Search Results - "Fallatah, Maryam M."

Discovery of compounds that reactivate p53 mutants in vitro and in vivo by Durairaj, Geetha, Demir, Özlem, Lim, Bryant, Baronio, Roberta, Tifrea, Delia, Hall, Linda V, DeForest, Jacob C, Lauinger, Linda, Jebril Fallatah, Maryam M, Yu, Clinton, Bae, Hosung, Lin, Da-Wei, Kim, Jin Kwang, Salehi, Faezeh, Jang, Cholsoon, Qiao, Feng, Lathrop, Richard H, Huang, Lan, Edwards, Robert, Rychnovsky, Scott, Amaro, Rommie E, Kaiser, Peter

“…The tumor suppressor p53 is the most frequently mutated protein in human cancer. The majority of these mutations are missense mutations in the DNA binding…”
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Pyrimidine Triones as Potential Activators of p53 Mutants by Fallatah, Maryam M Jebril, Demir, Özlem, Law, Fiona, Lauinger, Linda, Baronio, Roberta, Hall, Linda, Bournique, Elodie, Srivastava, Ambuj, Metzen, Landon Tyler, Norman, Zane, Buisson, Rémi, Amaro, Rommie E, Kaiser, Peter

“…p53 is a crucial tumor suppressor in vertebrates that is frequently mutated in human cancers. Most mutations are missense mutations that render p53 inactive in…”
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Small-molecule correctors and stabilizers to target p53 by Fallatah, Maryam M.J., Law, Fiona V., Chow, Warren A., Kaiser, Peter

“…The tumor suppressor p53 is among the most attractive precision oncology targets. The two main small-molecule-based approaches for targeting p53 are blocking…”
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Enantiomer of the novel flexible heteroarotinoid, SL-1-09, blocks cell cycle progression in breast cancer cells by Ginn, Emily, Baek, Jihyun, Zou, Hongye, Fallatah, Maryam M.J., Liu, Shengquan, Sevigny, Mary B., Louie, Maggie

“…Flexible heteroarotinoids (Flex-Hets) are compounds with promising anti-cancer activities. SHetA2, a first-generation Flex-Het, has been shown to inhibit the…”
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Novel flexible heteroarotinoid, SL-1-18, promotes ERα degradation to inhibit breast cancer cell growth by Fallatah, Maryam M., Liu, Shengquan, Sevigny, Mary B., Zou, Hongye, Louie, Maggie C.

“…SL-1-18 (1-(chrysen-6-yl)-3-(4-nitrophenyl)thiourea) is new flexible heteroarotinoid (Flex-Het) analog derived from the parent compound, SHetA2, and our…”
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Abstract 113: Evaluating the anticancer activity of two flexible heteroarotinoid analogs on breast cancer by Ginn, Emily, Zou, Hongye, Fallatah, Maryam M., Liu, Shengquan, Louie, Maggie C.

“…Abstract Flexible heteroarotiniods (flex-hets) are compounds derived from retinoic acid and recent studies have indicated that these compounds exhibit…”
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