Prevalence of therapeutic failure and evolution of biological factors amongst people living with HIV enrolled in antiretroviral therapy at the Ambulatory Treatment Center in Nouakchott, Mauritania

Prevalence of therapeutic failure and evolution of biological factors amongst people living with HIV enrolled in antiretroviral therapy at the Ambulatory Treatment Center in Nouakchott, Mauritania

Goal: The goal of this study is to determine the prevalence of therapeutic failure and the evolution of the biological factors after 6 and 12 months of anti‐retroviral treatment (ART) amongst human immunodefeciency virus (HIV) Patients receiving care through the Ambulatory Treatment Center in Nouakc...

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Bibliographic Details
Published in:Journal of medical virology Vol. 93; no. 6; pp. 3621 - 3626
Main Authors: Ly, Hawa Mariem Ibrahima, Kelly, Mamadou, Fall, Mohamed Vall Mazouzi, Fall‐Malick, F‐Zahra, Kane, Coumba Touré, Lo, Baidy Boubou
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01-06-2021
Subjects:
Ambulatory Treatment Center (ATC) of Nouakchott
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
anti‐retroviral therapy (ART)
biological factors
Biomarkers
Biomonitoring
Blood glucose
Body mass
Body mass index
Body size
Evolution
Hemoglobin
HIV
Human immunodeficiency virus
Immune clearance
Immunology
Mauritania
Patients
Platelets
Telemedicine
therapeutic failure
Transaminase
Virology
Viruses
therapeutic failure
Ambulatory Treatment Center (ATC) of Nouakchott
anti-retroviral therapy (ART)
Mauritania
biological factors
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Summary:Goal: The goal of this study is to determine the prevalence of therapeutic failure and the evolution of the biological factors after 6 and 12 months of anti‐retroviral treatment (ART) amongst human immunodefeciency virus (HIV) Patients receiving care through the Ambulatory Treatment Center in Nouakchott. Methods: The study presents a descriptive and retrospective analysis of 479 patients enrolled in ART between January 2015 and January 2019, with focus on treatment failures and related biomarkers. The average age of the patients studied was 37 ± 12.94 years. The majority (52.8%) were males, of whom (52.6%) were married. Results: The average body mass index (BMI) of the patients progressively increased after 6 and 12 months on ART. The average BMI increased from 20.3 ± 5.1 kg/m2, before treatment, to 21.7 ± 5.0 kg/m2 and 22.7 ± 5.4 kg/m2, after 6 and 12 months of treatment, respectively. Of the 479 patients, 97.3% were on 2 NRTIs + NNRTI. During the first 6 months of treatment, the clinical, immunological, and virological therapeutic failures were 0.6%, 34.10%, and 9%, respectively. After 6 and 12 months of ART, the TCD4, Hemoglobin, platelets, glycemia, creatinemia, and transaminase remained normal during the entire monitoring period. Conclusion: study demonstrated effective HIV treatment amongst the study patients. It showed clearance of virus and immune restoration can be attained after 6 and 12 months of ART. The number of patients who received the tests did decrease during the treatment period, which highlights the importance of adherence to patient management protocols, including clinical and biological monitoring.
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ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.26562