Search Results - "Fan, Cuiqin"
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Neuroprotective Effects of Ginsenoside-Rg1 Against Depression-Like Behaviors via Suppressing Glial Activation, Synaptic Deficits, and Neuronal Apoptosis in Rats
Published in Frontiers in immunology (07-12-2018)“…Depression is considered a neuropsychiatric disease associated with various neuronal changes within specific brain regions. We previously reported that…”
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Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression
Published in Journal of neuroinflammation (08-12-2018)“…Neuroinflammation has recently emerged as a critical risk factor in the pathophysiology of depression. However, the underlying molecular mechanisms and the…”
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MiR-134 modulates chronic stress-induced structural plasticity and depression-like behaviors via downregulation of Limk1/cofilin signaling in rats
Published in Neuropharmacology (15-03-2018)“…Increasing evidence has suggested that depression is a neuropsychiatric condition associated with neuroplasticity within specific brain regions. However, the…”
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Ginsenoside Rg1 Prevents Chronic Stress-Induced Depression-Like Behaviors and Neuronal Structural Plasticity in Rats
Published in Cellular physiology and biochemistry (01-08-2018)“…Background/Aims: Ginsenoside Rg1 has been demonstrated to exhibit neuroprotective effects in various studies. This study aimed to investigate the neuronal…”
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Neuroprotective Effects of Curcumin on IL-1β-Induced Neuronal Apoptosis and Depression-Like Behaviors Caused by Chronic Stress in Rats
Published in Frontiers in cellular neuroscience (07-01-2019)“…Depression is suggested to be a neuropsychiatric disease resulting from neuroinflammation within specific brain regions. Curcumin, a potential neuroprotective…”
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Lipin1 Alleviates Autophagy Disorder in Sciatic Nerve and Improves Diabetic Peripheral Neuropathy
Published in Molecular neurobiology (01-11-2021)“…Diabetic peripheral neuropathy (DPN) is a chronic complication of diabetes, and its neural mechanisms underlying the pathogenesis remain unclear. Autophagy…”
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MicroRNA-204-5p reduction in rat hippocampus contributes to stress-induced pathology via targeting RGS12 signaling pathway
Published in Journal of neuroinflammation (21-10-2021)“…Neuroinflammation occupies a pivotal position in the pathogenesis of most nervous system diseases, including depression. However, the underlying molecular…”
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Agomelatine rescues lipopolysaccharide-induced neural injury and depression-like behaviors via suppression of the Gαi-2-PKA-ASK1 signaling pathway
Published in Journal of neuroinflammation (24-05-2022)“…Agomelatine has been shown to be effective in the treatment of depression, but the molecular mechanisms underlying its antidepressant effects have yet to be…”
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N-Acetylcysteine Rescues Hippocampal Oxidative Stress-Induced Neuronal Injury via Suppression of p38/JNK Signaling in Depressed Rats
Published in Frontiers in cellular neuroscience (11-11-2020)“…Progression of neuronal deterioration within specific brain regions is considered as one of the principal bases for the development of major depressive…”
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Stress-induced reduction of Na + /H + exchanger isoform 1 promotes maladaptation of neuroplasticity and exacerbates depressive behaviors
Published in Science advances (11-11-2022)“…Major depression disorder (MDD) is a neuropsychiatric disorder characterized by abnormal neuronal activity in specific brain regions. A factor that is crucial…”
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Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression
Published in Molecular therapy (02-03-2022)“…Enhancing neurogenesis within the hippocampal dentate gyrus (DG) is critical for maintaining brain development and function in many neurological diseases…”
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MicroRNA-26a-3p rescues depression-like behaviors in male rats via preventing hippocampal neuronal anomalies
Published in The Journal of clinical investigation (15-08-2021)“…Depression is a neuropsychiatric disease associated with neuronal anomalies within specific brain regions. In the present study, we screened microRNA (miRNA)…”
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Hippocampal CA1 [beta]CaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression
Published in Journal of neuroinflammation (08-12-2018)“…Background Neuroinflammation has recently emerged as a critical risk factor in the pathophysiology of depression. However, the underlying molecular mechanisms…”
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Curcumin Protects Against Chronic Stress-induced Dysregulation of Neuroplasticity and Depression-like Behaviors via Suppressing IL-1β Pathway in Rats
Published in Neuroscience (10-11-2018)“…•CUMS induced depression-like behavior accompanied with neuronal structural changes in mPFC.•CUMS induced microglial activation and overexpression of…”
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Hippocampal miR-211-5p regulates neurogenesis and depression-like behaviors in the rat
Published in Neuropharmacology (15-08-2021)“…Emerging evidence has shown that microRNAs (miRNAs) contribute to the pathogenesis of depression, a potentially life-threatening and disabling mental disorder…”
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COX-2 inhibition rescues depression-like behaviors via suppressing glial activation, oxidative stress and neuronal apoptosis in rats
Published in Neuropharmacology (01-12-2019)“…Depression is considered a neuropsychiatric condition which is associated with neuronal injury within specific brain regions. We previously reported that…”
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Ginsenoside-Rg1 Rescues Stress-Induced Depression-Like Behaviors via Suppression of Oxidative Stress and Neural Inflammation in Rats
Published in Oxidative medicine and cellular longevity (2020)“…Depression is an inflammatory-related condition, with the progression in neuronal damage resulting in major depression disorder. Ginsenoside-Rg1, a sterol…”
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Neuroprotective effects of microRNA‐211‐5p on chronic stress‐induced neuronal apoptosis and depression‐like behaviours
Published in Journal of cellular and molecular medicine (01-07-2021)“…Findings from recent studies have revealed that microRNAs (miRNAs) are related to numerous neurological disorders. However, whether miRNAs regulate neuronal…”
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Interleukin-6: Its role and mechanisms in rescuing depression-like behaviors in rat models of depression
Published in Brain, behavior, and immunity (01-11-2019)“…[Display omitted] •IL-6 is decreased in CA1 hippocampus of rat depression models.•Overexpression of IL-6 suppressed neuronal abnormalities and depressive…”
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Ginsenoside Rg1 reverses stress-induced depression-like behaviours and brain-derived neurotrophic factor expression within the prefrontal cortex
Published in The European journal of neuroscience (01-07-2016)“…Depression is a major neuropsychiatric disorder that exerts deleterious effects upon public health. However, the neuronal mechanisms of depression remain…”
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