Search Results - "Fang, Jinzhang"

Cationic Polymethacrylate-Modified Liposomes Significantly Enhanced Doxorubicin Delivery and Antitumor Activity by Wang, Wenxi, Shao, Anna, Zhang, Nan, Fang, Jinzhang, Ruan, Jennifer Jin, Ruan, Benfang Helen

“…Liposome (LP) encapsulation of doxorubicin (DOX) is a clinically validated method for cancer drug delivery, but its cellular uptake is actually lower than the…”
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Biomolecular Interaction Assays Identified Dual Inhibitors of Glutaminase and Glutamate Dehydrogenase That Disrupt Mitochondrial Function and Prevent Growth of Cancer Cells by Zhu, Min, Fang, Jinzhang, Zhang, Jingjing, Zhang, Zheng, Xie, Jianhui, Yu, Yan, Ruan, Jennifer Jin, Chen, Zhao, Hou, Wei, Yang, Gensheng, Su, Weike, Ruan, Benfang Helen

“…Glutaminase (KGA/isoenzyme GAC) is an emerging and important drug target for cancer. Traditional methods for assaying glutaminase activity are coupled with…”
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Design and synthesis of biotinylated Hexylselen as a probe to identify KGA allosteric inhibitors by a convenient biomolecular interaction assay by Hou, Wei, Fang, Jinzhang, Su, Lin, Ye, Hengyu, Ruan, Benfang Helen

“…[Display omitted] Hexylselen is a novel submicromolar dual KGA/GDH inhibitor, which demonstrates potent inhibition of cancer cells with minimal toxicity. To…”
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Abstract 3947: Glutaminolysis inhibitors benzo[d][1,2]selenazol -3(2H)-one dimers completely disrupt mitochondrial function and showed early promise as effective antitumor agents with little general toxicity by Ruan, Benfang Helen, Yu, Yan, Chen, Zhao, Jin, Yanhong, Fang, Jinzhang, Zhao, Han, Ruan, Jennifer

“…Targeting glutaminolysis is an emerging approach to solve the imminent problems of drug resistance and drug toxicity in cancer therapeutics. Ebselen was…”
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Self-Assembled Micellar Glutaminase Allosteric Inhibitor for Effective Therapeutic Intervention by Fang, Jinzhang, Chen, Zhao, Li, Jinxiu, Li, Di, Wang, Wenxi, Ruan, Benfang Helen

“…Kidney-type glutaminase (KGA) has been an important anti-tumor drug target, and KGA allosteric inhibitors attracted much interest for their superior enzymatic…”
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Biomolecular interaction analysis for carbon nanotubes and for biocompatibility prediction by Chen, Xiaoping, Fang, Jinzhang, Cheng, Yun, Zheng, Jianhui, Zhang, Jingjing, Chen, Tao, Ruan, Benfang Helen

“…The interactions between carbon nanotubes (CNTs) and biologics have been commonly studied by various microscopy and spectroscopy methods. We tried biomolecular…”
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Biodegradable self-assembly micelles significantly enhanced the solubility, biological stability and in vivo antitumor efficacy of Hexylselen by Fang, Jinzhang, Chen, Zhao, Song, Jun, Li, Jinxiu, Han, Yunying, Hou, Wei, Wang, Wenxi, Ruan, Benfang H

“…Glutaminolysis inhibitors have shown early promise in cancer therapeutics. Specifically, kidney-type glutaminase (KGA) has been a long-standing anti-tumor drug…”
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Novel 1,3,4-Selenadiazole-Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity by Chen, Zhao, Li, Di, Xu, Ning, Fang, Jinzhang, Yu, Yan, Hou, Wei, Ruan, Haoqiang, Zhu, Panpan, Ma, Renchao, Lu, Shiying, Cao, Danhui, Wu, Rui, Ni, Mowei, Zhang, Wei, Su, Weike, Ruan, Benfang Helen

“…Kidney-type glutaminase [KGA/isoenzyme glutaminase C (GAC)] is becoming an important tumor metabolism target in cancer chemotherapy. Its allosteric inhibitor,…”
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Biodegradable self-assembly micelles significantly enhanced the solubility, biological stability and antitumor efficacy of Hexylselen by Fang, Jinzhang, Chen, Zhao, Song, Jun, Li, Jinxiu, Han, Yunying, Hou, Wei, Wang, Wenxi, Ruan, Benfang H

“…Glutaminolysis inhibitors have shown early promise in cancer therapeutics. Specifically, kidney-type glutaminase (KGA) has been a long-standing anti-tumor drug…”
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Kidney-Type Glutaminase Inhibitor Hexylselen Selectively Kills Cancer Cells via a Three-Pronged Mechanism by Ruan, Jennifer Jin, Yu, Yan, Hou, Wei, Chen, Zhao, Fang, Jinzhang, Zhang, Jingjing, Ni, Muowei, Li, Di, Lu, Shiying, Rui, Jingjing, Wu, Rui, Zhang, Wei, Ruan, Benfang Helen

“…Tumor metabolism has been deeply investigated for cancer therapeutics. Here, we demonstrate that glutamine deficiency alone could not completely inhibit cancer…”
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