Search Results - "Fan, Qi‐Wen"

Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies by An, Zhenyi, Aksoy, Ozlem, Zheng, Tina, Fan, Qi-Wen, Weiss, William A.

“…Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play…”
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Health Effects of Household Solid Fuel Use: Findings from 11 Countries within the Prospective Urban and Rural Epidemiology Study by Hystad, Perry, Duong, MyLinh, Brauer, Michael, Larkin, Andrew, Arku, Raphael, Kurmi, Om P, Fan, Wen Qi, Avezum, Alvaro, Azam, Igbal, Chifamba, Jephat, Dans, Antonio, du Plessis, Johan L, Gupta, Rajeev, Kumar, Rajesh, Lanas, Fernando, Liu, Zhiguang, Lu, Yin, Lopez-Jaramillo, Patricio, Mony, Prem, Mohan, Viswanathan, Mohan, Deepa, Nair, Sanjeev, Puoane, Thandi, Rahman, Omar, Lap, Ah Tse, Wang, Yanga, Wei, Li, Yeates, Karen, Rangarajan, Sumathy, Teo, Koon, Yusuf, Salim

“…Household air pollution (HAP) from solid fuel use for cooking affects 2.5 billion individuals globally and may contribute substantially to disease burden…”
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Inhibiting 4EBP1 in Glioblastoma by Fan, Qi Wen, Nicolaides, Theodore P, Weiss, William A

“…Glioblastoma is the most common and aggressive adult brain cancer. Tumors show frequent dysregulation of the PI3K-mTOR pathway. Although a number of small…”
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EGFR Phosphorylates Tumor-Derived EGFRvIII Driving STAT3/5 and Progression in Glioblastoma by Fan, Qi-Wen, Cheng, Christine K., Gustafson, W. Clay, Charron, Elizabeth, Zipper, Petra, Wong, Robyn A., Chen, Justin, Lau, Jasmine, Knobbe-Thomsen, Christiane, Weller, Michael, Jura, Natalia, Reifenberger, Guido, Shokat, Kevan M., Weiss, William A.

“…EGFRvIII, a frequently occurring mutation in primary glioblastoma, results in a protein product that cannot bind ligand, but signals constitutively. Deducing…”
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Akt and autophagy cooperate to promote survival of drug-resistant glioma by Fan, Qi-Wen, Cheng, Christine, Hackett, Chris, Feldman, Morri, Houseman, Benjamin T, Nicolaides, Theodore, Haas-Kogan, Daphne, James, C David, Oakes, Scott A, Debnath, Jayanta, Shokat, Kevan M, Weiss, William A

“…Although the phosphatidylinositol 3-kinase to Akt to mammalian target of rapamycin (PI3K-Akt-mTOR) pathway promotes survival signaling, inhibitors of PI3K and…”
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PI3K Signaling in Glioma-Animal Models and Therapeutic Challenges by Cheng, Christine K., Fan, Qi-Wen, Weiss, William A.

“…The PI3 kinase (PI3K) family plays a complex role in cell biology and metabolism. Signaling through the PI3Ks is frequently activated in many human cancers,…”
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Structure-guided development of affinity probes for tyrosine kinases using chemical genetics by Kung, Charles, Blair, Jimmy A, Rode, Haridas, Weiss, William A, Shokat, Kevan M, Fan, Qi-Wen, Eck, Michael J, Yun, Cai-Hong, Zhang, Chao, Rauh, Daniel

“…As key components in nearly every signal transduction pathway, protein kinases are attractive targets for the regulation of cellular signaling by…”
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Autophagy and Akt promote survival in glioma by Fan, Qi-Wen, Weiss, William A.

“…Signaling through phosphatidylinositol 3-kinase (PtdIns3K)-Akt-mTOR is frequently activated in cancers including glioblastoma multiforme (GBM), where this…”
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EGFR signals to mTOR through PKC and independently of Akt in glioma by Fan, Qi-Wen, Cheng, Christine, Knight, Zachary A, Haas-Kogan, Daphne, Stokoe, David, James, C David, McCormick, Frank, Shokat, Kevan M, Weiss, William A

“…Amplification of the gene encoding the epidermal growth factor (EGF) receptor (EGFR) occurs commonly in glioblastoma, leading to activation of downstream…”
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Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity by Yu, Wei, Shewan, Annette M, Brakeman, Paul, Eastburn, Dennis J, Datta, Anirban, Bryant, David M, Fan, Qi-Wen, Weiss, William A, Zegers, Mirjam M P, Mostov, Keith E

“…In multicellular epithelial tissues, the orientation of polarity of each cell must be coordinated. Previously, we reported that for Madin–Darby canine kidney…”
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Increased BnaMFT-transcript level is associated with secondary dormancy in oilseed rape (Brassica napus L.) by LIU, Lei, FAN, Wen-qi, LIU, Fu-xia, YI, Xin, TANG, Tang, ZHOU, Ying, TANG, Zi-wei, CHEN, Gui-min, ZHAO, Xiang-xiang

“…Brassica napus cultivars have little or no primary dormancy; however, they are prone to secondary dormancy induction. Secondary dormant seeds can produce…”
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Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers by Barkovich, Krister J, Hariono, Sujatmi, Garske, Adam L, Zhang, Jie, Blair, Jimmy A, Fan, Qi-Wen, Shokat, Kevan M, Nicolaides, Theodore, Weiss, William A

“…Although mutational activation of the epidermal growth factor receptor (EGFR) features prominently in glioma and non-small cell lung cancer (NSCLC), inhibitors…”
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Apolipoprotein E Exhibits Isoform‐Specific Promotion of Lipid Efflux from Astrocytes and Neurons in Culture by Michikawa, Makoto, Fan, Qi‐Wen, Isobe, Ichiro, Yanagisawa, Katsuhiko

“…: Many studies have shown that apolipoprotein E (apoE) plays important roles in maintaining intracellular lipid homeostasis in nonneuronal cells. However,…”
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Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma by Cheng, Christine K., Gustafson, W. Clay, Charron, Elizabeth, Houseman, Benjamin T., Zunder, Eli, Goga, Andrei, Gray, Nathanael S., Pollok, Brian, Oakes, Scott A., James, C. David, Shokat, Kevan M., Weiss, William A., Fan, Qi-Wen

“…Malignant glioma, the most common primary brain tumor, is generally incurable. Although phosphatidylinositol-3-kinase (PI3K) signaling features prominently in…”
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RNA interference against a glioma-derived allele of EGFR induces blockade at G2M by FAN, Qi-Wen, WEISS, William A

“…Amplification and mutation of the epidermal growth factor receptor (EGFR) is common in astrocytoma. The most frequently occurring mutation (DeltaEGFR,…”
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Blockade of glioma proliferation through allosteric inhibition of JAK2 by He, Kunyan, Qi, Qi, Chan, Chi-Bun, Xiao, Ge, Liu, Xia, Tucker-Burden, Carol, Wang, Liya, Mao, Hui, Lu, Xiang, McDonald, Frank E, Luo, Hongbo, Fan, Qi-Wen, Weiss, William A, Sun, Shi-Yong, Brat, Daniel J, Ye, Keqiang

“…The gene that encodes the epidermal growth factor receptor (EGFR) is frequently overexpressed or mutated in human cancers, including glioblastoma. However, the…”
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Cholesterol‐dependent modulation of tau phosphorylation in cultured neurons by Fan, Qi‐Wen, Yu, Wei, Senda, Takao, Yanagisawa, Katsuhiko, Michikawa, Makoto

“…One of the hallmarks of Alzheimer's disease (AD) is the abnormal state of tau. It is both highly phosphorylated and aggregated into paired helical filaments…”
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Cholesterol‐dependent modulation of dendrite outgrowth 
and microtubule stability in cultured neurons by Fan, Qi‐Wen, Yu, Wei, Gong, Jian‐Sheng, Zou, Kun, Sawamura, Naoya, Senda, Takao, Yanagisawa, Katsuhiko, Michikawa, Makoto

“…Microtubule‐associated protein 2 (MAP2) is a neuron‐specific cytoskeletal protein enriched in dendrites and cell bodies. MAP2 regulates microtubule stability…”
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Isoform Specific Inhibitors of PI3 Kinase in Glioma by Fan, Qi-Wen, Weiss, William A.

“…The PI3 kinase pathway is among the most frequently activated signaling pathways in human cancer and represents an attractive target for small molecule…”
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A Null Mutation in Basigin, an Immunoglobulin Superfamily Member, Indicates Its Important Roles in Peri-implantation Development and Spermatogenesis by Igakura, Tadahiko, Kadomatsu, Kenji, Kaname, Tadashi, Muramatsu, Hisako, Fan, Qi-Wen, Miyauchi, Teruo, Toyama, Yoshiro, Kuno, Naohiko, Yuasa, Shigeki, Takahashi, Masahide, Senda, Takao, Taguchi, Osamu, Yamamura, Ken-ichi, Arimura, Kimiyoshi, Muramatsu, Takashi

“…Basigin is a highly glycosylated transmembrane protein with two immunoglobulin-like domains. We generated mutant mice lacking the basigin gene (Bsg) by gene…”
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