Search Results - "Fan, Heli"

Coumarin-Induced DNA Ligation, Rearrangement to DNA Interstrand Crosslinks, and Photorelease of Coumarin Moiety by Sun, Huabing, Fan, Heli, Eom, Hyeyoung, Peng, Xiaohua

“…Coumarin moieties react with thymine and cytosine in DNA by photoinduced [2+2] cycloaddition, which allows quantitative DNA interstrand crosslink (ICL)…”
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Quantitative DNA Interstrand Cross-Link Formation by Coumarin and Thymine: Structure Determination, Sequence Effect, and Fluorescence Detection by Sun, Huabing, Fan, Heli, Peng, Xiaohua

“…The coumarin analogues have been widely utilized in medicine, biology, biochemistry, and material sciences. Here, we report a detailed study on the reactivity…”
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Effect of Triazole-Modified Thymidines on DNA and RNA Duplex Stability by Fan, Heli, Sun, Huabing, Haque, Mohammad Mojibul, Peng, Xiaohua

“…Previous reports showed that consecutive incorporations of triazole-modified 2′-deoxyuridines stabilized DNA·DNA and DNA·RNA duplexes due to additional…”
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Photoinduced DNA Interstrand Cross-Linking by Benzene Derivatives: Leaving Groups Determine the Efficiency of the Cross-Linker by Fan, Heli, Peng, Xiaohua

“…We have synthesized and characterized two small libraries of 2-OMe or 2-NO2-benzene analogues 2a–i and 3a–i containing a wide variety of leaving groups…”
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Substituents Have a Large Effect on Photochemical Generation of Benzyl Cations and DNA Cross‐Linking by Fan, Heli, Sun, Huabing, Peng, Xiaohua

“…Photoactivated DNA interstrand cross‐linking agents have a wide range of biological applications. Recently, several aryl boronates have been reported to induce…”
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Photoinduced DNA Interstrand Cross‐Linking by 1,1′‐Biphenyl Analogues: Substituents and Leaving Groups Combine to Determine the Efficiency of Cross‐Linker by Fan, Heli, Sun, Huabing, Zhang, Qi, Peng, Xiaohua

“…Two series of 1,1′‐biphenyl analogues with various leaving groups (L=OAc, OCH3, OCHCH=CH2, OCH2Ph, SPh, SePh, and Ph3P+) were synthesized. Their reactivity…”
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Design, Synthesis, and Characterization of Binaphthalene Precursors as Photoactivated DNA Interstrand Cross-Linkers by Lin, Zechao, Fan, Heli, Zhang, Qi, Peng, Xiaohua

“…Most recently, alkylation via photogenerated carbocations has been identified as a novel mechanism for photoinduced DNA interstrand cross-link (ICL) formation…”
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Dual-responsive probe and DNA interstrand crosslink precursor target the unique redox status of cancer cells by Yu, Dehao, Wang, Luo, Li, Jingao, Zeng, Xuanwei, Jia, Yuanyuan, Tian, Junyu, Campbell, Anahit, Sun, Huabing, Fan, Heli

“…Elevated GSH and H O in cancer cells is sometimes doubted due to their contrary reactivities. Here, we construct a dual-responsive fluorescent probe to confirm…”
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Glutathione-dependent degradation of SMARCA2/4 for targeted lung cancer therapy with improved selectivity by Ji, Ming, Yu, Dehao, Liu, Xinmin, Wang, Luo, Zhang, Dongli, Yang, Zhengduo, Huang, Wanqiao, Fan, Heli, Wang, Lulu, Sun, Huabing

“…SMARCA2 and SMARCA4 are the mutually exclusive catalytic subunits of the mammalian Switch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex, and…”
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Redox-inducible Radiomimetic Photosensitizers Selectively Suppress Cancer Cell Proliferation by Damaging DNA through Radical Cation Chemistry by Sun, Huabing, Fan, Heli, Wang, Luo, Zeng, Xuanwei, Xiong, Chenghe, Yu, Dehao, Zhang, Xiaofan, Chen, Jiayi, Meng, Zhaowei, Campbell, Anahit, Huang, Wanqiao, Mei, Hui

“…Radiotherapy leverages ionizing radiation to kill cancer cells through direct and indirect effects, and direct effects are considered to play an equal or…”
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Rapid GSH detection and versatile peptide/protein labelling to track cell penetration using coumarin-based probes by Xue, Li, Yu, Dehao, Sun, Jing, Guan, Liangyu, Xie, Chengzhi, Wang, Luo, Jia, Yuanyuan, Tian, Junyu, Fan, Heli, Sun, Huabing

“…Biothiols play essential roles in balancing the redox state and modulating cellular functions. Fluorescent probes for monitoring/labelling biothiols often…”
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Discovery and Optimization of Novel Hydrogen Peroxide Activated Aromatic Nitrogen Mustard Derivatives as Highly Potent Anticancer Agents by Chen, Wenbing, Fan, Heli, Balakrishnan, Kumudha, Wang, Yibin, Sun, Huabing, Fan, Yukai, Gandhi, Varsha, Arnold, Leggy A, Peng, Xiaohua

“…We describe several new aromatic nitrogen mustards with various aromatic substituents and boronic esters that can be activated with H2O2 to efficiently…”
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Photoinduced DNA Interstrand Cross-Link Formation by Naphthalene Boronates via a Carbocation by Wang, Yibin, Lin, Zechao, Fan, Heli, Peng, Xiaohua

“…Most photoinduced DNA cross‐link formation by a bifunctional aryl derivative is through a bisquinone methide. DNA cross‐linking via a bisarylcarbocation…”
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Light and hydrogen peroxide dual-responsive DNA interstrand crosslink precursors with potent cytotoxicity by Jia, Yuanyuan, Sun, Jing, Yu, Dehao, Wang, Luo, Campbell, Anahit, Fan, Heli, Sun, Huabing

“…Photo/H2O2 dual-responsive precursors can be activated only in the presence of H2O2 and photoirradiation, releasing reactive quinone methides to crosslink DNA…”
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Hydrogen Peroxide‐Inducible PROTACs for Targeted Protein Degradation in Cancer Cells by Yu, Dehao, Fan, Heli, Zhou, Zhili, Zhang, Ying, Sun, Jing, Wang, Luo, Jia, Yuanyuan, Tian, Junyu, Campbell, Anahit, Mi, Wenyi, Sun, Huabing

“…Proteolysis‐targeting chimeras (PROTACs) provide a powerful technique to degrade targeted proteins utilizing the cellular ubiquitin‐proteasome system. The…”
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Phenyl Selenide‐Based Precursors as Hydrogen Peroxide Inducible DNA Interstrand Cross‐Linkers by Yu, Dehao, Fan, Heli, Sun, Jing, Xue, Li, Wang, Luo, Jia, Yuanyuan, Tian, Junyu, Sun, Huabing

“…DNA interstrand crosslinks (ICLs) are highly toxic DNA lesions, and induce cell death by blocking DNA strand separation. Most ICL agents aiming to kill cancer…”
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Glutathione-responsive PROTAC for targeted degradation of ERα in breast cancer cells by Zhou, Zhili, Fan, Heli, Yu, Dehao, Shi, Fengying, Li, Qianqian, Zhang, Zhenjian, Wang, Xiaolu, Zhang, Xuejun, Dong, Cheng, Sun, Huabing, Mi, Wenyi

“…ERα (estrogen receptor-α)-targeting PROTACs (PROteolysis TArgeting Chimeras) have emerged as a novel and promising modality for breast cancer therapeutics…”
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Selective degradation of BRD4 suppresses lung cancer cell proliferation using GSH-responsive PROTAC precursors by Fan, Heli, Zhou, Zhili, Yu, Dehao, Sun, Jing, Wang, Luo, Jia, Yuanyuan, Tian, Junyu, Mi, Wenyi, Sun, Huabing

“…PROTAC technology has moved from concept to clinical trials, but adverse effects towards normal cells undoubtedly challenge their clinical success. Taking…”
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Corrigendum: Photoinduced DNA Interstrand Cross‐Link Formation by Naphthalene Boronates via a Carbocation by Wang, Yibin, Lin, Zechao, Fan, Heli, Peng, Xiaohua

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Selective Antitumor Activity and Photocytotoxicity of Glutathione-Activated Abasic Site Trapping Agents by Xue, Li, Yu, Dehao, Wang, Lingling, Sun, Jing, Song, Ying, Jia, Yuanyuan, Wu, Ang, Zhang, Beibei, Mi, Wenyi, Fan, Heli, Sun, Huabing

“…Abasic (AP) sites are one of the most common DNA lesions in cells. Aldehyde-reactive alkoxyamines capture AP sites and block the activity of APE1, the enzyme…”
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