Search Results - "Fallica, Antonino N."

Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective by Fallica, Antonino N, Pittalà, Valeria, Modica, Maria N, Salerno, Loredana, Romeo, Giuseppe, Marrazzo, Agostino, Helal, Mohamed A, Intagliata, Sebastiano

“…Since their discovery as distinct receptor proteins, the specific physiopathological role of sigma receptors (σRs) has been deeply investigated. It has been…”
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The Promise of Nanotechnology in Personalized Medicine by Alghamdi, Maha Ali, Fallica, Antonino N, Virzì, Nicola, Kesharwani, Prashant, Pittalà, Valeria, Greish, Khaled

“…Both personalized medicine and nanomedicine are new to medical practice. Nanomedicine is an application of the advances of nanotechnology in medicine and is…”
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Novel mutual prodrug of 5-fluorouracil and heme oxygenase-1 inhibitor (5-FU/HO-1 hybrid): design and preliminary in vitro evaluation by Salerno, Loredana, Vanella, Luca, Sorrenti, Valeria, Consoli, Valeria, Ciaffaglione, Valeria, Fallica, Antonino N., Canale, Vittorio, Zajdel, Paweł, Pignatello, Rosario, Intagliata, Sebastiano

“…In this work, the first mutual prodrug of 5-fluorouracil and heme oxygenase1 inhibitor (5-FU/HO-1 hybrid) has been designed, synthesised, and evaluated for its…”
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Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors by Intagliata, Sebastiano, Salerno, Loredana, Ciaffaglione, Valeria, Leonardi, Carmen, Fallica, Antonino N., Carota, Giuseppe, Amata, Emanuele, Marrazzo, Agostino, Pittalà, Valeria, Romeo, Giuseppe

“…Heme oxygenase (HO) enzymes are involved in heme catabolism and several physiological functions. Among the different HO isoforms, HO-2 stands out for its…”
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Structure-activity relationships of mixed σ1R/σ2R ligands with antiproliferative and anticancer effects by Fallica, Antonino N., Ciaffaglione, Valeria, Modica, Maria N., Pittalà, Valeria, Salerno, Loredana, Amata, Emanuele, Marrazzo, Agostino, Romeo, Giuseppe, Intagliata, Sebastiano

“…[Display omitted] The overexpression of σ receptors (σRs) in various types of tumors has prompted a deep investigation of their role in cancer pathophysiology…”
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Growing the molecular architecture of imidazole-like ligands in HO-1 complexes by Floresta, Giuseppe, Fallica, Antonino N., Salerno, Loredana, Sorrenti, Valeria, Pittalà, Valeria, Rescifina, Antonio

“…[Display omitted] •Structure-guided fragment-based approach to identify new compounds as HO-1 inhibitors.•Virtual growing experiments of the classical HO-1…”
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Curcumin I-SMA nanomicelles as promising therapeutic tool to tackle bacterial infections by Virzì, Nicola F, Fallica, Antonino N, Romeo, Giuseppe, Greish, Khaled, Alghamdi, Maha Ali, Patanè, Salvatore, Mazzaglia, Antonino, Shahid, Mohammad, Pittalà, Valeria

“…Renewed interest towards natural substances has been pushed by the widespread diffusion of antibiotic resistance. Curcumin I is the most active and effective…”
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Discovery of Novel Acetamide-Based Heme Oxygenase‑1 Inhibitors with Potent In Vitro Antiproliferative Activity by Fallica, Antonino N, Sorrenti, Valeria, D’Amico, Agata G, Salerno, Loredana, Romeo, Giuseppe, Intagliata, Sebastiano, Consoli, Valeria, Floresta, Giuseppe, Rescifina, Antonio, D’Agata, Velia, Vanella, Luca, Pittalà, Valeria

“…Heme oxygenase-1 (HO-1) promotes heme catabolism exercising cytoprotective roles in normal and cancer cells. Herein, we report the design, synthesis, molecular…”
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Identification of a potent heme oxygenase-2 (HO-2) inhibitor by targeting the secondary hydrophobic pocket of the HO-2 western region by Floresta, Giuseppe, Fallica, Antonino N., Romeo, Giuseppe, Sorrenti, Valeria, Salerno, Loredana, Rescifina, Antonio, Pittalà, Valeria

“…[Display omitted] •HO-2 selective inhibitors have been designed.•Selectivity switch from HO-1 to HO-2 was obtained by increasing the volume of the…”
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Synthesis and in Vitro Evaluation of CAPE Derivatives as Ferroptosis Inducers in Triple Negative Breast Cancer by Consoli, Valeria, Fallica, Antonino N., Virzì, Nicola F., Salerno, Loredana, Intagliata, Sebastiano, Sorrenti, Valeria, Greish, Khaled, Giuffrida, Alessandro, Vanella, Luca, Pittalà, Valeria

“…Herein, we describe the design, synthesis, and in vitro biological evaluation of HO-1 inducers endowed with cytotoxic effects mediated by ferroptosis…”
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The Potential Role of Sildenafil in Cancer Management through EPR Augmentation by Haider, Mohamed, Elsherbeny, Amr, Pittalà, Valeria, Fallica, Antonino N., Alghamdi, Maha Ali, Greish, Khaled

“…Enhanced permeation retention (EPR) was a significant milestone discovery by Maeda et al. paving the path for the emerging field of nanomedicine to become a…”
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Novel mutual prodrug of 5-fluorouracil and heme oxygenase-1 inhibitor (5-FU/HO-1 hybrid): design and preliminary in vitro evaluation by Salerno, Loredana, Vanella, Luca, Sorrenti, Valeria, Consoli, Valeria, Ciaffaglione, Valeria, Fallica, Antonino N., Canale, Vittorio, Zajdel, Paweł, Pignatello, Rosario, Intagliata, Sebastiano

“…In this work, the first mutual prodrug of 5-fluorouracil and heme oxygenase1 inhibitor (5-FU/HO-1 hybrid) has been designed, synthesised, and evaluated for its…”
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