Search Results - "Fan, Junwan"
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25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model
Published in Immunity (Cambridge, Mass.) (21-03-2017)“…Zika virus (ZIKV) has become a public health threat due to its global transmission and link to severe congenital disorders. The host immune responses to ZIKV…”
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A Potent Antagonist of Smoothened in Hedgehog Signaling for Epilepsy
Published in International journal of molecular sciences (22-11-2022)“…Epilepsy is one of the common encephalopathies caused by sudden abnormal discharges of neurons in the brain. About 30% of patients with epilepsy are…”
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cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development
Published in Proceedings of the National Academy of Sciences - PNAS (02-10-2018)“…Normal neural development is essential for the formation of neuronal networks and brain function. Cutaneous T cell lymphoma-associated antigen 5…”
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Mea6 controls VLDL transport through the coordinated regulation of COPII assembly
Published in Cell research (01-07-2016)“…Lipid accumulation, which may be caused by the disturbance in very low density lipoprotein (VLDL) secretion in the liver, can lead to fatty liver disease. VLDL…”
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Identification of a potent antagonist of smoothened in hedgehog signaling
Published in Cell & bioscience (02-03-2021)“…Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for…”
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Pertussis toxin–induced inflammatory response exacerbates intracerebral haemorrhage and ischaemic stroke in mice
Published in Stroke and vascular neurology (01-02-2022)“…BackgroundStroke is a devastating disease, including intracerebral haemorrhage (ICH) and ischaemic stroke. Emerging evidences indicate that systemic…”
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Cellular and molecular imaging for stem cell tracking in neurological diseases
Published in Stroke and vascular neurology (01-03-2021)“…Stem cells (SCs) are cells with strong proliferation ability, multilineage differentiation potential and self-renewal capacity. SC transplantation represents…”
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Wild-Type p53-Induced Phosphatase 1 Plays a Positive Role in Hematopoiesis in the Mouse Embryonic Head
Published in Frontiers in cell and developmental biology (17-09-2021)“…The first adult repopulating hematopoietic stem cells (HSCs) are found in the aorta-gonad-mesonephros (AGM) region, which are produced from hemogenic…”
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cTAGE5 deletion in pancreatic β cells impairs proinsulin trafficking and insulin biogenesis in mice
Published in The Journal of cell biology (04-12-2017)“…Proinsulin is synthesized in the endoplasmic reticulum (ER) in pancreatic β cells and transported to the Golgi apparatus for proper processing and secretion…”
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APOE from patient-derived astrocytic extracellular vesicles alleviates neuromyelitis optica spectrum disorder in a mouse model
Published in Science translational medicine (28-02-2024)“…Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy of the central nervous system, mediated by antibodies against aquaporin-4 water…”
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Mea6 controls VLDL transport through the coordinated regulation of COPil assembly
Published in 细胞研究:英文版 (2016)“…Lipid accumulation, which may be caused by the disturbance in very low density lipoprotein (VLDL) secretion in the liver, can lead to fatty liver disease. VLDL…”
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