Search Results - "Faller, Michele"

Lung Cancer That Harbors an HER2 Mutation: Epidemiologic Characteristics and Therapeutic Perspectives by Mazières, Julien, Peters, Solange, Lepage, Benoit, Cortot, Alexis B., Barlesi, Fabrice, Beau-Faller, Michéle, Besse, Benjamin, Blons, Hélène, Mansuet-Lupo, Audrey, Urban, Thierry, Moro-Sibilot, Denis, Dansin, Eric, Chouaid, Christos, Wislez, Marie, Diebold, Joachim, Felip, Enriqueta, Rouquette, Isabelle, Milia, Julie D., Gautschi, Oliver

“…HER2 mutations are identified in approximately 2%of non-small-cell lung cancers (NSCLC). There are few data available that describe the clinical course of…”
Get full text

Prognostic and Predictive Biomarkers in the Era of Immunotherapy for Lung Cancer by Pabst, Lucile, Lopes, Sébastien, Bertrand, Basil, Creusot, Quentin, Kotovskaya, Maria, Pencreach, Erwan, Beau-Faller, Michèle, Mascaux, Céline

“…The therapeutic algorithm of lung cancer has recently been revolutionized by the emergence of immune checkpoint inhibitors. However, an objective and durable…”
Get full text

Molecular Mechanism of EGFR-TKI Resistance in EGFR -Mutated Non-Small Cell Lung Cancer: Application to Biological Diagnostic and Monitoring by Reita, Damien, Pabst, Lucile, Pencreach, Erwan, Guérin, Eric, Dano, Laurent, Rimelen, Valérie, Voegeli, Anne-Claire, Vallat, Laurent, Mascaux, Céline, Beau-Faller, Michèle

“…Non-small cell lung cancer (NSCLC) is the most common cancer in the world. Activating epidermal growth factor receptor ( ) gene mutations are a positive…”
Get full text

Direct Targeting KRAS Mutation in Non-Small Cell Lung Cancer: Focus on Resistance by Reita, Damien, Pabst, Lucile, Pencreach, Erwan, Guérin, Eric, Dano, Laurent, Rimelen, Valérie, Voegeli, Anne-Claire, Vallat, Laurent, Mascaux, Céline, Beau-Faller, Michèle

“…KRAS is the most frequently mutated oncogene in non-small cell lung cancers (NSCLC), with a frequency of around 30%, and encoding a GTPAse that cycles between…”
Get full text

Therapeutic strategy for advanced EGFR mutant non-small-cell lung carcinoma by Cadranel, Jacques, Ruppert, Anne-Marie, Beau-Faller, Michèle, Wislez, Marie

“…Abstract Activating mutation in exons 19 or 21 of epidermal growth factor receptor (EGFR) in non-small-cell lung cancers (NSCLC) are associated with increased…”
Get full text

Specific KRAS amino acid substitutions and EGFR mutations predict site-specific recurrence and metastasis following non-small-cell lung cancer surgery by Renaud, Stéphane, Seitlinger, Joseph, Falcoz, Pierre-Emmanuel, Schaeffer, Mickaël, Voegeli, Anne-Claire, Legrain, Michèle, Beau-Faller, Michèle, Massard, Gilbert

“…Background: We aimed to evaluate whether EGFR mutations ( mEGFR ) and KRAS amino acid substitutions can predict first site of recurrence or metastasis after…”
Get full text

Characteristics and Outcomes of Patients with Lung Cancer Harboring Multiple Molecular Alterations: Results from the IFCT Study Biomarkers France by Guibert, Nicolas, Barlesi, Fabrice, Descourt, Renaud, Léna, Hervé, Besse, Benjamin, Beau-Faller, Michèle, Mosser, Jean, Pichon, Eric, Merlio, Jean-Philippe, Ouafik, L'Houcine, Guichard, François, Mastroianni, Bénédicte, Moreau, Lionel, Wdowik, Annie, Sabourin, Jean-Christophe, Lemoine, Antoinette, Missy, Pascale, Langlais, Alexandra, Moro-Sibilot, Denis, Mazières, Julien

“…Little is known about the prevalence, prognosis, and response to treatment of advanced NSCLC harboring multiple genomic alterations. The French Biomarkers…”
Get more information

Epidermal growth factor receptor mutations are linked to skip N2 lymph node metastasis in resected non-small-cell lung cancer adenocarcinomas by Guerrera, Francesco, Renaud, Stéphane, Tabbó, Fabrizio, Voegeli’, Anne-Claire, Filosso, Pier Luigi, Legrain, Michèle, Boita, Monica, Schaeffer, Mickaël, Beau-Faller, Michèle, Ruffini, Enrico, Falcoz, Pierre-Emmanuel, Inghirami, Giorgio, Oliaro, Alberto, Massard, Gilbert

“…Abstract OBJECTIVES: The impact of skip N2 metastases (i.e. N2 lymph node metastases without N1) on survival in surgically resected non-small lung cancer…”
Get full text

Prognostic value of the KRAS G12V mutation in 841 surgically resected Caucasian lung adenocarcinoma cases by Renaud, Stéphane, Falcoz, Pierre-Emmanuel, Schaëffer, Mickaël, Guenot, Dominique, Romain, Benoit, Olland, Anne, Reeb, Jérémie, Santelmo, Nicola, Chenard, Marie-Pierre, Legrain, Michèle, Voegeli, Anne-Claire, Beau-Faller, Michèle, Massard, Gilbert

“…Background: Identifying patients who will experience lung cancer recurrence after surgery remains a challenge. We aimed to evaluate whether mutant forms of…”
Get full text

High MET Overexpression Does Not Predict the presence of MET exon 14 Splice Mutations in NSCLC: Results From the IFCT PREDICT.amm study by Baldacci, Simon, Figeac, Martin, Antoine, Martine, Descarpentries, Clotilde, Kherrouche, Zoulika, Jamme, Philippe, Copin, Marie-Christine, Tulasne, David, Nanni, Isabelle, Beau-Faller, Michèle, Melaabi, Samia, Levallet, Guénaëlle, Quoix, Elisabeth, Moro-Sibilot, Denis, Friard, Sylvie, Missy, Pascale, Barlesi, Fabrice, Cadranel, Jacques, Cortot, Alexis B

“…MET proto-oncogene (MET) exon 14 splice site (METex14) mutations were recently described in NSCLC and has been reported to correlate with efficacy of MET…”
Get more information

A Comparative and Integrative Approach Identifies ATPase Family, AAA Domain Containing 2 as a Likely Driver of Cell Proliferation in Lung Adenocarcinoma by FOURET, Robert, LAFFAIRE, Julien, SORIA, Jean-Charles, FOURET, Pierre, HOFMAN, Paul, BEAU-FALLER, Michèle, MAZIERES, Julien, VALIDIRE, Pierre, GIRARD, Philippe, CAMILLERI-BRÖET, Sophie, VAYLET, Fabien, LEROY-LADURIE, François

“…To identify genetic changes that could drive cancer pathogenesis in never and ever smokers with lung adenocarcinoma. We analyzed the copy number and gene…”
Get full text

Inequity in access to personalized medicine in France: Evidences from analysis of geo variations in the access to molecular profiling among advanced non-small-cell lung cancer patients: Results from the IFCT Biomarkers France Study by Kembou Nzale, Samuel, Weeks, William B, Ouafik, L'Houcine, Rouquette, Isabelle, Beau-Faller, Michèle, Lemoine, Antoinette, Bringuier, Pierre-Paul, Le Coroller Soriano, Anne-Gaëlle, Barlesi, Fabrice, Ventelou, Bruno, d'Onofrio, Alberto

“…In this article, we studied geographic variation in the use of personalized genetic testing for advanced non-small cell lung cancer (NSCLC) and we evaluated…”
Get full text

Clinical outcomes of non-small-cell lung cancer patients with BRAF mutations: results from the French Cooperative Thoracic Intergroup biomarkers France study by Couraud, Sébastien, Barlesi, Fabrice, Fontaine-Deraluelle, Clara, Debieuvre, Didier, Merlio, Jean-Philippe, Moreau, Lionel, Beau-Faller, Michèle, Veillon, Rémi, Mosser, Jean, Al Freijat, Faraj, Bringuier, Pierre-Paul, Léna, Hervé, Ouafik, L'Houcine, Westeel, Virginie, Morel, Alain, Audigier-Valette, Clarisse, Missy, Pascale, Langlais, Alexandra, Morin, Franck, Souquet, Pierre-Jean, Planchard, David

“…Patients with stage IV non-small-cell lung cancer (NSCLC) and BRAF V600 mutations may benefit from targeted therapies. Chemotherapy outcomes are little known…”
Get full text

Specificities of lung adenocarcinoma in women who have never smoked by Mazières, Julien, Rouquette, Isabelle, Lepage, Benoit, Milia, Julie, Brouchet, Laurent, Guibert, Nicolas, Beau-Faller, Michèle, Validire, Pierre, Hofman, Paul, Fouret, Pierre

“…No clear data are available on the high rate of tobacco-independent lung cancer in women. We hypothesize that genetic events or hormonal factors may be partly…”
Get more information

MET gene copy number in non-small cell lung cancer: molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort by Beau-Faller, Michèle, Ruppert, Anne-Marie, Voegeli, Anne-Claire, Neuville, Agnès, Meyer, Nicolas, Guerin, Eric, Legrain, Michèle, Mennecier, Bertrand, Wihlm, Jean-Marie, Massard, Gilbert, Quoix, Elisabeth, Oudet, Pierre, Gaub, Marie P

“…Recent clinical success of epidermal growth factor (EGFR)-tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) have raised hopes that…”
Get more information

The obesity-hypoventilation syndrome revisited: a prospective study of 34 consecutive cases by Kessler, R, Chaouat, A, Schinkewitch, P, Faller, M, Casel, S, Krieger, J, Weitzenblum, E

“…Obesity has many detrimental effects on the respiratory function and may lead to chronic hypoventilation in some patients, an association known as the…”
Get more information

Prognostic Value of Exon 19 Versus 21 EGFR Mutations Varies According to Disease Stage in Surgically Resected Non-small Cell Lung Cancer Adenocarcinoma by Renaud, Stéphane, Seitlinger, Joseph, Guerrera, Francesco, Reeb, Jérémie, Beau-Faller, Michèle, Voegeli, Anne-Claire, Siat, Joelle, Clément-Duchêne, Christelle, Tiotiu, Angelica, Santelmo, Nicola, Costardi, Lorena, Ruffini, Enrico, Falcoz, Pierre-Emmanuel, Vignaud, Jean-Michel, Massard, Gilbert

“…Background The prognostic value of exon 19 and 21 EGFR mutations in stage IV non-small cell lung cancer (NSCLC) is well established. Objective We aimed to…”
Get full text

EGFR tyrosine kinase inhibitors versus chemotherapy in EGFR wild-type pre-treated advanced nonsmall cell lung cancer in daily practice by Tomasini, Pascale, Brosseau, Solenn, Mazières, Julien, Merlio, Jean-Philippe, Beau-Faller, Michèle, Mosser, Jean, Wislez, Marie, Ouafik, L'Houcine, Besse, Benjamin, Rouquette, Isabelle, Debieuvre, Didier, Escande, Fabienne, Westeel, Virginie, Audigier-Valette, Clarisse, Missy, Pascale, Langlais, Alexandra, Morin, Frank, Moro-Sibilot, Denis, Zalcman, Gérard, Barlesi, Fabrice

“…Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are approved for second-line treatment of wild-type ( -wt) nonsmall cell lung cancer…”
Get full text

Genomic aberrations in lung adenocarcinoma in never smokers by Job, Bastien, Bernheim, Alain, Beau-Faller, Michèle, Camilleri-Broët, Sophie, Girard, Philippe, Hofman, Paul, Mazières, Julien, Toujani, Saloua, Lacroix, Ludovic, Laffaire, Julien, Dessen, Philippe, Fouret, Pierre

“…Lung cancer in never smokers would rank as the seventh most common cause of cancer death worldwide. We performed high-resolution array comparative genomic…”
Get full text

An Apoptosis Methylation Prognostic Signature for Early Lung Cancer in the IFCT-0002 Trial by DE FRAIPONT, Florence, LEVALLET, Guénaëlle, DEBIEUVRE, Didier, BRAUN, Denis, WESTEEL, Virginie, QUOIX, Elisabeth, BRAMBILLA, Elisabeth, HAINAUT, Pierre, MORO-SIBILOT, Denis, MORIN, Franck, MILLERON, Bernard, ZALCMAN, Gerard, CREVEUIL, Christian, BERGOT, Emmanuel, BEAU-FALLER, Michele, MOUNAWAR, Mounia, RICHARD, Nicolas, ANTOINE, Martine, ROUQUETTE, Isabelle, FAVROT, Marie-Christine

“…To evaluate prognostic and predictive molecular biomarkers in early-stage non-small cell lung carcinoma (NSCLC) receiving neoadjuvant chemotherapy. The…”
Get full text