Search Results - "Fallon, J T"

Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers by BEERI, M. S, RAPP, M, ROSENDORFF, C, HAROUTUNIAN, V, SILVERMAN, J. M, SCHMEIDLER, J, GROSSMAN, H. T, FALLON, J. T, PUROHIT, D. P, PERI, D. P, SIDDIQUI, A, LESSER, G

“…To examine the associations between postmortem Alzheimer disease (AD) neuropathology and autopsy-verified cardiovascular disease. The authors examined 99…”
Get full text

Macrophage infiltration in acute coronary syndromes : implications for plaque rupture by MORENO, P. R, FALK, E, PALACIOS, I. F, NEWELL, J. B, FUSTER, V, FALLON, J. T

“…Rupture of atherosclerotic plaques is probably the most important mechanism underlying the sudden onset of acute coronary syndromes. Macrophages may release…”
Get full text

Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques : potential role of matrix-degrading metalloproteinases and implications for plaque rupture by SHAH, P. K, FALK, E, BADIMON, J. J, FERNANDEZ-ORTIZ, A, MAILHAC, A, VILLAREAL-LEVY, G, FALLON, J. T, REGNSTROM, J, FUSTER, V

“…Rupture of the fibrous cap of the atherosclerotic plaque is a key event that predisposes to coronary thrombosis, leading to acute coronary syndromes. Recent…”
Get full text

Noninvasive in vivo human coronary artery lumen and wall imaging using black-blood magnetic resonance imaging by FAYAD, Z. A, FUSTER, V, FALLON, J. T, JAYASUNDERA, T, WORTHLEY, S. G, HELFT, G, AGUINALDO, J. G, BADIMON, J. J, SHARMA, S. K

“…High-resolution MRI has the potential to noninvasively image the human coronary artery wall and define the degree and nature of coronary artery disease…”
Get full text

A Phase 1/2 Clinical Trial of Enzyme Replacement in Fabry Disease: Pharmacokinetic, Substrate Clearance, and Safety Studies by Eng, Christine M., Banikazemi, Maryam, Gordon, Ronald E., Goldman, Martin, Phelps, Robert, Kim, Leona, Gass, Alan, Winston, Jonathan, Dikman, Steven, Fallon, John T., Brodie, Scott, Stacy, Charles B., Mehta, Davendra, Parsons, Rosaleen, Norton, Karen, O’Callaghan, Michael, Desnick, Robert J.

“…Fabry disease results from deficient α-galactosidase A (α-Gal A) activity and the pathologic accumulation of the globotriaosylceramide (GL-3) and related…”
Get full text

Statins and cardiovascular diseases: the multiple effects of lipid-lowering therapy by statins by Rauch, U., Osende, J.I., Chesebro, J.H., Fuster, V., Vorchheimer, D.A., Harris, K., Harris, P., Sandler, D.A., Fallon, J.T., Jayaraman, S., Badimon, J.J.

“…Cholesterol lowering involving different therapies improves the clinical outcome of patients. To define the underlying pathomechanism, we studied whether…”
Get full text

The Diagnostic Accuracy of Ex Vivo MRI for Human Atherosclerotic Plaque Characterization by Shinnar, Meir, Fallon, John T, Wehrli, Suzanne, Levin, Michael, Dalmacy, Dolcine, Fayad, Zahi A, Badimon, Juan J, Harrington, Martin, Harrington, Elizabeth, Fuster, Valentin

“…Recent evidence indicates that the type of atherosclerotic plaque, rather than the degree of obstruction to flow, is an important determinant of the risk of…”
Get full text

Tissue factor modulates the thrombogenicity of human atherosclerotic plaques by TOSCHI, V, GALLO, R, BADIMON, J. J, LETTINO, M, FALLON, J. T, GERTZ, S. D, FERNANDEZ-ORTIZ, A, CHESEBRO, J. H, BADIMON, L, NEMERSON, Y, FUSTER, V

“…The thrombogenicity of a disrupted atherosclerotic lesion is dependent on the nature and extent of the plaque components exposed to flowing blood together with…”
Get full text

Mouse Model of Femoral Artery Denudation Injury Associated With the Rapid Accumulation of Adhesion Molecules on the Luminal Surface and Recruitment of Neutrophils by Roque, Merce, Fallon, John T, Badimon, Juan J, Zhang, Wen X, Taubman, Mark B, Reis, Ernane D

“…ABSTRACTTechniques of arterial injury commonly used in animals to mimic endovascular procedures are not suitable for small mouse arteries. This has limited…”
Get full text

Characterization of aortic root atherosclerosis in ApoE knockout mice: High-resolution in vivo and ex vivo MRM with histological correlation by Itskovich, V.V., Choudhury, R.P., Aguinaldo, J.G.S., Fallon, J.T., Omerhodzic, S., Fisher, E.A., Fayad, Z.A.

“…In vivo, cardiac‐gated, black‐blood, and ex vivo magnetic resonance microscopy (MRM) images of the aortic root, and histopathology data were obtained from 12…”
Get full text

Bone morphogenetic protein -7 increases thrombogenicity of lipid-rich atherosclerotic plaques via activation of tissue factor by Sovershaev, M.A, Egorina, E.M, Bogdanov, V.Y, Seredkina, N, Fallon, J.T, Valkov, A.Y, Østerud, B, Hansen, J.B

“…Abstract Thrombogenicity of atherosclerotic plaques largely depends on plaque morphology. Tissue factor (TF) expression is higher in lipid-rich than in…”
Get full text

Tumor Lysis Syndrome Occurring After the Administration of Rituximab for Posttransplant Lymphoproliferative Disorder by Francescone, S.A, Murphy, B, Fallon, J.T, Hammond, K, Pinney, S

“…Abstract Tumor lysis syndrome (TLS) may occur after the administration of rituximab for lymphoproliferative disorders. We describe the case of a heart…”
Get full text

Macrophages, smooth muscle cells, and tissue factor in unstable angina : Implications for cell-mediated thrombogenicity in acute coronary syndromes by MORENO, P. R, BERNARDI, V. H, FALLON, J. T, LOPEZ-CUELLAR, J, MURCIA, A. M, PALACIOS, I. F, GOLD, H. K, MEHRAN, R, SHARMA, S. K, NEMERSON, Y, FUSTER, V

“…Macrophage expression of tissue factor may be responsible for coronary thrombogenicity in patients with plaque rupture. In patients without plaque rupture,…”
Get full text

Dietary lipid lowering reduces tissue factor expression in rabbit atheroma by AIKAWA, M, VOGLIC, S. J, SUGIYAMA, S, RABKIN, E, TAUBMAN, M. B, FALLON, J. T, LIBBY, P

“…The mechanisms by which lipid lowering reduces the incidence of acute thrombotic complications of coronary atheroma in clinical trials remains unknown. Tissue…”
Get full text

Noninvasive in vivo high-resolution magnetic resonance imaging of atherosclerotic lesions in genetically engineered mice by FAYAD, Z. A, FALLON, J. T, FUSTER, V, SHINNAR, M, WEHRLI, S, DANSKY, H. M, POON, M, BADIMON, J. J, CHARLTON, S. A, FISHER, E. A, BRESLOW, J. L

“…The pathogenesis of atherosclerosis is currently being investigated in genetically engineered small animals. Methods to follow the time course of the…”
Get full text

Inhibition of tissue factor limits the growth of venous thrombus in the rabbit by Himber, J., Wohlgensinger, C., Roux, S., Damico, L. A., Fallon, J. T., Kirchhofer, D., Nemerson, Y., Riederer, M. A.

“…Antibody mediated inhibition of tissue factor (TF) function reduces thrombus size in ex vivo perfusion of human blood over a TF‐free surface at venous shear…”
Get full text

Refractory humoral cardiac allograft rejection successfully treated with a single dose of rituximab by Baran, D.A., Lubitz, S., Alvi, S., Fallon, J.T., Kaplan, S., Galin, I., Correa, R., Courtney, M.C., Chan, M., Spielvogel, D., Lansman, S.L., Gass, A.L.

“…Despite improvements in immunosuppression over the last two decades, the risk of allograft rejection is still high in the early postoperative period. Cellular…”
Get full text

Release of Active Tissue Factor by Human Arterial Smooth Muscle Cells by Schecter, Alison D, Spirn, Benjamin, Rossikhina, Maria, Giesen, Peter L. A, Bogdanov, Vladimir, Fallon, John T, Fisher, Edward A, Schnapp, Lynn M, Nemerson, Yale, Taubman, Mark B

“…Tissue factor (TF), the initiator of coagulation, is thought to function predominantly at the cell surface. Recent data have suggested that active TF is…”
Get full text

Identification of active tissue factor in human coronary atheroma by MARMUR, J. D, THIRUVIKRAMAN, S. V, FYFE, B. S, GUHA, A, SHARMA, S. K, AMBROSE, J. A, FALLON, J. T, NEMERSON, Y, TAUBMAN, M. B

“…Recent observations suggest that thrombosis in vivo is initiated via the tissue factor (TF) pathway. The TF activity of human coronary atheroma has not been…”
Get full text

In situ localization of tissue factor in human atherosclerotic plaques by binding of digoxigenin-labeled factors VIIa and X by Thiruvikraman, S V, Guha, A, Roboz, J, Taubman, M B, Nemerson, Y, Fallon, J T

“…The mechanism responsible for the thrombotic complications of atherosclerotic plaques is not well understood. Although a role for tissue factor (TF) has been…”
Get more information