Search Results - "Fam, Maged D."

Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease by Girard, Romuald, Zeineddine, Hussein A., Orsbon, Courtney, Tan, Huan, Moore, Thomas, Hobson, Nick, Shenkar, Robert, Lightle, Rhonda, Shi, Changbin, Fam, Maged D., Cao, Ying, Shen, Le, Neander, April I., Rorrer, Autumn, Gallione, Carol, Tang, Alan T., Kahn, Mark L., Marchuk, Douglas A., Luo, Zhe-Xi, Awad, Issam A.

“…[Display omitted] •DiceCT was utilized to image lesions while preserving histologic validation.•Novel soaking technique in CCM murine model using micro-CT…”
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Patient-reported outcome following nonsurgical management of type II odontoid process fractures in adults by Fam, Maged, Zeineddine, Hussein, Nassir, Rafiq, Bhatt, Pragnesh, Kamel, Mahmoud

“…Background: Transverse (type II) odontoid process fracture is among the most commonly encountered cervical spine fractures. Nonsurgical management through…”
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Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial by Polster, Sean P, Stadnik, Agnieszka, Akers, Amy L, Cao, Ying, Christoforidis, Gregory A, Fam, Maged D, Flemming, Kelly D, Girard, Romuald, Hobson, Nicholas, Koenig, James I, Koskimäki, Janne, Lane, Karen, Liao, James K, Lee, Cornelia, Lyne, Seán B, McBee, Nichol, Morrison, Leslie, Piedad, Kristina, Shenkar, Robert, Sorrentino, Matthew, Thompson, Richard E, Whitehead, Kevin J, Zeineddine, Hussein A, Hanley, Daniel F, Awad, Issam A

“…Abstract BACKGROUND More than a million Americans harbor a cerebral cavernous angioma (CA), and those who suffer a prior symptomatic hemorrhage have an…”
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Spinal arachnoid cysts in adults: diagnosis and management. A single-center experience by Fam, Maged D, Woodroffe, Royce W, Helland, Logan, Noeller, Jennifer, Dahdaleh, Nader S, Menezes, Arnold H, Hitchon, Patrick W

“…OBJECTIVEAdult spinal arachnoid cysts (SACs) are rare entities of indistinct etiology that present with pain or myelopathy. Diagnosis is made on imaging…”
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Surgical Performance in Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation Phase III Clinical Trial by Fam, Maged D, Hanley, Daniel, Stadnik, Agnieszka, Zeineddine, Hussein A, Girard, Romuald, Jesselson, Michael, Cao, Ying, Money, Lynn, McBee, Nichol, Bistran-Hall, Amanda J, Mould, W Andrew, Lane, Karen, Camarata, Paul J, Zuccarello, Mario, Awad, Issam A

“…Abstract BACKGROUND Minimally invasive thrombolytic evacuation of intracerebral hematoma is being investigated in the ongoing phase III clinical trial of…”
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Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth by Girard, Romuald, Zeineddine, Hussein A, Koskimäki, Janne, Fam, Maged D, Cao, Ying, Shi, Changbin, Moore, Thomas, Lightle, Rhonda, Stadnik, Agnieszka, Chaudagar, Kiranj, Polster, Sean, Shenkar, Robert, Duggan, Ryan, Leclerc, David, Whitehead, Kevin J, Li, Dean Y, Awad, Issam A

“…RATIONALE:The clinical course of cerebral cavernous malformations is highly unpredictable, with few cross-sectional studies correlating proinflammatory…”
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Vascular permeability and iron deposition biomarkers in longitudinal follow-up of cerebral cavernous malformations by Girard, Romuald, Fam, Maged D, Zeineddine, Hussein A, Tan, Huan, Mikati, Abdul Ghani, Shi, Changbin, Jesselson, Michael, Shenkar, Robert, Wu, Meijing, Cao, Ying, Hobson, Nicholas, Larsson, Henrik B W, Christoforidis, Gregory A, Awad, Issam A

“…OBJECTIVE Vascular permeability and iron leakage are central features of cerebral cavernous malformation (CCM) pathogenesis. The authors aimed to correlate…”
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Phenotypic characterization of murine models of cerebral cavernous malformations by Zeineddine, Hussein A., Girard, Romuald, Saadat, Laleh, Shen, Le, Lightle, Rhonda, Moore, Thomas, Cao, Ying, Hobson, Nick, Shenkar, Robert, Avner, Kenneth, Chaudager, Kiranj, Koskimäki, Janne, Polster, Sean P., Fam, Maged D., Shi, Changbin, Lopez-Ramirez, Miguel Alejandro, Tang, Alan T., Gallione, Carol, Kahn, Mark L., Ginsberg, Mark, Marchuk, Douglas A., Awad, Issam A.

“…Cerebral cavernous malformations (CCMs) are clusters of dilated capillaries that affect around 0.5% of the population. CCMs exist in two forms, sporadic and…”
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Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations with recent hemorrhage by Zeineddine, Hussein A., Girard, Romuald, Cao, Ying, Hobson, Nicholas, Fam, Maged D., Stadnik, Agnieszka, Tan, Huan, Shen, Jingjing, Chaudagar, Kiranj, Shenkar, Robert, Thompson, Richard E., McBee, Nichol, Hanley, Daniel, Carroll, Timothy, Christoforidis, Gregory A., Awad, Issam A.

“…Background Quantitative Susceptibility Mapping (QSM) MRI allows accurate assessment of iron content in cerebral cavernous malformations (CCM), and a threshold…”
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CSF inflammatory response after intraventricular hemorrhage by Fam, Maged D, Zeineddine, Hussein A, Eliyas, Javed Khader, Stadnik, Agnieszka, Jesselson, Michael, McBee, Nichol, Lane, Karen, Cao, Ying, Wu, Meijing, Zhang, Lingjiao, Thompson, Richard E, John, Sayona, Ziai, Wendy, Hanley, Daniel F, Awad, Issam A

“…OBJECTIVE:To investigate the temporal pattern and relevant associations of CSF inflammatory measures after intraventricular hemorrhage (IVH). METHODS:We…”
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Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations by Girard, Romuald, Zeineddine, Hussein A., Fam, Maged D., Mayampurath, Anoop, Cao, Ying, Shi, Changbin, Shenkar, Robert, Polster, Sean P., Jesselson, Michael, Duggan, Ryan, Mikati, Abdul-Ghani, Christoforidis, Gregory, Andrade, Jorge, Whitehead, Kevin J., Li, Dean Y., Awad, Issam A.

“…The clinical course of cerebral cavernous malformations (CCMs) is highly variable. Based on recent discoveries implicating angiogenic and inflammatory…”
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Symptomatic Hemorrhagic Complications in Clot Lysis: Evaluation of Accelerated Resolution of Intraventricular Hemorrhage Phase III Clinical Trial (CLEAR III): A Posthoc Root-Cause Analysis by Fam, Maged D, Stadnik, Agnieszka, Zeineddine, Hussein A, Girard, Romuald, Mayo, Steven, Dlugash, Rachel, McBee, Nichol, Lane, Karen, Mould, W Andrew, Ziai, Wendy, Hanley, Daniel, Awad, Issam A

“…Abstract BACKGROUND As intraventricular thrombolysis for intraventricular hemorrhage (IVH) has developed over the last 2 decades, hemorrhagic complications…”
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Demographic Risk Factors for Vascular Lesions as Etiology of Intraventricular Hemorrhage in Prospectively Screened Cases by Fam, Maged D, Pang, Alice, Zeineddine, Hussein A, Mayo, Steven, Stadnik, Agnieszka, Jesselson, Michael, Zhang, Lingjiao, Dlugash, Rachel, Ziai, Wendy, Hanley, Daniel, Awad, Issam A

“…Spontaneous intraventricular hemorrhage (IVH) is associated with high rates of morbidity and mortality despite critical care and other advances. An important…”
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B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models by Shi, Changbin, Shenkar, Robert, Zeineddine, Hussein A., Girard, Romuald, Fam, Maged D., Austin, Cecilia, Moore, Thomas, Lightle, Rhonda, Zhang, Lingjiao, Wu, Meijing, Cao, Ying, Gunel, Murat, Louvi, Angeliki, Rorrer, Autumn, Gallione, Carol, Marchuk, Douglas A., Awad, Issam A.

“…Cerebral cavernous malformations (CCMs) are relatively common vascular malformations, characterized by increased Rho kinase (ROCK) activity, vascular…”
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Skull Base Dural Thickness and Relationship to Demographic Features: A Postmortem Study and Literature Review by Fam, Maged D, Potash, Andrea, Potash, Martin, Robinson, Robert, Karnell, Lucy, O'Brien, Erin, Greenlee, Jeremy D W

“…Dural membrane is an important anatomic structure that surrounds and protects the entire central nervous system. Physical properties of the dura have many…”
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Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease by Girard, Romuald, Khanna, Omaditya, Shenkar, Robert, Zhang, Lingjiao, Wu, Meijing, Jesselson, Michael, Zeineddine, Hussein A, Gangal, Anupriya, Fam, Maged D, Gibson, Christopher C, Whitehead, Kevin J, Li, Dean Y, Liao, James K, Shi, Changbin, Awad, Issam A

“…To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically. A prospective…”
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Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure by Awad, Issam A, Polster, Sean P, Carrión-Penagos, Julián, Thompson, Richard E, Cao, Ying, Stadnik, Agnieszka, Money, Patricia Lynn, Fam, Maged D, Koskimäki, Janne, Girard, Romuald, Lane, Karen, McBee, Nichol, Ziai, Wendy, Hao, Yi, Dodd, Robert, Carlson, Andrew P, Camarata, Paul J, Caron, Jean-Louis, Harrigan, Mark R, Gregson, Barbara A, Mendelow, A David, Zuccarello, Mario, Hanley, Daniel F

“…Abstract BACKGROUND Minimally invasive surgery procedures, including stereotactic catheter aspiration and clearance of intracerebral hemorrhage (ICH) with…”
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Abstract TMP117: Subclinical Imaging Changes in Cerebral Cavernous Angiomas During Prospective Surveillance by Carrion-Penagos, Julian, Polster, Sean P, Zeineddine, Hussein A, Fam, Maged D, Girard, Romuald, Koskimaki, Janne, Lyne, Sean, Romanos, Sharbel, Zhang, Dongdong, Srinath, Abhinav, Cao, Ying, Stadnik, Agnieszka, Piedad, Kristina, Awad, Issam A

“…Abstract only Introduction: Studies on the natural clinical course of Cavernous Angioma (CA) have reported a <0.5% annual risk of symptomatic hemorrhage (SH)…”
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Abstract WMP103: Comparative Impact of Extent of Lobar Intracerebral Hemorrhage Removal on Outcome in the MISTIE III and STICH II Trials by Polster, Sean P, Carrion-Penagos, Julian, Gregson, Barbara A, Cao, Ying, Thompson, Richard E, Stadnik, Agnieszka, Money, Patricia Lynn, Koskimaki, Janne, Lyne, Sean, Fam, Maged D, Girard, Romuald, Lane, Karen, McBee, Nichol, Ziai, Wendy, Hao, Yi, Dodd, Robert, Carlson, Andrew P, Camarata, Paul J, Caron, Jean-Louis, Harrigan, Mark R, Dawson, Jesse, Mendelow, A. David, Zuccarello, Mario, Hanley, Daniel F, Awad, Issam A

“…Abstract only Introduction: The Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation Phase III…”
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Abstract TP335: Comparative Impact of Timing From Ictus to Intracerebral Hemorrhage Evacuation on Outcome in MISTIE III, STICH I & II Trials by Polster, Sean P, Carrion-Penagos, Julian, Gregson, Barbara A, Cao, Ying, Thompson, Richard E, Stadnik, Agnieszka, Money, Patricia Lynn, Koskimaki, Janne, Lyne, Sean, Fam, Maged D, Girard, Romuald, Lane, Karen, McBee, Nichol, Ziai, Wendy, Hao, Yi, Dodd, Robert, Carlson, Andrew P, Camarata, Paul J, Caron, Jean-Louis, Harrigan, Mark R, Dawson, Jesse, Mendelow, A. David, Zuccarello, Mario, Hanley, Daniel F, Awad, Issam A

“…Abstract only Introduction: Completion of the MISTIE procedure requires a period of hematoma stability before and during hematoma removal and, if necessary,…”
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