Search Results - "Fan Chung, K."

Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI) by Bel, Elisabeth H, Sousa, Ana, Fleming, Louise, Bush, Andrew, Chung, K Fan, Versnel, Jennifer, Wagener, Ariane H, Wagers, Scott S, Sterk, Peter J, Compton, Chris H

“…Patients with severe refractory asthma pose a major healthcare problem. Over the last decade it has become increasingly clear that, for the development of new…”
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New targets for drug development in asthma by Adcock, Ian M, Prof, Caramori, Gaetano, MD, Chung, K Fan, Prof

“…Summary Asthma is a chronic inflammatory disease that affects about 300 million people worldwide, a total that is expected to rise to about 400 million over…”
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Asthma Is More Severe in Older Adults by Zein, Joe G, Dweik, Raed A, Comhair, Suzy A, Bleecker, Eugene R, Moore, Wendy C, Peters, Stephen P, Busse, William W, Jarjour, Nizar N, Calhoun, William J, Castro, Mario, Chung, K Fan, Fitzpatrick, Anne, Israel, Elliot, Teague, W Gerald, Wenzel, Sally E, Love, Thomas E, Gaston, Benjamin M, Erzurum, Serpil C

“…Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is…”
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Increased Expression of Transient Receptor Potential Vanilloid-1 in Airway Nerves of Chronic Cough by Groneberg, David A, Niimi, Akio, Dinh, Q. Thai, Cosio, Borja, Hew, Mark, Fischer, Axel, Chung, K. Fan

“…Transient receptor potential vanniloid-1 (TRPV-1) mediates the cough response induced by the pepper extract capsaicin and is expressed in sensory nerves that…”
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Effects of Treatment with Anti-immunoglobulin E Antibody Omalizumab on Airway Inflammation in Allergic Asthma by Djukanovic, Ratko, Wilson, Susan J, Kraft, Monica, Jarjour, Nizar N, Steel, Mark, Chung, K. Fan, Bao, Weibin, Fowler-Taylor, Angel, Matthews, John, Busse, William W, Holgate, Stephen T, Fahy, John V

“…IgE plays an important role in allergic asthma. We hypothesized that reducing IgE in the airway mucosa would reduce airway inflammation. Forty-five patients…”
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Histone Acetylase and Deacetylase Activity in Alveolar Macrophages and Blood Mononocytes in Asthma by Cosio, Borja G, Mann, Buphinder, Ito, Kazuhiro, Jazrawi, Elen, Barnes, Peter J, Chung, K. Fan, Adcock, Ian M

“…Histone acetylation status is a key factor in the regulation of inflammatory gene transcription. We investigated the activity of histone acetylases (HAT) and…”
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Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response by Leckie, Margaret J, Brinke, Anneke ten, Khan, Jamey, Diamant, Zuzana, O'Connor, Brian J, Walls, Christine M, Mathur, Ashwini K, Cowley, Hugh C, Chung, K Fan, Djukanovic, Ratko, Hansel, Trevor T, Holgate, Stephen T, Sterk, Peter J, Barnes, Peter J

“…Interleukin-5 (IL-5) is essential for the formation of eosinophils, which are thought to have a major role in the pathogenesis of asthma and other allergic…”
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Expression and Activity of Histone Deacetylases in Human Asthmatic Airways by Ito, Kazuhiro, Caramori, Gaetano, Lim, Sam, Oates, Tim, Chung, K. Fan, Barnes, Peter J, Adcock, Ian M

“…Asthma is a chronic inflammatory disease that is characterized by increased expression of multiple inflammatory genes. Chromatin modification plays a critical…”
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A Molecular Mechanism of Action of Theophylline: Induction of Histone Deacetylase Activity to Decrease Inflammatory Gene Expression by Ito, Kazuhiro, Lim, Sam, Caramori, Gaetano, Cosio, Borja, Chung, K. Fan, Adcock, Ian M., Barnes, Peter J.

“…The molecular mechanism for the anti-inflammatory action of theophylline is currently unknown, but low-dose theophylline is an effective add-on therapy to…”
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Diminished sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma by Mahn, Katharina, Hirst, Stuart J, Ying, Sun, Holt, Mark R, Lavender, Paul, Ojo, Oluwaseun O, Siew, Leonard, Simcock, David E, McVicker, Clare G, Kanabar, Varsha, Snetkov, Vladimir A, O'Connor, Brian J, Karner, Charlotta, Cousins, David J, Macedo, Patricia, Chung, K. Fan, Corrigan, Christopher J, Ward, Jeremy P.T, Lee, Tak H

“…Phenotypic modulation of airway smooth muscle (ASM) is an important feature of airway remodeling in asthma that is characterized by enhanced proliferation and…”
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Models of chronic obstructive pulmonary disease by Groneberg, David A, Chung, K Fan

“…Chronic obstructive pulmonary disease (COPD) is a major global health problem and is predicted to become the third most common cause of death by 2020. Apart…”
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A Polymorphism Affecting MYB Binding within the Promoter of the PDCD4 Gene is Associated with Severe Asthma in Children by Binia, Aristea, Van Stiphout, Nicole, Liang, Liming, Michel, Sven, Bhavsar, Pankaj K., Fan Chung, K., Brightling, Chris E., Barnes, Peter J., Kabesch, Michael, Bush, Andrew, Cookson, William O.C., Moffatt, Miriam F.

“…ABSTRACT A previous genome‐wide association study in asthma revealed putative associations that merit further investigation. In this study, the genome‐wide…”
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Chromosome 17q21 SNP and severe asthma by Binia, Aristea, Khorasani, Nadia, Bhavsar, Pankaj K, Adcock, Ian, Brightling, Chris E, Chung, K Fan, Cookson, William O C, Moffatt, Miriam F

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Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations by CARAMORI, G, ROMAGNOLI, M, FABBRI, L. M, PAPI, A, CASOLARI, P, BELLETTATO, C, CASONI, G, BOSCHETTO, P, CHUNG, K. Fan, BARNES, P. J, ADCOCK, I. M, CIACCIA, A

“…Exacerbations represent an important feature of the clinical manifestation and natural history of chronic obstructive pulmonary disease (COPD). Nuclear…”
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Role of c‐jun N‐terminal kinase in the induced release of GM‐CSF, RANTES and IL‐8 from human airway smooth muscle cells by Oltmanns, Ute, Issa, Razao, Sukkar, Maria B, John, Matthias, Chung, K Fan

“…Human airway smooth muscle cells (HASMC) contribute to airway inflammation in asthma by virtue of their capacity to produce several inflammatory mediators…”
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IL-4 and IL-13 Form a Negative Feedback Circuit with Surfactant Protein-D in the Allergic Airway Response by Haczku, Angela, Cao, Yang, Vass, Geza, Kierstein, Sonja, Nath, Puneeta, Atochina-Vasserman, Elena N, Scanlon, Seth T, Li, Lily, Griswold, Don E, Chung, K. Fan, Poulain, Francis R, Hawgood, Samuel, Beers, Michael F, Crouch, Erika C

“…The innate immune molecule surfactant protein-D (SP-D) plays an important regulatory role in the allergic airway response. In this study, we demonstrate that…”
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Molecular Mechanisms of Pulmonary Peptidomimetic Drug and Peptide Transport by Groneberg, David A, Fischer, Axel, Chung, K. Fan, Daniel, Hannelore

“…The aerosolic administration of peptidomimetic drugs could play a major role in the future treatment of various pulmonary and systemic diseases, because…”
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Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers : Regulation by interleukin-10 by LIM, Sam, ROCHE, Nicolas, OLIVER, Brian G, MATTOS, Waldo, BARNES, Peter J, FAN CHUNG, K

“…An imbalance between proteases and antiproteases may play a role in emphysema, which is characterized by increased degradation of extracellular matrix, and in…”
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IL‐17‐induced cytokine release in human bronchial epithelial cells in vitro: role of mitogen‐activated protein (MAP) kinases by Laan, Martti, Lötvall, Jan, Chung, K Fan, Lindén, Anders

“…Recent data indicate that interleukin (IL)‐17 may contribute to neutrophilic airway inflammation by inducing the release of neutrophil‐mobilizing cytokines…”
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Interleukin-5 Induces CD34+ Eosinophil Progenitor Mobilization and Eosinophil CCR3 Expression in Asthma by STIRLING, ROBERT G, VAN RENSEN, ELIZABETH L. J, BARNES, PETER J, FAN CHUNG, K

“…Asthma is characterized by the accumulation of activated T cells and eosinophils within the airway. Eosinophils derive from CD34(+) bone marrow progenitor…”
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