Search Results - "Fan, Peter"

Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human by Basit, Abdul, Neradugomma, Naveen K, Wolford, Christopher, Fan, Peter W, Murray, Bernard, Takahashi, Ryan H, Khojasteh, S. Cyrus, Smith, Bill J, Heyward, Scott, Totah, Rheem A, Kelly, Edward J, Prasad, Bhagwat

“…The availability of assays that predict the contribution of cytochrome P450 (CYP) metabolism allows for the design of new chemical entities (NCEs) with minimal…”
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Investigation of Drug Delivery in Rats via Subcutaneous Injection: Case Study of Pharmacokinetic Modeling of Suspension Formulations by Chiang, Po-Chang, Nagapudi, Karthik, Fan, Peter W, Liu, Jia

“…With the rising cost of drug research, "do more with less" has become a new emphasis in the pharmaceutical industry. Consequently, the early analysis of…”
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Regional proteomic quantification of clinically relevant non-cytochrome P450 enzymes along the human small intestine by Zhang, Haeyoung, Wolford, Chris, Basit, Abdul, Li, Albert P, Fan, Peter W, Takahashi, Ryan H, Khojasteh, S Cyrus, Smith, Bill J, Murray, Bernard P, Thummel, Kenneth, Prasad, Bhagwat

“…Current challenges in accurately predicting intestinal metabolism arise from the complex nature of the intestine, leading to limited applicability of available…”
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Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species by Basit, Abdul, Fan, Peter W, Khojasteh, S Cyrus, Murray, Bernard P, Smith, Bill J, Heyward, Scott, Prasad, Bhagwat

“…The use of animal pharmacokinetic models as surrogates for humans relies on the assumption that the drug disposition mechanisms are similar between preclinical…”
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Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase by Fan, Peter W, Zhang, Donglu, Halladay, Jason S, Driscoll, James P, Khojasteh, S Cyrus

“…The significant roles that cytochrome P450 (P450) and UDP-glucuronosyl transferase (UGT) enzymes play in drug discovery cannot be ignored, and these enzyme…”
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Carboxylesterase catalyzed 18O-labeling of carboxylic acid and its potential application in LC-MS/MS based quantification of drug metabolites by Yu, Zaikuan J., Roesner, Joseph M., Lutz, Ryan, Liang, Yuexia, Baker, James, Smith, Dustin M., Fan, Peter W.

“…LC-MS quantification of drug metabolites is sometimes impeded by the availability of internal standards that often requires customized synthesis and/or…”
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Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design by Crawford, James J., Feng, Jianwen, Brightbill, Hans D., Johnson, Adam R., Wright, Matthew, Kolesnikov, Aleksandr, Lee, Wendy, Castanedo, Georgette M., Do, Steven, Blaquiere, Nicole, Staben, Steven T., Chiang, Po-Chang, Fan, Peter W., Baumgardner, Matt, Wong, Susan, Godemann, Robert, Grabbe, Alice, Wiegel, Catharina, Sujatha-Bhaskar, Swathi, Hymowitz, Sarah G., Liau, Nicholas, Hsu, Peter L., McEwan, Paul A., Ismaili, Moulay Hicham Alaoui, Landry, Matthew L.

“…[Display omitted] Inhibition of NF-κB inducing kinase (NIK) has been pursued as a promising therapeutic target for autoimmune disorders due to its highly…”
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Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors by Crawford, James J, Lee, Wendy, Aliagas, Ignacio, Mathieu, Simon, Hoeflich, Klaus P, Zhou, Wei, Wang, Weiru, Rouge, Lionel, Murray, Lesley, La, Hank, Liu, Ning, Fan, Peter W, Cheong, Jonathan, Heise, Christopher E, Ramaswamy, Sreemathy, Mintzer, Robert, Liu, Yanzhou, Chao, Qi, Rudolph, Joachim

“…The p21-activated kinases (PAKs) play important roles in cytoskeletal organization, cellular morphogenesis, and survival and have generated significant…”
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Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology by Lu, Min, Zhang, Hongjun, Li, Derun, Childers, Matthew, Pu, Qinglin, Palte, Rachel L, Gathiaka, Symon, Lyons, Thomas W, Palani, Anandan, Fan, Peter W, Spacciapoli, Peter, Miller, J. Richard, Cho, Hyelim, Cheng, Mangeng, Chakravarthy, Kalyan, O’Neil, Jennifer, Eangoor, Padmanabhan, Beard, Adam, Kim, Hai-Young, Saurí, Josep, Gunaydin, Hakan, Sloman, David L, Siliphaivanh, Phieng, Cumming, Jared, Fischer, Christian

“…Recent data suggest that the inhibition of arginase (ARG) has therapeutic potential for the treatment of a number of indications ranging from pulmonary and…”
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Insights from the reanalysis of high-throughput chemical genomics data for Escherichia coli K-12 by Wu, Peter I-Fan, Ross, Curtis, Siegele, Deborah A, Hu, James C

“…Despite the demonstrated success of genome-wide genetic screens and chemical genomics studies at predicting functions for genes of unknown function or…”
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Ileocolonic-Targeted JAK Inhibitor: A Safer and More Effective Treatment for Inflammatory Bowel Disease by Yadav, Vipul, House, Aileen, Matiz, Silvia, McCoubrey, Laura E, Bettano, Kimberly A, Bhave, Leena, Wang, Meiyao, Fan, Peter, Zhou, Siqun, Woodhouse, Janice D, Poimenidou, Eirini, Dou, Liu, Basit, Abdul W, Moy, Lily Y, Saklatvala, Robert, Hegde, Laxminarayan G, Yu, Hongshi

“…Janus kinase (JAK) inhibitors, such as tofacitinib (Xeljanz) and filgotinib (Jyseleca), have been approved for treatment of ulcerative colitis with several…”
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Characterization of Raloxifene Glucuronidation in Vitro: Contribution of Intestinal Metabolism to Presystemic Clearance by KEMP, Daniel C, FAN, Peter W, STEVENS, Jeffrey C

“…Raloxifene, a selective estrogen receptor modulator used for the treatment of osteoporosis, undergoes extensive conjugation to the 6-β- and…”
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Introduction and expression of PIK3CA E545K in a papillary thyroid cancer BRAF V600E cell line leads to a dedifferentiated aggressive phenotype by Pinto, Nicole, Ruicci, Kara M., Khan, Mohammed Imran, Shaikh, Mushfiq Hassan, Zeng, Yu Fan Peter, Yoo, John, Fung, Kevin, MacNeil, S. Danielle, Mendez, Adrian, Mymryk, Joe S., Barrett, John W., Boutros, Paul C., Nichols, Anthony C.

“…Anaplastic thyroid cancer (ATC) is a rare, aggressive form of undifferentiated thyroid cancer, which exhibits rapid progression and is almost universally…”
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A10 - Characterization of differential tissue abundance of major non-cyp enzymes in human by Neradugomma, Naveen, Basit, Abdul, Takahashi, Ryan, Fan, Peter, Smith, Bill, Murray, Bernard, Heyward, Scott, Wolford, Chris, Kelly, Edward J., Prasad, Bhagwat

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NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus by Brightbill, Hans D., Suto, Eric, Blaquiere, Nicole, Ramamoorthi, Nandhini, Sujatha-Bhaskar, Swathi, Gogol, Emily B., Castanedo, Georgette M., Jackson, Benjamin T., Kwon, Youngsu C., Haller, Susan, Lesch, Justin, Bents, Karin, Everett, Christine, Kohli, Pawan Bir, Linge, Sandra, Christian, Laura, Barrett, Kathy, Jaochico, Allan, Berezhkovskiy, Leonid M., Fan, Peter W., Modrusan, Zora, Veliz, Kelli, Townsend, Michael J., DeVoss, Jason, Johnson, Adam R., Godemann, Robert, Lee, Wyne P., Austin, Cary D., McKenzie, Brent S., Hackney, Jason A., Crawford, James J., Staben, Steven T., Alaoui Ismaili, Moulay H., Wu, Lawren C., Ghilardi, Nico

“…NF-κB-inducing kinase (NIK) mediates non-canonical NF-κB signaling downstream of multiple TNF family members, including BAFF, TWEAK, CD40, and OX40, which are…”
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Comparative Immunogenicity of the 2014-2015 Northern Hemisphere Trivalent IIV and LAIV against Influenza A Viruses in Children by Ang, Jann Catherine, Wang, Biao, Wang, Joanne J F, Zeng, Peter Yu Fan, Krammer, Florian, Ward, Brian J, Russell, Margaret L, Loeb, Mark, Miller, Matthew S

“…Both inactivated influenza vaccines (IIV) and live-attenuated influenza vaccines (LAIV) have been recommended for administration to children. Children are a…”
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Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat by Fan, Peter W, Chen, Jacob Z, Allan Jaochico, M, La, Hank, Liu, Ning, Mulder, Teresa, Cass, Robert T, Durk, Matthew, Messick, Kirsten, Valle, Nicole, Liu, Shannon, Lee, Wendy, Crawford, James J, Rudolf, Joachim, Murray, Lesley J, Cyrus Khojasteh, S, Wright, Matthew

“…Significant under-prediction of in vivo clearance in rat was observed for a potent p21-activated kinase (PAK1) inhibitor, GNE1. Rate-determining (rapid uptake)…”
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Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP by Johnson, Michael G, Liu, Jim Jiwen, Li, An-Rong, van Lengerich, Bettina, Wang, Sophie, Medina, Julio C, Collins, Tassie L, Danao, Jay, Seitz, Lisa, Willee, Angela, D'Souza, Warren, Budelsky, Alison L, Fan, Peter W, Wong, Simon G W

“…Based on their structural similarity to previously described compound AMG 009, indole-phenyl acetic acids were proposed to be potent dual inhibitors of…”
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Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model System by Wang, Xiaojing, Sun, Minghua, New, Connie, Nam, Spencer, Blackaby, Wesley P, Hodges, Alastair J, Nash, David, Matteucci, Mizio, Lyssikatos, Joseph P, Fan, Peter W, Tay, Suzanne, Chang, Jae H

“…Time-dependent inhibition (TDI) of cytochrome P450 (CYP) enzymes may incur serious undesirable drug–drug interactions and in rare cases drug-induced…”
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Practical permeability-based hepatic clearance classification system (HepCCS) in drug discovery by Fan, Peter W, Song, Yang, Berezhkovskiy, Leonid M, Cheong, Jonathan, Plise, Emile G, Khojasteh, S Cyrus

“…The use of liver microsomes and hepatocytes to predict total in vivo clearance is standard practice in the pharmaceutical industry; however, metabolic…”
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