Search Results - "Fancher, R."

Metabolomic Profiling and Drug Interaction Characterization Reveal Riboflavin As a Breast Cancer Resistance Protein-Specific Endogenous Biomarker That Demonstrates Prediction of Transporter Activity In Vivo by Zhang, Yueping, Shipkova, Petia A, Warrack, Bethanne M, Nelson, David M, Wang, Linna, Huo, Runlan, Chen, Jian, Panfen, Erika, Chen, Xue-Qing, Fancher, R Marcus, Ruan, Qian, Christopher, Lisa J, Xue, Yongjun, Sinz, Michael, Shen, Hong

“…Advancement of endogenous biomarkers for drug transporters as a tool for assessing drug-drug interactions (DDIs) depends on initial identification of biomarker…”
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Evaluation of Encequidar as An Intestinal P-gp and BCRP Specific Inhibitor to Assess the Role of Intestinal P-gp and BCRP in Drug-Drug Interactions by Chu, Jessica, Panfen, Erika, Wang, Linna, Marino, Anthony, Chen, Xue-Qing, Fancher, R. Marcus, Landage, Raviraj, Patil, Omprakash, Desai, Salil Dileep, Shah, Devang, Xue, Yongjun, Sinz, Michael, Shen, Hong

“…Purpose The differences between intestinal and systemic (hepatic and renal) P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) roles in drug…”
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Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition by Gu, Xiaomei, Wang, Lifei, Gan, Jinping, Fancher, R. Marcus, Tian, Yuan, Hong, Yang, Lai, Yurong, Sinz, Michael, Shen, Hong

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Absence of OATP1B (Organic Anion-Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression by Zhang, Yueping, Chen, Cliff, Chen, Shen-Jue, Chen, Xue-Qing, Shuster, David J, Puszczalo, Pawel D, Fancher, R Marcus, Yang, Zheng, Sinz, Michael, Shen, Hong

“…Organic anion-transporting polypeptide (OATP) 1B induction is an evolving mechanism of drug disposition and interaction. However, there are contradictory…”
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Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation by Shen, Hong, Liu, Tongtong, Jiang, Hao, Titsch, Craig, Taylor, Kristin, Kandoussi, Hamza, Qiu, Xi, Chen, Cliff, Sukrutharaj, Sunil, Kuit, Kathy, Mintier, Gabe, Krishnamurthy, Prasad, Fancher, R Marcus, Zeng, Jianing, Rodrigues, A David, Marathe, Punit, Lai, Yurong

“…Organic cation transporter (OCT) 2, multidrug and toxin extrusion protein (MATE) 1, and MATE2K mediate the renal secretion of various cationic drugs and can…”
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Evaluation of rosuvastatin as an organic anion transporting polypeptide (OATP) probe substrate: in vitro transport and in vivo disposition in cynomolgus monkeys by Shen, Hong, Su, Hong, Liu, Tongtong, Yao, Ming, Mintier, Gabe, Li, Lun, Fancher, R Marcus, Iyer, Ramaswamy, Marathe, Punit, Lai, Yurong, Rodrigues, A David

“…Organic anion transporting polypeptides (OATPs) mediate hepatic drug uptake and serve as the loci of drug-drug interactions (DDIs). Consequently, there is a…”
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A convenient strategy to overcome interference in LC-MS/MS analysis: Application in a microdose absolute bioavailability study by Yuan, Long, Huang, Christine, Liu-Kreyche, Peggy, Voronin, Kimberly, Fancher, R. Marcus, Allentoff, Alban, Zheng, Naiyu, Iyer, Ramaswamy, Zhu, Li, Pillutla, Renuka, Ji, Qin C.

“…•A convenient and cost-effective strategy to overcome interference in LC–MS analysis.•This strategy minimizes the number of stable isotope labels used for…”
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Increasing the Reuse of Protein Non-Naïve Nonhuman Primates in Pharmaceutical Drug Discovery and Development: An Overview and Industry Position on the Challenges and Benefits by Mattis, Charles, Bratcher, Natalie, Burns, Monika, Carosino, Christopher, de Zafra, Christina, Fancher, R. Marcus, Georgi, Katrin, Graff, Candace, Hukkanen, Renee R., Johnson, Colena, Lao, Yanbin, Lange, Amber, Lee, Donna, Lepherd, Michelle, Maguire, Sean, Malisauskas, Mantas, Manuel, Melinda, Miranda, Sonia, Reed, Lori, Santos, Rosemary, Sayers, Brian, Shaw, David, Shuster, David

“…The IQ Consortium NHP Reuse Working Group (WG) comprises members from 15 pharmaceutical and biotechnology companies. In 2020, the WG developed and distributed…”
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Investigation of the “true” extraction recovery of analytes from multiple types of tissues and its impact on tissue bioanalysis using two model compounds by Yuan, Long, Ma, Li, Dillon, Lisa, Fancher, R. Marcus, Sun, Huadong, Zhu, Mingshe, Lehman-McKeeman, Lois, Aubry, Anne-Françoise, Ji, Qin C.

“…LC-MS/MS has been widely applied to the quantitative analysis of tissue samples. However, one key remaining issue is that the extraction recovery of analyte…”
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Development of a canine model to enable the preclinical assessment of pH-dependent absorption of test compounds by Fancher, R Marcus, Zhang, Hongjian, Sleczka, Bogdan, Derbin, George, Rockar, Richard, Marathe, Punit

“…A preclinical canine model capable of predicting a compound's potential for pH-dependent absorption in humans was developed. This involved the surgical…”
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Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement by Li, Wenying, Zhao, Weiping, Liu, Xiaohong, Huang, Xiaohua, Lopez, Omar D, Leet, John E, Fancher, R Marcus, Nguyen, Van, Goodrich, Jason, Easter, John, Hong, Yang, Caceres-Cortes, Janet, Chang, Shu Y, Ma, Li, Belema, Makonen, Hamann, Lawrence G, Gao, Min, Zhu, Mingshe, Shu, Yue-Zhong, Humphreys, W Griffith, Johnson, Benjamin M

“…Daclatasvir is a first-in-class, potent, and selective inhibitor of the hepatitis C virus nonstructural protein 5A replication complex. In support of…”
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Utility of in situ sodium alginate/karaya gum gels to facilitate gastric retention in rodents by Foster, Kimberly A., Morgen, Mike, Murri, Brice, Yates, Ian, Fancher, R. Marcus, Ehrmann, Jon, Gudmundsson, Olafur S., Hageman, Michael J.

“…Barium sulfate suspension (left) and in situ gel containing barium sulfate (right) 1h post-dose. Target validation or demonstration of efficacy requires…”
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Application of ultrasound‐guided cholecystocentesis to the evaluation of the metabolite profiling in bile of dogs and cynomolgus monkeys by Dierks, Elizabeth A., Luk, Chiuwa E., Cai, Hong, MacGuire, Jamus, Fox, Maxine, Smalley, James, Fancher, R. Marc, Janovitz, Evan, Foster, Kimberly, Sun, Qin

“…In this study, we describe a novel approach for collecting bile from dogs and cynomolgus monkeys for metabolite profiling, ultrasound‐guided cholecystocentesis…”
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A liquid chromatography tandem mass spectrometry method for the quantification of indocyanine green in dog plasma and bile by Chen, Cliff Y., Fancher, R. Marc, Ruan, Qian, Marathe, Punit, Rodrigues, A. David, Yang, Zheng

“…A sensitive and specific liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) method was developed and validated for the determination of…”
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Palm oil wastewater methane emissions and bioenergy potential by Taylor, Philip. G., Bilinski, Teresa M., Fancher, Hana R. F., Cleveland, Cory C., Nemergut, Diana R., Weintraub, Samantha R., Wieder, William R., Townsend, Alan R.

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Mechanism-based inhibition of human cytochrome P4503A4 by domperidone by Chang, S.-Y., Fancher, R.M., Zhang, H., Gan, J.

“…Domperidone was evaluated in direct and time-dependent cytochrome P450 (CYP) 3A inhibition assays in human liver microsomes with midazolam and testosterone as…”
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Grain growth and mechanical properties in bulk polycrystalline silicon by FANCHER, R. W, WATKINS, C. M, NORTON, M. G, BAHR, D. F, OSBORNE, E. W

“…The grain structure of bulk polycrystalline silicon has been examined as a function of annealing temperatures and times between 1000 and 1400°C and 6 to 24…”
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Metabolism of α-phosphonosulfonate squalene synthase inhibitors. I. Disposition of a farnesylethyl α-phosphonosulfonate and ester prodrugs in rats by LAN, S.-J, HSIEH, D. C, HILLYER, J. W, FANCHER, R. M, RINEHART, K. J, WARRACK, B. M, WHITE, R. E

“…The disposition of I [(E,E)-6,10,14-trimethyl-1-phosphono-5,9, 13-pentadecatriene-1-sulfonic acid] and its mono- (II), di- (III), and triester (IV) prodrugs in…”
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Snapshots of Freud in America, 1899-1999 by Fancher, Raymond E

“…In 1899, Sigmund Freud was virtually unknown in America, and his new book, The Interpretation of Dreams, went unreviewed. A century later, his life and work…”
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Dependence of the kinetic energy absorption capacity of bistable mechanical metamaterials on impactor mass and velocity by Fancher, R., Frankel, I., Chin, K.C.H., Abi Ghanem, M., MacNider, B., Shannahan, L.S., Berry, J.F., Fermen-Coker, M., Boydston, A.J., Boechler, N.

“…Using an alternative mechanism to dissipation or scattering, bistable structures and mechanical metamaterials have shown promise for mitigating the detrimental…”
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