Comparison of sevoflurane and isoflurane in dogs anaesthetised for clinical surgical or diagnostic procedures

To assess attributes of sevoflurane for routine clinical anaesthesia in dogs by comparison with the established volatile anaesthetic isoflurane. One hundred and eight dogs requiring anaesthesia for elective surgery or diagnostic procedures were studied. The majority was premedicated with 0·03 mg/kg...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of small animal practice Vol. 49; no. 8; pp. 392 - 397
Main Authors:	Bennett, R.C, Fancy, S.P.J, Walsh, C.M, Brown, A.J, Taylor, P.M
Format:	Journal Article
Language:	English
Published:	Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01-08-2008 Blackwell Publishing Ltd
Subjects:	adverse effects anesthesia Anesthesia Recovery Period Anesthetics, Inhalation Animals blood pressure Blood Pressure - drug effects body temperature breathing Carbon Dioxide - blood cardiovascular system depth of anesthesia dogs Dogs - physiology drug evaluation England general anesthetics heart rate Heart Rate - drug effects hemoglobin Isoflurane Methyl Ethers Monitoring, Physiologic - veterinary pharmacokinetics Preanesthetic Medication - veterinary Respiration - drug effects respiratory gases risk assessment sevoflurane surgery Treatment Outcome veterinary drugs England
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	To assess attributes of sevoflurane for routine clinical anaesthesia in dogs by comparison with the established volatile anaesthetic isoflurane. One hundred and eight dogs requiring anaesthesia for elective surgery or diagnostic procedures were studied. The majority was premedicated with 0·03 mg/kg of acepromazine and 0·01 mg/kg of buprenorphine or 0·3 mg/kg of methadone before induction of anaesthesia with 2 to 4 mg/kg of propofol and 0·5 mg/kg of diazepam. They were randomly assigned to receive either sevoflurane (group S, n=50) or isoflurane (group I, n=58) in oxygen and nitrous oxide for maintenance of anaesthesia. Heart rate, respiratory rate, indirect arterial blood pressure, haemoglobin saturation, vaporiser settings, end-tidal carbon dioxide and anaesthetic concentration and oesophageal temperature were measured. Recovery was timed. Data were analysed using analysis of variance and non-parametric tests. Heart rate (85 to 140/minute), respiratory rate (six to 27/minute) and systolic arterial blood pressure (80 to 150 mmHg) were similar in the two groups. End-tidal carbon dioxide between 30 and 60 minutes (group S 6·4 to 6·6 and group I 5·8 to 5·9 per cent) and vaporiser settings throughout (group S 2·1 to 2·9 and group I 1·5 to 1·5 per cent) were higher in group S. There was no difference in time to head lift (18±16 minutes), sternal recumbency (28±22 minutes) or standing (48±32 minutes). No adverse events occurred. Sevoflurane appeared to be a suitable volatile anaesthetic for maintenance of routine clinical anaesthesia in dogs.
Bibliography:	http://dx.doi.org/10.1111/j.1748-5827.2008.00586.x istex:0FB2E34D9A1514FC2C597912CB6A710E21996437 ark:/67375/WNG-RHPLTV5D-6 ArticleID:JSAP586 P. M. Taylor’s current address is Taylor Monroe, Little Downham, Cambridgeshire CB6 2TY A. J. Brown’s current address is College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824‐1314, USA R. C. Bennett’s current address is Greenwood Ellis and Partners, Newmarket, Suffolk CB8 9WS S. P. J. Fancy’s current address is University of California, San Francisco, CA 94143, USA ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0022-4510 1748-5827
DOI:	10.1111/j.1748-5827.2008.00586.x