Search Results - "Faltynek, C R"

TRPV1 Receptors in the CNS Play a Key Role in Broad-Spectrum Analgesia of TRPV1 Antagonists by Cui, M, Honore, P, Zhong, C, Gauvin, D, Mikusa, J, Hernandez, G, Chandran, P, Gomtsyan, A, Brown, B, Bayburt, E. K, Marsh, K, Bianchi, B, McDonald, H, Niforatos, W, Neelands, T. R, Moreland, R. B, Decker, M. W, Lee, C.-H, Sullivan, J. P, Faltynek, C. R

“…Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such…”
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P2X7 -related modulation of pathological nociception in rats by McGaraughty, S, Chu, K.L, Namovic, M.T, Donnelly-Roberts, D.L, Harris, R.R, Zhang, X.-F, Shieh, C.-C, Wismer, C.T, Zhu, C.Z, Gauvin, D.M, Fabiyi, A.C, Honore, P, Gregg, R.J, Kort, M.E, Nelson, D.W, Carroll, W.A, Marsh, K, Faltynek, C.R, Jarvis, M.F

“…Abstract Growing evidence supports a role for the immune system in the induction and maintenance of chronic pain. ATP is a key neurotransmitter in this…”
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Distribution and functional characterization of human Nav1.3 splice variants by Thimmapaya, R., Neelands, T., Niforatos, W., Davis-Taber, R. A., Choi, W., Putman, C. B., Kroeger, P. E., Packer, J., Gopalakrishnan, M., Faltynek, C. R., Surowy, C. S., Scott, V. E.

“…The focus of the present study is the molecular and functional characterization of four splice variants of the human Nav1.3 α subunit. These subtypes arise due…”
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Elevated circulating interleukin-7 levels in patients with systemic juvenile rheumatoid arthritis by De Benedetti, F, Massa, M, Pignatti, P, Kelley, M, Faltynek, C R, Martini, A

“…Since interleukin-7 (IL-7) has been shown to induce monocyte production of IL-1, IL-6, IL-8, and tumor necrosis factor-alpha, we investigated plasma and…”
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Distinct neurochemical mechanisms are activated following administration of different P2X receptor agonists into the hindpaw of a rat by Wismer, Carol T, Faltynek, Connie R, Jarvis, Michael F, McGaraughty, Steve

“…Nocifensive behaviors induced by the intradermal injection of three different P2X receptor agonists, ATP, BzATP or α,β-meATP, into a hindpaw were measured in…”
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Elevated temperatures alter TRPV1 agonist-evoked excitability of dorsal root ganglion neurons by Neelands, T. R., Jarvis, M. F., Faltynek, C. R., Surowy, C. S.

“… The vanilloid receptor 1 (TRPV1) is activated by capsaicin, several endogenous lipids, acidic pH and elevated temperatures. Inflammatory mediators (BK,…”
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Induction of transforming growth factor-beta 1 (TGF-beta 1), receptor expression and TGF-beta 1 protein production in retinoic acid-treated HL-60 cells: possible TGF-beta 1-mediated autocrine inhibition by Falk, L A, De Benedetti, F, Lohrey, N, Birchenall-Roberts, M C, Ellingsworth, L W, Faltynek, C R, Ruscetti, F W

“…Treatment of HL-60 cells, a human promyelocytic leukemia cell line, with the vitamin A derivative retinoic acid (RA) for 7 days resulted in a dose-dependent…”
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Recombinant human IL-7 administration in mice affects colony-forming units-spleen and lymphoid precursor cell localization and accelerates engraftment of bone marrow transplants by Boerman, O C, Gregorio, T A, Grzegorzewski, K J, Faltynek, C R, Kenny, J J, Wiltrout, R H, Komschlies, K L

“…Murine reconstitution assays were used to investigate the effects of recombinant human interleukin-7 (rhIL-7) on myeloid and lymphoid precursors and on bone…”
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Capsaicin Infused Into the PAG Affects Rat Tail Flick Responses to Noxious Heat and Alters Neuronal Firing in the RVM by McGaraughty, Steve, Chu, Katharine L, Bitner, Robert S, Martino, Brenda, Kouhen, Rachid El, Han, Ping, Nikkel, Arthur L, Burgard, Edward C, Faltynek, Connie R, Jarvis, Michael F

“…Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 Submitted 6 May 2003; accepted in final…”
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Synergy Between Transforming Growth Factor-β and Tumor Necrosis Factor-α in the Induction of Monocytic Differentiation of Human Leukemic Cell Lines by Benedetti, Fabrizio De, Falk, Lydia A., Ellingsworth, Larry R., Ruscetti, Francis W., Faltynek, Connie R.

“…We examined the effect of transforming growth factor-β (TGF-β) alone and in combinations with other factors on the growth and differentiation of the human…”
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Augmentation of cell-mediated immunotherapy against herpes simplex virus by interleukins: comparison of in vivo effects of IL-2 and IL-7 on adoptively transferred T cells by Wiryana, Purwani, Bui, Tot, Faltynek, Connie R., Ho, Rodney J.Y.

“…We investigated the ability of human recombinant interleukin-7 (IL-7) to enhance cytotoxic T lymphocyte (CTL) activity in vivo using mice infected with herpes…”
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A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats by Honore, Prisca, Wismer, Carol T, Mikusa, Joe, Zhu, Chang Z, Zhong, Chengmin, Gauvin, Donna M, Gomtsyan, Arthur, El Kouhen, Rachid, Lee, Chih-Hung, Marsh, Kennan, Sullivan, James P, Faltynek, Connie R, Jarvis, Michael F

“…The vanilloid receptor 1 (VR1, TRPV1), which is a member of the transient receptor potential (TRP) superfamily, is highly localized on peripheral and central…”
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Administration of recombinant human interleukin-7 to mice induces the exportation of myeloid progenitor cells from the bone marrow to peripheral sites by GRZEGORZEWSKI, K, KOMSCHLIES, K. L, MORI, M, KANEDA, K, USUI, N, FALTYNEK, C. R, KELLER, J. R, RUSCETTI, F. W, WILTROUT, R. H

“…The administration of recombinant human interleukin-7 (rhIL-7) to mice twice a day for 7 days does not appreciably change bone marrow (BM) cellularity, but…”
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Treatment with recombinant IFN-γ decreases cell surface CD4 levels on peripheral blood monocytes and on myelomonocytic cell lines by FALTYNEK, C. R, FINCH, L. R, MILLER, P, OVERTON, W. R

“…The human cell surface protein CD4 is not only an important accessory molecule in the activation of MHC class-II-restricted T cells, but has also been…”
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A Functional Protein Kinase C Is Required for Induction of 2-5A Synthetase by Recombinant Interferon-αA in Daudi Cells by Faltynek, C R, Princler, G L, Gusella, G L, Varesio, L, Radzioch, D

“…Treatment of Daudi B lymphoblastoid cells with interferon (IFN)-α or -β has been reported (Yap, W. H., Teo, T. S., and Tan, Y. H. (1986) Science 234, 355–358)…”
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Administration of Recombinant Human Interleukin-7 Alters the Frequency and Number of Myeloid Progenitor Cells in the Bone Marrow and Spleen of Mice by Damia, Giovanna, Komschlies, Kristin L., Faltynek, Connie R., Ruscetti, Francis W., Wiltrout, Robert H.

“…The administration of ≥ 5 μg interleukin-7 (IL-7) twice a day to mice for 4 to 7 days increased by twofold to fivefold the total number of splenic and…”
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Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats by Honore, Prisca, Kage, Karen, Mikusa, Joseph, Watt, Andrew T, Johnston, Joseph F, Wyatt, Jacqueline R, Faltynek, Connie R, Jarvis, Michael F, Lynch, Kevin

“…Extracellular adenosine triphosphate (ATP), acting at P2X ionotropic receptors, is implicated in numerous sensory processes. Exogenous ATP has been shown to be…”
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Interaction of interferon with cellular receptors. Internalization and degradation of cell-bound interferon by Branca, A A, Faltynek, C R, D'Alessandro, S B, Baglioni, C

“…Human interferon alpha A, produced in Escherichia coli by recombinant DNA technology, was labeled with 125I to study its binding to receptors on human…”
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Lectins modulate the internalization of recombinant interferon-alpha A and the induction of 2‘,5‘-oligo(A) synthetase by Faltynek, C R, Princler, G L, Ruscetti, F W, Birchenall-Sparks, M

“…After binding to specific cell surface receptors, interferon-alpha (IFN-alpha) along with its receptor is internalized by the cells. However, the physiological…”
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Interferons in host defense by Faltynek, C R, Oppenheim, J J

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