Search Results - "Falkner, Cameron"

Nuclear receptors and nonalcoholic fatty liver disease by Cave, Matthew C, Clair, Heather B, Hardesty, Josiah E, Falkner, K Cameron, Feng, Wenke, Clark, Barbara J, Sidey, Jennifer, Shi, Hongxue, Aqel, Bashar A, McClain, Craig J, Prough, Russell A

“…Nuclear receptors are transcription factors which sense changing environmental or hormonal signals and effect transcriptional changes to regulate core life…”
Get full text

Keratin 18 Is a Diagnostic and Prognostic Factor for Acute Alcoholic Hepatitis by Vatsalya, Vatsalya, Cave, Matthew C., Kong, Maiying, Gobejishvili, Leila, Falkner, K. Cameron, Craycroft, John, Mitchell, Mack, Szabo, Gyongi, McCullough, Arthur, Dasarathy, Srinivasan, Radaeva, Svetlana, Barton, Bruce, McClain, Craig J.

“…Acute alcoholic hepatitis (AAH) is a major cause of liver-related morbidity and mortality; there are no good blood biomarkers for diagnosis or determining…”
Get full text

Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture by Wahlang, Banrida, Falkner, K Cameron, Clair, Heather B, Al-Eryani, Laila, Prough, Russell A, States, J Christopher, Coslo, Denise M, Omiecinski, Curtis J, Cave, Matthew C

“…Polychlorinated biphenyls (PCBs) are persistent environmental toxicants, present in 100% of U.S. adults and dose-dependently associated with obesity and…”
Get full text

Insecticide and metal exposures are associated with a surrogate biomarker for non-alcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003–2004 by Wahlang, Banrida, Appana, Savitri, Falkner, K. Cameron, McClain, Craig J., Brock, Guy, Cave, Matthew C.

“…Non-alcoholic fatty liver disease (NAFLD), the most common form of liver disease, affects over 30% of the US population. Our group and others have previously…”
Get full text

Evaluation of Aroclor 1260 exposure in a mouse model of diet-induced obesity and non-alcoholic fatty liver disease by Wahlang, Banrida, Song, Ming, Beier, Juliane I., Cameron Falkner, K., Al-Eryani, Laila, Clair, Heather B., Prough, Russell A., Osborne, Tanasa S., Malarkey, David E., States, J. Christopher, Cave, Matthew C.

“…Polychlorinated biphenyls (PCBs) are persistent organic pollutants associated with non-alcoholic fatty liver disease (NAFLD) in epidemiologic studies. The…”
Get full text

Toxicant‐associated steatohepatitis in vinyl chloride workers by Cave, Matt, Falkner, Keith Cameron, Ray, Mukunda, Joshi‐Barve, Swati, Brock, Guy, Khan, Rehan, Bon Homme, Marjorie, McClain, Craig J.

“…Although nonalcoholic steatohepatitis (NASH) is typically associated with obesity, it has also been reported to occur in lean individuals exposed to industrial…”
Get full text

Polychlorinated Biphenyl-Xenobiotic Nuclear Receptor Interactions Regulate Energy Metabolism, Behavior, and Inflammation in Non-alcoholic-Steatohepatitis by Wahlang, Banrida, Prough, Russell A, Falkner, K Cameron, Hardesty, Josiah E, Song, Ming, Clair, Heather B, Clark, Barbara J, States, J Christopher, Arteel, Gavin E, Cave, Matthew C

“…Polychlorinated biphenyls (PCBs) are environmental pollutants associated with non-alcoholic-steatohepatitis (NASH), diabetes, and obesity. We previously…”
Get full text

Dioxin-like and non-dioxin-like PCBs differentially regulate the hepatic proteome and modify diet-induced nonalcoholic fatty liver disease severity by Jin, Jian, Wahlang, Banrida, Shi, Hongxue, Hardesty, Josiah E., Falkner, K. Cameron, Head, Kimberly Z., Srivastava, Sudhir, Merchant, Michael L., Rai, Shesh N., Cave, Matthew C., Prough, Russell A.

“…Polychlorinated biphenyls (PCBs) are persistent organic pollutants associated with metabolic disruption and nonalcoholic fatty liver disease (NAFLD). Based on…”
Get full text

Olanzapine activates hepatic mammalian target of rapamycin: new mechanistic insight into metabolic dysregulation with atypical antipsychotic drugs by Schmidt, Robin H, Jokinen, Jenny D, Massey, Veronica L, Falkner, K Cameron, Shi, Xue, Yin, Xinmin, Zhang, Xiang, Beier, Juliane I, Arteel, Gavin E

“…Olanzapine (OLZ), an effective treatment of schizophrenia and other disorders, causes weight gain and metabolic syndrome. Most studies to date have focused on…”
Get more information

Concentration dependence of human and mouse aryl hydrocarbon receptor responsiveness to polychlorinated biphenyl exposures: Implications for aroclor mixtures by Shi, Hongxue, Hardesty, Josiah E., Jin, Jian, Head, Kimberly Z., Falkner, K. Cameron, Cave, Matthew C., Prough, Russell Allen

“…1. Aryl hydrocarbon receptor (AhR) ligands, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs), are endocrine disrupting…”
Get full text

Metabolomic Analysis of the Effects of Polychlorinated Biphenyls in Nonalcoholic Fatty Liver Disease by Shi, Xue, Wahlang, Banrida, Wei, Xiaoli, Yin, Xinmin, Falkner, K. Cameron, Prough, Russell A, Kim, Seong Ho, Mueller, Eugene G, McClain, Craig J, Cave, Matthew, Zhang, Xiang

“…Polychlorinated biphenyls (PCBs) are persistent organic pollutants and have been associated with abnormal liver enzymes and suspected nonalcoholic fatty liver…”
Get full text

Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice by Wahlang, Banrida, Falkner, K. Cameron, Gregory, Bonnie, Ansert, Douglas, Young, David, Conklin, Daniel J, Bhatnagar, Aruni, McClain, Craig J, Cave, Matt

“…Polychlorinated biphenyls (PCBs) are persistent environmental pollutants that are detectable in the serum of all American adults. Amongst PCB congeners, PCB…”
Get full text

Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Implications for nonalcoholic steatohepatitis and diabetes by Shi, Hongxue, Jan, Jian, Hardesty, Josiah E., Falkner, K. Cameron, Prough, Russell A., Balamurugan, Appakalai N., Mokshagundam, Sri Prakash, Chari, Suresh T., Cave, Matthew C.

“…The endocrine disrupting chemicals, polychlorinated biphenyls (PCBs), have been associated with nonalcoholic steatohepatitis (NASH) and diabetes. However, an…”
Get full text

Liver Injury and Endotoxemia in Male and Female Alcohol‐Dependent Individuals Admitted to an Alcohol Treatment Program by Kirpich, Irina A., McClain, Craig J., Vatsalya, Vatsalya, Schwandt, Melanie, Phillips, Monte, Falkner, Keith Cameron, Zhang, Lucy, Harwell, Catey, George, David T., Umhau, John C.

“…Background Interactions between the liver, the gut, and the immune system are critical components of alcoholic liver disease (ALD). The aim of this study was…”
Get full text

Serum Cytokeratin 18 and Cytokine Elevations Suggest A High Prevalence of Occupational Liver Disease in Highly Exposed Elastomer/Polymer Workers by Cave, Matt, Falkner, Keith Cameron, Henry, Latasha, Costello, Brittany, Gregory, Bonnie, McClain, Craig J.

“…Objective: Cytokeratin 18 (CK18) is a novel serologic biomarker for occupational liver disease. The purpose of this study is to determine the prevalence of…”
Get full text

Regulation of the Rat Glutathione S-Transferase A2 Gene by Glucocorticoids: Crosstalk Through C EBPs by Cameron Falkner, K., Prough, Russell A.

“…Regulation of the rat glutathione S-transferase A2 (GSTA2) gene by glucocorticoids is biphasic in its concentration dependence to glucocorticoids, with…”
Get full text

Toxicant-associated Steatohepatitis by Wahlang, Banrida, Beier, Juliane I., Clair, Heather B., Bellis-Jones, Heather J., Falkner, K. Cameron, McClain, Craig J., Cave, Matt C.

“…Hepatotoxicity is the most common organ injury due to occupational and environmental exposures to industrial chemicals. A wide range of liver pathologies…”
Get full text

Mechanisms of Environmental Contributions to Fatty Liver Disease by Wahlang, Banrida, Jin, Jian, Beier, Juliane I., Hardesty, Josiah E., Daly, Erica F., Schnegelberger, Regina D., Falkner, K. Cameron, Prough, Russell A., Kirpich, Irina A, Cave, Matthew C.

“…Purpose Fatty liver disease (FLD) affects over 25% of the global population and may lead to liver-related mortality due to cirrhosis and liver cancer. FLD…”
Get full text

Identifying sex differences arising from polychlorinated biphenyl exposures in toxicant-associated liver disease by Wahlang, Banrida, Jin, Jian, Hardesty, Josiah E., Head, Kimberly Z., Shi, Hongxue, Falkner, K. Cameron, Prough, Russell A., Klinge, Carolyn M., Cave, Matthew C.

“…Exposures to persistent environmental pollutants like polychlorinated biphenyls (PCBs) has been associated with liver diseases such as toxicant-associated…”
Get full text

Epidermal Growth Factor Receptor Signaling Disruption by Endocrine and Metabolic Disrupting Chemicals by Hardesty, Josiah E, Al-Eryani, Laila, Wahlang, Banrida, Falkner, K Cameron, Shi, Hongxue, Jin, Jian, Vivace, Brad J, Ceresa, Brian P, Prough, Russell A, Cave, Matthew C

“…Abstract The purpose of this study is to identify an environmentally relevant shared receptor target for endocrine and metabolism disrupting chemical…”
Get full text