Search Results - "Falkenhagen, Alexander"

Colon-derived Caco-2 cells support replication of hepatitis E virus genotype 1 strain Sar55 generated by reverse genetics by Falkenhagen, Alexander, Panajotov, Jessica, Johne, Reimar

“…•Lack of efficient HEV-1 cell culture systems hinders research.•Comparison of revere genetics approaches for the generation of HEV-1 and HEV-3.•HEV-1 strain…”
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Molecularly generated rat hepatitis E virus strains from human and rat show efficient replication in a human hepatoma cell line by Panajotov, Jessica, Falkenhagen, Alexander, Gadicherla, Ashish K., Johne, Reimar

“…•Infectious ratHEV was generated based on sequence data of a human patient strain.•Comparison with HEV-GT3 and rat-derived ratHEV replication in different cell…”
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Genetic Strategies for HIV Treatment and Prevention by Falkenhagen, Alexander, Joshi, Sadhna

“…Conventional HIV gene therapy approaches are based on engineering HIV target cells that are non-permissive to viral replication. However, expansion of…”
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VP4 Mutation Boosts Replication of Recombinant Human/Simian Rotavirus in Cell Culture by Valusenko-Mehrkens, Roman, Schilling-Loeffler, Katja, Johne, Reimar, Falkenhagen, Alexander

“…Rotavirus A (RVA) is the leading cause of diarrhea requiring hospitalization in children and causes over 100,000 annual deaths in Sub-Saharan Africa. In order…”
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Distantly Related Rotaviruses in Common Shrews, Germany, 2004-2014 by Johne, Reimar, Tausch, Simon H, Grützke, Josephine, Falkenhagen, Alexander, Patzina-Mehling, Corinna, Beer, Martin, Höper, Dirk, Ulrich, Rainer G

“…We screened samples from common shrews (Sorex araneus) collected in Germany during 2004-2014 and identified 3 genetically divergent rotaviruses. Virus protein…”
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The Translated Amino Acid Sequence of an Insertion in the Hepatitis E Virus Strain 47832c Genome, But Not the RNA Sequence, Is Essential for Efficient Cell Culture Replication by Scholz, Johannes, Falkenhagen, Alexander, Johne, Reimar

“…The hepatitis E virus (HEV) can cause hepatitis E in humans. Recently, the occurrence of HEV strains carrying insertions in their hypervariable genome region…”
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Strain-Specific Interactions between the Viral Capsid Proteins VP4, VP7 and VP6 Influence Rescue of Rotavirus Reassortants by Reverse Genetics by Valusenko-Mehrkens, Roman, Gadicherla, Ashish K, Johne, Reimar, Falkenhagen, Alexander

“…(RVA) genome segments can reassort upon co-infection of target cells with two different RVA strains. However, not all reassortants are viable, which limits the…”
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Potential of avian and mammalian species A rotaviruses to reassort as explored by plasmid only-based reverse genetics by Patzina-Mehling, Corinna, Falkenhagen, Alexander, Trojnar, Eva, Gadicherla, Ashish K., Johne, Reimar

“…•Cloning of all 11 genome segments of avian rotavirus A strain 02V0002G3 into plasmids•Transfection of the plasmids into cells did not lead to generation of…”
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HIV Entry and Its Inhibition by Bifunctional Antiviral Proteins by Falkenhagen, Alexander, Joshi, Sadhna

“…HIV entry is a highly specific and time-sensitive process that can be divided into receptor binding, coreceptor binding, and membrane fusion. Bifunctional…”
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Rescue of Infectious Rotavirus Reassortants by a Reverse Genetics System Is Restricted by the Receptor-Binding Region of VP4 by Falkenhagen, Alexander, Huyzers, Marno, van Dijk, Alberdina A, Johne, Reimar

“…The rotavirus species A (RVA) capsid contains the spike protein VP4, which interacts with VP6 and VP7 and is involved in cellular receptor binding. The capsid…”
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Generation of Simian Rotavirus Reassortants with VP4- and VP7-Encoding Genome Segments from Human Strains Circulating in Africa Using Reverse Genetics by Falkenhagen, Alexander, Patzina-Mehling, Corinna, Gadicherla, Ashish K, Strydom, Amy, O'Neill, Hester G, Johne, Reimar

“…Human rotavirus A (RVA) causes acute gastroenteritis in infants and young children. The broad use of two vaccines, which are based on RVA strains from Europe…”
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Further Characterization of the Bifunctional HIV Entry Inhibitor sCD4-FIT45 by Falkenhagen, Alexander, Joshi, Sadhna

“…HIV entry into target cells is a highly sequential and time-sensitive process. In recent years, potent HIV Env-targeting antibodies, such as VRC01, have been…”
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Control of HIV Infection In Vivo Using Gene Therapy with a Secreted Entry Inhibitor by Falkenhagen, Alexander, Singh, Jastaranpreet, Asad, Sabah, Leontyev, Danila, Read, Stanley, Zúñiga-Pflücker, Juan Carlos, Joshi, Sadhna

“…HIV entry inhibitors are highly effective in controlling virus replication. We have developed a lentiviral vector that expresses a secreted entry inhibitor,…”
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Establishment of a Plasmid-Based Reverse Genetics System for the Cell Culture-Adapted Hepatitis E Virus Genotype 3c Strain 47832c by Scholz, Johannes, Bächlein, Christine, Gadicherla, Ashish K, Falkenhagen, Alexander, Tausch, Simon H, Johne, Reimar

“…The hepatitis E virus (HEV) causes acute and chronic hepatitis in humans. Investigation of HEV replication is hampered by the lack of broadly applicable,…”
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Short hairpin-loop-structured oligodeoxynucleotides reduce HSV-1 replication by Falkenhagen, Alexander, Heinrich, Jochen, Moelling, Karin

“…The Herpes simplex virus (HSV) is known as an infectious agent and widespread in the human population. The symptoms of HSV infections can range from mild to…”
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Heat stability of foodborne viruses – Findings, methodological challenges and current developments by Johne, Reimar, Scholz, Johannes, Falkenhagen, Alexander

“…Heat treatment of food represents an important measure to prevent pathogen transmission. Thus far, evaluation of heat treatment processes is mainly based on…”
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Coronaviruses are stable on glass, but are eliminated by manual dishwashing procedures by Schilling-Loeffler, Katja, Falkenhagen, Alexander, Johne, Reimar

“…Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is primarily transmitted from human to human via droplets and aerosols. While transmission…”
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Hepatitis E virus-a zoonotic virus: distribution, transmission pathways, and relevance for food safety by Johne, Reimar, Althof, Nadine, Nöckler, Karsten, Falkenhagen, Alexander

“…The hepatitis E virus (HEV) is an etiological agent of acute hepatitis in humans. In addition, chronic infections resulting in fatal liver cirrhosis currently…”
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Further Characterization of the Bifunctional HIV Entry Inhibitor sCD4-FI T45 by Falkenhagen, Alexander, Joshi, Sadhna

“…HIV entry into target cells is a highly sequential and time-sensitive process. In recent years, potent HIV Env-targeting antibodies, such as VRC01, have been…”
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Generation of simian rotavirus reassortants with diverse VP4 genes using reverse genetics by Falkenhagen, Alexander, Patzina-Mehling, Corinna, Rückner, Antje, Vahlenkamp, Thomas W, Johne, Reimar

“…Species A rotaviruses (RVAs) are a major cause of gastroenteritis in animals and humans. Their genome consists of 11 segments of dsRNA, and reassortment events…”
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