Search Results - "Fallacara, Anna Lucia"

An Update on JAK Inhibitors by Musumeci, Francesca, Greco, Chiara, Giacchello, Ilaria, Fallacara, Anna Lucia, Ibrahim, Munjed M, Grossi, Giancarlo, Brullo, Chiara, Schenone, Silvia

“…Janus kinases (JAKs) are a family of non-receptor tyrosine kinases, composed by four members, JAK1, JAK2, JAK3 and TYK2. JAKs are involved in different…”
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Pyrrolo[2,3-d]Pyrimidines as Kinase Inhibitors by Musumeci, Francesca, Sanna, Monica, Grossi, Giancarlo, Brullo, Chiara, Fallacara, Anna Lucia, Schenone, Silvia

“…The pyrrolo[2,3-d]pyrimidine nucleus is a deaza-isostere of adenine, the nitrogenous base of ATP, and is present in many ATP-competitive inhibitors of…”
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Optimization of Aminoimidazole Derivatives as Src Family Kinase Inhibitors by Francini, Cinzia Maria, Musumeci, Francesca, Fallacara, Anna Lucia, Botta, Lorenzo, Molinari, Alessio, Artusi, Roberto, Mennuni, Laura, Angelucci, Adriano, Schenone, Silvia

“…Protein kinases have emerged as crucial targets for cancer therapy over the last decades. Since 2001, 40 and 39 kinase inhibitors have been approved by FDA and…”
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The Pyrazolo[3,4- d ]Pyrimidine Derivative Si306 Encapsulated into Anti-GD2-Immunoliposomes as Therapeutic Treatment of Neuroblastoma by Rango, Enrico, Pastorino, Fabio, Brignole, Chiara, Mancini, Arianna, Poggialini, Federica, Di Maria, Salvatore, Zamperini, Claudio, Iovenitti, Giulia, Fallacara, Anna Lucia, Sabetta, Samantha, Clementi, Letizia, Valoti, Massimo, Schenone, Silvia, Angelucci, Adriano, Ponzoni, Mirco, Dreassi, Elena, Botta, Maurizio

“…Si306, a pyrazolo[3,4- ]pyrimidine derivative recently identified as promising anticancer agent, has shown favorable in vitro and in vivo activity profile…”
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Probing the Binding Site of Abl Tyrosine Kinase Using in Situ Click Chemistry by Peruzzotti, Cristina, Borrelli, Stella, Ventura, Micol, Pantano, Rebecca, Fumagalli, Gaia, Christodoulou, Michael S, Monticelli, Damiano, Luzzani, Marcello, Fallacara, Anna Lucia, Tintori, Cristina, Botta, Maurizio, Passarella, Daniele

“…Modern combinatorial chemistry is used to discover compounds with desired function by an alternative strategy, in which the biological target is directly…”
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Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment by Molinari, Alessio, Fallacara, Anna Lucia, Di Maria, Salvatore, Zamperini, Claudio, Poggialini, Federica, Musumeci, Francesca, Schenone, Silvia, Angelucci, Adriano, Colapietro, Alessandro, Crespan, Emmanuele, Kissova, Miroslava, Maga, Giovanni, Botta, Maurizio

“…[Display omitted] •Synthesis of pyrazolo[3,4-d]pyrimidines derivatives endowed with nM Ki values.•Best compound exerted good cytotoxicity activity against…”
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Si113-prodrugs selectively activated by plasmin against hepatocellular and ovarian carcinoma by Rango, Enrico, D'Antona, Lucia, Iovenitti, Giulia, Brai, Annalaura, Mancini, Arianna, Zamperini, Claudio, Trivisani, Claudia Immacolata, Marianelli, Stefano, Fallacara, Anna Lucia, Molinari, Alessio, Cianciusi, Annarita, Schenone, Silvia, Perrotti, Nicola, Dreassi, Elena, Botta, Maurizio

“…Si113, a pyrazolo[3,4-d]pyrimidine derivative, gained more attention as an anticancer agent due to its potent anticancer activity on both in vitro and in vivo…”
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Abstract 2201: Preclinical development of novel pyrazolo[3,4- d ]pyrimidines structure-based TKIs for the treatment of glioblastoma by Mancini, Arianna, Fallacara, Anna Lucia, Zamperini, Claudio, Iovenitti, Giulia, Molinari, Alessio, Rango, Enrico, Angelucci, Adriano, Schenone, Silvia, Botta, Maurizio

“…Abstract The aim of this study was the preclinical development of a set of pyrazolo[3,4-d]pyrimidine structure-based small molecules ATP-competitive SRC…”
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Prodrugs of Pyrazolo[3,4‑d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model by Vignaroli, Giulia, Iovenitti, Giulia, Zamperini, Claudio, Coniglio, Federica, Calandro, Pierpaolo, Molinari, Alessio, Fallacara, Anna Lucia, Sartucci, Andrea, Calgani, Alessia, Colecchia, David, Mancini, Andrea, Festuccia, Claudio, Dreassi, Elena, Valoti, Massimo, Musumeci, Francesca, Chiariello, Mario, Angelucci, Adriano, Botta, Maurizio, Schenone, Silvia

“…Pyrazolo­[3,4-d]­pyrimidines are potent protein kinase inhibitors with promising antitumor activity but suboptimal aqueous solubility, consequently worth being…”
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Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma by Musumeci, Francesca, Fallacara, Anna Lucia, Brullo, Chiara, Grossi, Giancarlo, Botta, Lorenzo, Calandro, Pierpaolo, Chiariello, Mario, Kissova, Miroslava, Crespan, Emmanuele, Maga, Giovanni, Schenone, Silvia

“…In the last few years, several pyrrolo-pyrimidine derivatives have been either approved by the US FDA and in other countries for the treatment of different…”
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Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: Preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line by Fallacara, Anna Lucia, Mancini, Arianna, Zamperini, Claudio, Dreassi, Elena, Marianelli, Stefano, Chiariello, Mario, Pozzi, Gianni, Santoro, Francesco, Botta, Maurizio, Schenone, Silvia

“…[Display omitted] Pyrazolo[3,4-d]pyrimidine derivatives 1–5, active as c-Src inhibitors, have been selected to be formulated as drug-loaded human serum albumin…”
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Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction by D'Agostino, Ilaria, Giacchello, Ilaria, Nannetti, Giulio, Fallacara, Anna Lucia, Deodato, Davide, Musumeci, Francesca, Grossi, Giancarlo, Palù, Giorgio, Cau, Ylenia, Trist, Iuni Margaret, Loregian, Arianna, Schenone, Silvia, Botta, Maurizio

“…The limited treatment options against influenza virus along with the growing public health concerns regarding the continuous emergence of drug-resistant…”
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High-throughput docking for the identification of new influenza A virus polymerase inhibitors targeting the PA-PB1 protein-protein interaction by Tintori, Cristina, Laurenzana, Ilaria, Fallacara, Anna Lucia, Kessler, Ulrich, Pilger, Beatrice, Stergiou, Lilli, Botta, Maurizio

“…A high-throughput molecular docking approach was successfully applied for the selection of potential inhibitors of the Influenza RNA-polymerase which act by…”
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4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA–PB1 Protein–Protein Interaction: Structure–Activity Relationships Exploration with the Aid of Molecular Modeling by Trist, Iuni M. L, Nannetti, Giulio, Tintori, Cristina, Fallacara, Anna Lucia, Deodato, Davide, Mercorelli, Beatrice, Palù, Giorgio, Wijtmans, Maikel, Gospodova, Tzveta, Edink, Ewald, Verheij, Mark, de Esch, Iwan, Viteva, Lilia, Loregian, Arianna, Botta, Maurizio

“…Influenza is an infectious disease that represents an important public health burden, with high impact on the global morbidity, mortality, and economy. The…”
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Combining X‑ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4‑d]pyrimidines as Potent c‑Src Inhibitors Active in Vivo against Neuroblastoma by Tintori, Cristina, Fallacara, Anna Lucia, Radi, Marco, Zamperini, Claudio, Dreassi, Elena, Crespan, Emmanuele, Maga, Giovanni, Schenone, Silvia, Musumeci, Francesca, Brullo, Chiara, Richters, André, Gasparrini, Francesca, Angelucci, Adriano, Festuccia, Claudio, Delle Monache, Simona, Rauh, Daniel, Botta, Maurizio

“…c-Src is a tyrosine kinase belonging to the Src-family kinases. It is overexpressed and/or hyperactivated in a variety of cancer cells, thus its inhibition has…”
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Protein–protein interactions and human cellular cofactors as new targets for HIV therapy by Tintori, Cristina, Brai, Annalaura, Fallacara, Anna Lucia, Fazi, Roberta, Schenone, Silvia, Botta, Maurizio

“…Highlights • Insight into new strategies in HIV therapy. • Targeting protein–protein interactions in HIV. • Targeting cellular cofactors in HIV…”
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Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines by Fallacara, Anna Lucia, Passannanti, Raffaele, Mori, Mattia, Iovenitti, Giulia, Musumeci, Francesca, Greco, Chiara, Crespan, Emmanuele, Kissova, Miroslava, Maga, Giovanni, Tarantelli, Chiara, Spriano, Filippo, Gaudio, Eugenio, Bertoni, Francesco, Botta, Maurizio, Schenone, Silvia

“…Abnormal activation of B-cell receptor (BCR) signaling plays a key role in the development of lymphoid malignancies, and could be reverted by the simultaneous…”
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Insight into the Allosteric Inhibition of Abl Kinase by Fallacara, Anna Lucia, Tintori, Cristina, Radi, Marco, Schenone, Silvia, Botta, Maurizio

“…Abl kinase inhibitors targeting the ATP binding pocket are currently used as a front-line therapy for the treatment of chronic myelogenous leukemia (CML), but…”
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Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors by Musumeci, Francesca, Sanna, Monica, Greco, Chiara, Giacchello, Ilaria, Fallacara, Anna Lucia, Amato, Rosario, Schenone, Silvia

“…Btk is a tyrosine kinase dysregulated in several B-cell malignancies and autoimmune diseases, and this has given rise to a search for Btk inhibitors…”
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A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4- d ]Pyrimidine Dual Src/P-Glycoprotein Inhibitor by Fallacara, Anna Lucia, Zamperini, Claudio, Podolski-Renić, Ana, Dinić, Jelena, Stanković, Tijana, Stepanović, Marija, Mancini, Arianna, Rango, Enrico, Iovenitti, Giulia, Molinari, Alessio, Bugli, Francesca, Sanguinetti, Maurizio, Torelli, Riccardo, Martini, Maurizio, Maccari, Laura, Valoti, Massimo, Dreassi, Elena, Botta, Maurizio, Pešić, Milica, Schenone, Silvia

“…Overexpression of P-glycoprotein (P-gp) and other ATP-binding cassette (ABC) transporters in multidrug resistant (MDR) cancer cells is responsible for the…”
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