Search Results - "Fang, Xiefan"

Nucleolin targeting AS1411 aptamer modified pH-sensitive micelles for enhanced delivery and antitumor efficacy of paclitaxel by Zhang, Jinming, Chen, Ruie, Fang, Xiefan, Chen, Fengqian, Wang, Yitao, Chen, Meiwan

“…Targeted drug delivery coupled with rapid drug release in cytoplasm is a powerful strategy to enhance efficacy and reduce off-target effects of anti-cancer…”
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Cucurbitacins: A Systematic Review of the Phytochemistry and Anticancer Activity by Cai, Yuee, Fang, Xiefan, He, Chengwei, Li, Peng, Xiao, Fei, Wang, Yitao, Chen, Meiwan

“…Cucurbitacins are highly oxidized tetracyclic triterpenoids that are widely present in traditional Chinese medicines (Cucurbitaceae family), possess strong…”
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Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review) by YANG, SHENG-LI, WU, CHAO, XIONG, ZHI-FAN, FANG, XIEFAN

“…Hypoxia inducible factors (HIFs) are transcription factors, which are commonly expressed in mammals, including humans. The HIFs consist of hypoxia-regulated α…”
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Regulation of Obesity and Metabolic Complications by Gamma and Delta Tocotrienols by Zhao, Lu, Fang, Xiefan, Marshall, Maurice R, Chung, Soonkyu

“…Tocotrienols (T3s) are a subclass of unsaturated vitamin E that have been extensively studied for their anti-proliferative, anti-oxidative and…”
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Global and gene specific DNA methylation changes during zebrafish development by Fang, Xiefan, Corrales, Jone, Thornton, Cammi, Scheffler, Brian E., Willett, Kristine L.

“…DNA methylation is dynamic through the life of an organism. Previous studies have primarily focused on DNA methylation changes during very early embryogenesis…”
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Knockdown of DNA methyltransferase 3a alters gene expression and inhibits function of embryonic cardiomyocytes by Fang, Xiefan, Poulsen, Ryan R., Wang‐Hu, John, Shi, Olivia, Calvo, Nicholas S., Simmons, Chelsey S., Rivkees, Scott A., Wendler, Christopher C.

“…ABSTRACT We previously found that in utero caffeine exposure causes down‐regulation of DNA methyltransferases (DNMTs) in embryonic heart and results in…”
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Separation and identification of underivatized plasma acylcarnitine isomers using liquid chromatography–tandem mass spectrometry for the differential diagnosis of organic acidemias and fatty acid oxidation defects by Peng, Minzhi, Fang, Xiefan, Huang, Yonglan, Cai, Yanna, Liang, Cuili, Lin, Ruizhu, Liu, Li

“…•We developed a HPLC–MS/MS method to separate and identify acylcarnitine isomers.•Acylcarnitines were detected without derivatization.•Stereoisomers were…”
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Embryonic caffeine exposure acts via A1 adenosine receptors to alter adult cardiac function and DNA methylation in mice by Buscariollo, Daniela L, Fang, Xiefan, Greenwood, Victoria, Xue, Huiling, Rivkees, Scott A, Wendler, Christopher C

“…Evidence indicates that disruption of normal prenatal development influences an individual's risk of developing obesity and cardiovascular disease as an adult…”
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Positive Expression of Programmed Death Ligand 1 in Peritumoral Liver Tissue is Associated with Poor Survival after Curative Resection of Hepatocellular Carcinoma by Dai, Xiaomeng, Xue, Jun, Hu, Jianli, Yang, Sheng-li, Chen, George G, Lai, Paul B.S, Yu, Chao, Zeng, Cui, Fang, Xiefan, Pan, Xiaoli, Zhang, Tao

“…Abstract BACKGROUND: Recurrence or metastasis of hepatocellular carcinoma (HCC) is mainly intrahepatic after curative resection, demonstrating that the…”
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Knockdown of DNA methyltransferase 1 reduces DNA methylation and alters expression patterns of cardiac genes in embryonic cardiomyocytes by Fang, Xiefan, Poulsen, Ryan, Zhao, Lu, Wang, Jingjing, Rivkees, Scott A., Wendler, Christopher C.

“…We previously found that DNA methyltransferase 3a (DNMT3a) plays an important role in regulating embryonic cardiomyocyte gene expression, morphology, and…”
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Hypoxia disrupts the expression levels of circadian rhythm genes in hepatocellular carcinoma by YU, CHAO, YANG, SHENG-LI, FANG, XIEFAN, JIANG, JIAN-XIN, SUN, CHENG-YI, HUANG, TAO

“…Disturbance in the expression of circadian rhythm genes is a common feature in certain types of cancer, however the mechanisms mediating this disturbance…”
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Bumetanide increases Cl--dependent short-circuit current in late distal colon: Evidence for the presence of active electrogenic Cl- absorption by Tang, Lieqi, Fang, Xiefan, Winesett, Steven P, Cheng, Catherine Y, Binder, Henry J, Rivkees, Scott A, Cheng, Sam X

“…Mammalian colonic epithelia consist of cells that are capable of both absorbing and secreting Cl-. The present studies employing Ussing chamber technique…”
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Benzo[a]pyrene effects on glycine N-methyltransferase mRNA expression and enzyme activity in Fundulus heteroclitus embryos by Fang, Xiefan, Dong, Wu, Thornton, Cammi, Willett, Kristine L.

“…Benzo[a]pyrene (BaP) is a ubiquitous environmental polycyclic aromatic hydrocarbon (PAH) contaminant that is both a carcinogen and a developmental toxicant. We…”
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Hepatitis B virus X protein disrupts the balance of the expression of circadian rhythm genes in hepatocellular carcinoma by YANG, SHENG-LI, YU, CHAO, JIANG, JIAN-XIN, LIU, LI-PING, FANG, XIEFAN, WU, CHAO

“…The human circadian rhythm is controlled by at least eight circadian clock genes and disruption of the circadian rhythm is associated with cancer development…”
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AT1 angiotensin II receptor and novel non-AT1 , non-AT2 angiotensin II/III binding site in brainstem cardiovascular regulatory centers of the spontaneously hypertensive rat by Bourassa, Erick A, Fang, Xiefan, Li, Xia, Sved, Alan F, Speth, Robert C

“…Abstract Spontaneously hypertensive rats (SHR) have an activated brain angiotensin system that contributes to the elevation of blood pressure in this animal…”
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Gene expression profile and molecular pathway datasets resulting from benzo(a)pyrene exposure in the liver and testis of adult tilapia by Colli-Dula, Reyna Cristina, Fang, Xiefan, Moraga-Amador, David, Albornoz-Abud, Nacira, Zamora-Bustillos, Roberto, Conesa, Ana, Zapata-Perez, Omar, Moreno, Diego, Hernandez-Nuñez, Emanuel

“…Benzo(a)pyrene (BaP), the prototype of polycyclic aromatic hydrocarbons, is known to exhibits genotoxic and carcinogenic effects promoting molecular impacts…”
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A Nanoarchitectonic Approach Enables Triple Modal Synergistic Therapies To Enhance Antitumor Effects by Mo, Zhimin, Li, Qiuting, Zhao, Kan, Xu, Qi, Hu, Han, Chen, Xu, Luo, Yuxuan, Chi, Bin, Liu, Liping, Fang, Xiefan, Liao, Guangfu, Xu, Zushun, Wang, Jing, Yang, Shengli

“…Improvement of antitumor effects relies on the development of biocompatible nanomaterials and combination of various therapies to produce synergistic effects…”
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Reference intervals and method sensitivity for electrocardiology, hemodynamics, and body temperature parameters in healthy cynomolgus monkeys by Fang, Xiefan, Tichenor, Stephen D.

“…In nonclinical studies, electrocardiograms (ECG) of cynomolgus monkey are recorded intermittently by external leads in manually restrained animals (snapshot…”
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TPGS-g-PLGA/Pluronic F68 mixed micelles for tanshinone IIA delivery in cancer therapy by Zhang, Jinming, Li, Yingbo, Fang, Xiefan, Zhou, Demin, Wang, Yitao, Chen, Meiwan

“…[Display omitted] Tanshinone IIA (TAN) has few clinical applications for anti-cancer therapy mainly due to its high lipophicity, low cellular uptake, and poor…”
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Glycyrrhetinic Acid-Mediated Polymeric Drug Delivery Targeting the Acidic Microenvironment of Hepatocellular Carcinoma by Zhang, Jinming, Zhang, Min, Ji, Juan, Fang, Xiefan, Pan, Xin, Wang, Yitao, Wu, Chuanbin, Chen, Meiwan

“…ABSTRACT Purpose The major hurdle of current drug carrier against hepatocellular carcinoma (HCC) is the lack of specific and selective drug delivery to HCC. In…”
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