Search Results - "Fan, Teresa W M"

Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation by Sellers, Katherine, Fox, Matthew P, Bousamra, 2nd, Michael, Slone, Stephen P, Higashi, Richard M, Miller, Donald M, Wang, Yali, Yan, Jun, Yuneva, Mariia O, Deshpande, Rahul, Lane, Andrew N, Fan, Teresa W-M

“…Anabolic biosynthesis requires precursors supplied by the Krebs cycle, which in turn requires anaplerosis to replenish precursor intermediates. The major…”
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Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC by Liu, Wei, Le, Anne, Hancock, Chad, Lane, Andrew N., Dang, Chi V., Fan, Teresa W.-M., Phang, James M.

“…In addition to glycolysis, the oncogenic transcription factor c-MYC (MYC) stimulates glutamine catabolism to fuel growth and proliferation of cancer cells…”
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Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype by Liu, Min, Luo, Fengling, Ding, Chuanlin, Albeituni, Sabrin, Hu, Xiaoling, Ma, Yunfeng, Cai, Yihua, McNally, Lacey, Sanders, Mary Ann, Jain, Dharamvir, Kloecker, Goetz, Bousamra, 2nd, Michael, Zhang, Huang-ge, Higashi, Richard M, Lane, Andrew N, Fan, Teresa W-M, Yan, Jun

“…Tumor-associated macrophages (TAM) with an alternatively activated phenotype have been linked to tumor-elicited inflammation, immunosuppression, and resistance…”
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Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM) by Bruntz, Ronald C., Lane, Andrew N., Higashi, Richard M., Fan, Teresa W.-M.

“…Metabolic reprogramming is a hallmark of cancer. The changes in metabolism are adaptive to permit proliferation, survival, and eventually metastasis in a harsh…”
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NMR-based isotope editing, chemoselection and isotopomer distribution analysis in stable isotope resolved metabolomics by Lin, Penghui, W-M. Fan, Teresa, Lane, Andrew N.

“…•We review recent developments in NMR-based stable isotope tracing.•Isotope editing is a powerful NMR tool for selecting and identifying…”
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An obligatory role for neurotensin in high-fat-diet-induced obesity by Li, Jing, Song, Jun, Zaytseva, Yekaterina Y., Liu, Yajuan, Rychahou, Piotr, Jiang, Kai, Starr, Marlene E., Kim, Ji Tae, Harris, Jennifer W., Yiannikouris, Frederique B., Katz, Wendy S., Nilsson, Peter M., Orho-Melander, Marju, Chen, Jing, Zhu, Haining, Fahrenholz, Timothy, Higashi, Richard M., Gao, Tianyan, Morris, Andrew J., Cassis, Lisa A., Fan, Teresa W. -M., Weiss, Heidi L., Dobner, Paul R., Melander, Olle, Jia, Jianhang, Evers, B. Mark

“…Neurotensin, a peptide expressed in the enteroendocrine cells of the small intestine that is released upon fat ingestion, is shown to increase fatty acid…”
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The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer by Wen, Yang-An, Xiong, Xiaopeng, Scott, Timothy, Li, Austin T., Wang, Chi, Weiss, Heidi L., Tan, Li, Bradford, Emily, Fan, Teresa W. M., Chandel, Navdeep S., Barrett, Terrence A., Gao, Tianyan

“…Cancer cells are known to upregulate aerobic glycolysis to promote growth, proliferation, and survival. However, the role of mitochondrial respiration in…”
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Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing by Sun, Ramon C., Fan, Teresa W.-M., Deng, Pan, Higashi, Richard M., Lane, Andrew N., Le, Anh-Thu, Scott, Timothy L., Sun, Qiushi, Warmoes, Marc O., Yang, Ye

“…Delivering isotopic tracers for metabolic studies in rodents without overt stress is challenging. Current methods achieve low label enrichment in proteins and…”
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Stable isotope-resolved metabolomics and applications for drug development by Fan, Teresa W-M, Lorkiewicz, Pawel K, Sellers, Katherine, Moseley, Hunter N B, Higashi, Richard M, Lane, Andrew N

“…Advances in analytical methodologies, principally nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS), during the last decade have made…”
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Bayesian kinetic modeling for tracer-based metabolomic data by Zhang, Xu, Su, Ya, Lane, Andrew N, Stromberg, Arnold J, Fan, Teresa W M, Wang, Chi

“…Stable Isotope Resolved Metabolomics (SIRM) is a new biological approach that uses stable isotope tracers such as uniformly [Formula: see text]-enriched…”
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Correction: Bayesian kinetic modeling for tracer-based metabolomic data by Zhang, Xu, Su, Ya, Lane, Andrew N, Stromberg, Arnold J, Fan, Teresa W M, Wang, Chi

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Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer by Bruntz, Ronald C., Belshoff, Alex C., Zhang, Yan, Macedo, Jessica K. A., Higashi, Richard M., Lane, Andrew N., Fan, Teresa W.‐M.

“…Large clinical trials and model systems studies suggest that the chemical form of selenium dictates chemopreventive and chemotherapeutic efficacy. Selenite…”
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Regulation of mammalian nucleotide metabolism and biosynthesis by Lane, Andrew N, Fan, Teresa W-M

“…Nucleotides are required for a wide variety of biological processes and are constantly synthesized de novo in all cells. When cells proliferate, increased…”
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Knockdown of Malic Enzyme 2 Suppresses Lung Tumor Growth, Induces Differentiation and Impacts PI3K/AKT Signaling by Ren, Jian-Guo, Seth, Pankaj, Clish, Clary B., Lorkiewicz, Pawel K., Higashi, Richard M., Lane, Andrew N., Fan, Teresa W.-M., Sukhatme, Vikas P.

“…Mitochondrial malic enzyme 2 (ME2) catalyzes the oxidative decarboxylation of malate to yield CO 2 and pyruvate, with concomitant reduction of dinucleotide…”
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Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma by Yang, Youfeng, Lane, Andrew N, Ricketts, Christopher J, Sourbier, Carole, Wei, Ming-Hui, Shuch, Brian, Pike, Lisa, Wu, Min, Rouault, Tracey A, Boros, Laszlo G, Fan, Teresa W-M, Linehan, W Marston

“…Fumarate hydratase (FH)-deficient kidney cancer undergoes metabolic remodeling, with changes in mitochondrial respiration, glucose, and glutamine metabolism…”
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Preclinical models for interrogating drug action in human cancers using Stable Isotope Resolved Metabolomics (SIRM) by Lane, Andrew N., Higashi, Richard M., Fan, Teresa W.-M.

“…Objectives In this review we compare the advantages and disadvantages of different model biological systems for determining the metabolic functions of cells in…”
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Photoinducible Oncometabolite Detection by Kulkarni, Rhushikesh A., Briney, Chloe A., Crooks, Daniel R., Bergholtz, Sarah E., Mushti, Chandrasekhar, Lockett, Stephen J., Lane, Andrew N., Fan, Teresa W.‐M., Swenson, Rolf E., Marston Linehan, W., Meier, Jordan L.

“…Dysregulated metabolism can fuel cancer by altering the production of bioenergetic building blocks and directly stimulating oncogenic gene‐expression programs…”
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Isotopomer analysis of lipid biosynthesis by high resolution mass spectrometry and NMR by Lane, Andrew N., Fan, Teresa W.-M., Xie, Zhengzhi, Moseley, Hunter N.B., Higashi, Richard M.

“…We have coupled 2D-NMR and infusion FT-ICR-MS with computer-assisted assignment to profile 13C-isotopologues of glycerophospholipids (GPL) directly in crude…”
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Role in Tumor Growth of a Glycogen Debranching Enzyme Lost in Glycogen Storage Disease by GUIN, Sunny, POLLARD, Courtney, GUPTA, Sounak, HANSEL, Donna, HELLERSTEIN, Marc, LORKIEWICZ, Pawel, LANE, Andrew N, FAN, Teresa W.-M, THEODORESCU, Dan, YUANBIN RU, LEW, Carolyn Ritterson, DUEX, Jason E, DANCIK, Garrett, OWENS, Charles, SPENCER, Andrea, KNIGHT, Scott, HOLEMON, Heather

“…Bladder cancer is the most common malignancy of the urinary system, yet our molecular understanding of this disease is incomplete, hampering therapeutic…”
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Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer by Fan, Teresa W-M, Winnike, Jason, Al-Attar, Ahmad, Belshoff, Alexander C, Lorkiewicz, Pawel K, Tan, Jin Lian, Wu, Min, Higashi, Richard M, Lane, Andrew N

“…Past chemopreventive human trials on dietary selenium supplements produced controversial outcomes. They largely employed selenomethionine (SeM)-based diets…”
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