injury by Piao, Lin, Fang, Yong‐Hu, Fisher, Michael, Hamanaka, Robert B., Ousta, Alaa, Wu, Rongxu, Mutlu, Gökhan M., Garcia, Alfredo J., Archer, Stephen L., Sharp, Willard W.

“…Dynamin‐related protein 1 (Drp1) is a cytosolic GTPase protein that when activated translocates to the mitochondria, meditating mitochondrial fission and…”
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Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension by Piao, Lin, Fang, Yong-Hu, Parikh, Kishan, Ryan, John J., Toth, Peter T., Archer, Stephen L.

“…The rapid growth of cancer cells is permitted by metabolic changes, notably increased aerobic glycolysis and increased glutaminolysis. Aerobic glycolysis is…”
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Metabolism and bioenergetics in the right ventricle and pulmonary vasculature in pulmonary hypertension by Archer, Stephen L., Fang, Yong-Hu, Ryan, John J., Piao, Lin

“…Pulmonary arterial hypertension (PAH) is a syndrome in which pulmonary vascular cross sectional area and compliance are reduced by vasoconstriction, vascular…”
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Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle’s cycle by Fang, Yong-Hu, Piao, Lin, Hong, Zhigang, Toth, Peter T., Marsboom, Glenn, Bache-Wiig, Peter, Rehman, Jalees, Archer, Stephen L.

“…Right ventricular hypertrophy (RVH) and RV failure are major determinants of prognosis in pulmonary hypertension and congenital heart disease. In RVH, there is…”
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Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension by Urboniene, Dalia, Haber, Idith, Fang, Yong-Hu, Thenappan, Thenappan, Archer, Stephen L

“…High-frequency echocardiography and high-field-strength magnetic resonance imaging (MRI) are new noninvasive methods for quantifying pulmonary arterial…”
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Maternal zinc deficiency during pregnancy elevates the risks of fetal growth restriction: a population-based birth cohort study by Wang, Hua, Hu, Yong-Fang, Hao, Jia-Hu, Chen, Yuan-Hua, Su, Pu-Yu, Wang, Ying, Yu, Zhen, Fu, Lin, Xu, Yuan-Yuan, Zhang, Cheng, Tao, Fang-Biao, Xu, De-Xiang

“…We investigated the association between maternal zinc level during pregnancy and the risks of low birth weight (LBW) and small for gestational age (SGA)…”
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Enhanced pyruvate dehydrogenase activity improves cardiac outcomes in a murine model of cardiac arrest by Piao, Lin, Fang, Yong-Hu, Kubler, Manfred M, Donnino, Michael W, Sharp, Willard W

“…Post-ischemic changes in cellular metabolism alter myocardial and neurological function. Pyruvate dehydrogenase (PDH), the limiting step in mitochondrial…”
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The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle by Piao, Lin, Fang, Yong-Hu, Cadete, Virgilio J. J., Wietholt, Christian, Urboniene, Dalia, Toth, Peter T., Marsboom, Glenn, Zhang, Hannah J., Haber, Idith, Rehman, Jalees, Lopaschuk, Gary D., Archer, Stephen L.

“…Right ventricular hypertrophy (RVH) and RV failure contribute to morbidity and mortality in pulmonary arterial hypertension (PAH). The cause of RV dysfunction…”
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Maternal LPS exposure during pregnancy impairs testicular development, steroidogenesis and spermatogenesis in male offspring by Wang, Hua, Yang, Lu-Lu, Hu, Yong-Fang, Wang, Bi-Wei, Huang, Yin-Yin, Zhang, Cheng, Chen, Yuan-Hua, Xu, De-Xiang

“…Lipopolysaccharide (LPS) is associated with adverse developmental outcomes including embryonic resorption, fetal death, congenital teratogenesis and fetal…”
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Lower tacrolimus daily dose requirements and acute rejection rates in the CYP3A5 nonexpressers than expressers by Tang, Hui-Lin, Xie, Hong-Guang, Yao, Yao, Hu, Yong-Fang

“…BACKGROUNDCYP3A5 genetic polymorphisms contribute to marked interindividual differences in the metabolism of and response to tacrolimus in humans…”
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Incorporation of Gene‐Environment Interaction Terms Improved the Predictive Accuracy of Tacrolimus Stable Dose Algorithms in Chinese Adult Renal Transplant Recipients by Tang, Jie, Xu, Jing, Zhang, Yue‐Li, Liu, Rong, Liu, Mou‐Ze, Hu, Yong‐Fang, Shao, Ming‐Jie, Zhu, Li‐Jun, Cao, Shan, Xin, Hua‐Wen, Feng, Gui‐Wen, Shang, Wen‐Jun, Meng, Xiang‐Guang, Zhang, Li‐Rong, Ming, Ying‐Zi, Zhang, Wei, Zhou, Gan

“…The narrow therapeutic window of tacrolimus necessitates daily monitoring and predictive algorithms based on genetic and nongenetic factors. In this study, we…”
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Regeneration of ischemic heart using hyaluronic acid-based injectable hydrogel by Yoon, So Jeong, Fang, Yong Hu, Lim, Choon Hak, Kim, Bum Shik, Son, Ho Sung, Park, Yongdoo, Sun, Kyung

“…An injectable hydrogel was applied to regenerate a myocardial infarction and functional recovery of the heart. A myocardial infarction was induced in rat by…”
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Factors associated with development of re-nonunion after primary revision in femoral shaft nonunion subsequent to failed intramedullary nailing by Ru, Jiang-Ying, Chen, Li-Xin, Hu, Fang-Yong, Shi, Dai, Xu, Rao, Du, Jian-Wei, Niu, Yun-Fei

“…Currently, there remains a lack of consensus regarding factors predictive of complication such as re-nonunion after primary revision in femoral shaft nonunion…”
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IL-3 and CTLA4 gene polymorphis.ms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients by Liu, Mou-ze, He, Hai-yan, Zhang, Yue-li, Hu, Yong-fang, He, Fa-zhong, Luo, Jian-quan, Luo, Zhi-ying, Chen, Xiao-ping, Liu, Zhao-qian, Zhou, Hong-hao, Shao, Ming-jie, Ming, Ying-zi, Xin, Hua-wen, Zhang, Wei

“…The highly variable pharmacokinetics and narrow therapeutic window of tacrolimus （TAC） has hampered its clinical use. Genetic polymorphisms may contribute to…”
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Cadmium selectively induces MIP-2 and COX-2 through PTEN-mediated Akt activation in RAW264.7 cells by Huang, Yin-Yin, Xia, Mi-Zhen, Wang, Hua, Liu, Xiao-Jing, Hu, Yong-Fang, Chen, Yuan-Hua, Zhang, Cheng, Xu, De-Xiang

“…Increasing evidence demonstrates that cadmium (Cd) induces inflammation, but its mechanisms remain obscure. The present study showed that treatment with CdCl₂…”
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Differential regeneration of myocardial infarction depending on the progression of disease and the composition of biomimetic hydrogel by Yoon, So Jeong, Hong, Soyoung, Fang, Yong Hu, Song, Myeongjin, Son, Kuk Hui, Son, Ho Sung, Kim, Sook Kyoung, Sun, Kyung, Park, Yongdoo

“…Hydrogel has been used for regenerating myocardial infraction (MI) as a delivery vehicle for cells and growth factors. This study showed that injectable…”
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FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate by Piao, Lin, Sidhu, Vaninder K., Fang, Yong-Hu, Ryan, John J., Parikh, Kishan S., Hong, Zhigang, Toth, Peter T., Morrow, Erik, Kutty, Shelby, Lopaschuk, Gary D., Archer, Stephen L.

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EFFECTS OF GENETIC POLYMORPHISMS OF CYP3A4, CYP3A5 AND MDR1 ON CYCLOSPORINE PHARMACOKINETICS AFTER RENAL TRANSPLANTATION by Hu, Yong‐Fang, Qiu, Wen, Liu, Zhao‐Qian, Zhu, Li‐Jun, Liu, Zhong‐Qi, Tu, Jiang‐Hua, Wang, Dan, Li, Zhi, He, Jun, Zhong, Gan‐Ping, Zhou, Gan, Zhou, Hong‐Hao

“…SUMMARY 1 The calcineurin inhibitor cyclosporine is widely used to prevent allograft rejection after solid organ transplantation. It has a narrow therapeutic…”
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