Search Results - "Falkenburg, JH"

SARS-CoV-2-specific CD4 + and CD8 + T cell responses can originate from cross-reactive CMV-specific T cells by Pothast, Cilia R, Dijkland, Romy C, Thaler, Melissa, Hagedoorn, Renate S, Kester, Michel G D, Wouters, Anne K, Hiemstra, Pieter S, van Hemert, Martijn J, Gras, Stephanie, Falkenburg, J H Frederik, Heemskerk, Mirjam H M

“…Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific CD4 and CD8 T cells in SARS-CoV-2-unexposed donors has been explained by the…”
Get full text

PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy by Luk, Sietse J, Steen, Dirk M van der, Hagedoorn, Renate S, Jordanova, Ekaterina S, Schilham, Marco W, Bovée, Judith VMG, Cleven, Arjen HG, Falkenburg, JH Frederik, Szuhai, Karoly, Heemskerk, Mirjam HM

“…Synovial sarcoma expresses multiple cancer testis antigens that could potentially be targeted by T-cell receptor (TCR) gene therapy. In this study we…”
Get full text

Intentional donor lymphocyte-induced limited acute graft-versus-host disease is essential for long-term survival of relapsed acute myeloid leukemia after allogeneic stem cell transplantation by Eefting, Matthias, von dem Borne, Peter A, de Wreede, Liesbeth C, Halkes, Constantijn J M, Kersting, Sabina, Marijt, Erik W A, Veelken, Hendrik, Falkenburg, Jh Frederik

“…The prognosis of patients with relapsed acute myeloid leukemia after allogeneic transplantation is poor. We hypothesized that initial disease control by…”
Get full text

A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells by Luimstra, Jolien J, Garstka, Malgorzata A, Roex, Marthe C J, Redeker, Anke, Janssen, George M C, van Veelen, Peter A, Arens, Ramon, Falkenburg, J H Frederik, Neefjes, Jacques, Ovaa, Huib

“…Adaptive immunity is initiated by T cell recognition of specific antigens presented by major histocompatibility complexes (MHCs). MHC multimer technology has…”
Get full text

Monocyte-derived dendritic cells can induce autoreactive CD4 super(+) T cells showing myeloid lineage directed reactivity in healthy individuals by Lam, Tin Sing, Meent, Marian, Falkenburg, JH Frederik, Jedema, Inge

“…T cells against self-antigens can be detected in peripheral blood of healthy individuals, although intrathymic negative selection removes most high-avidity T…”
Get full text

GNB1 K89M Drives TKI Resistance in ETV6-ABL1-Positive Leukemia by Zimmermannova, Olga, Doktorova, Eliska, Stuchly, Jan, Alberich Jorda, Meritxell, Petrak, Jiri, Falkenburg, JH Frederik, Starkova, Julia, Trka, Jan, Zuna, Jan, Zaliova, Marketa

“…Leukemias harboring ETV6-ABL1 fusion represent a rare prognostically unfavorable subgroup of hematological malignancies. To a great extent they share…”
Get full text

Monocyte‐derived dendritic cells can induce autoreactive CD4+ T cells showing myeloid lineage directed reactivity in healthy individuals by Lam, Tin Sing, Meent, Marian, Falkenburg, JH Frederik, Jedema, Inge

“…T cells against self‐antigens can be detected in peripheral blood of healthy individuals, although intrathymic negative selection removes most high‐avidity T…”
Get full text

Modeling Resistance To Tyrosine Kinase Inhibitors In TEL/ABL-Positive Acute Lymphoblastic Leukemia by Zimmermannova, Olga, Zuna, Jan, Polakova, Katerina Machova, Lizcova, Libuse, Zemanova, Zuzana, Chen, I-Ming L., Falkenburg, JH Frederik, Harvey, Richard C., Willman, Cheryl L., Trka, Jan, Zaliova, Marketa

“…TEL/ABL-positive (TEL/ABL+) acute lymphoblastic leukemia (ALL) is a very rare prognostically unfavorable disease. Its pathogenesis is similar to the…”
Get full text

Interleukin 1 Induces Human Marrow Stromal Cells in Long-Term Culture to Produce Granulocyte Colony-Stimulating Factor and Macrophage Colony-Stimulating Factor by Fibbe, Willem E., Damme, Jo van, Billiau, Alfons, Goselink, Henrietta M., Voogt, Paul J., Eeden, Gerda van, Ralph, Peter, Altrock, Bruce W., Falkenburg, J.H. Frederik

“…Pure interleukin 1 (IL 1) was found to stimulate established human bone marrow stromal layers in long-term culture to produce colony-stimulating activity…”
Get full text

Human Fibroblasts Produce Granulocyte-CSF, Macrophage-CSF, and Granulocyte-Macrophage-CSF Following Stimulation by Interleukin-1 and Poly(rI).Poly(rC) by Fibbe, Willem E., Damme, Jo Van, Billiau, Alfons, Duinkerken, Nelleke, Lurvink, Elly, Ralph, Peter, Altrock, Bruce W., Kaushansky, Kenneth, Willemze, Roel, Falkenburg, J.H. Frederik

“…Electrophoretically pure human interleukin-1 (IL-1) beta was found to stimulate human fibroblasts in a monolayer culture to elaborate colony-stimulating…”
Get full text

Reduced-intensity conditioning allogeneic stem cell transplantation with donor T-cell depletion using alemtuzumab added to the graft (‘Campath in the bag’) by von dem Borne, Peter A, Ingrid Starrenburg, CWJ, Halkes, Stijn JM, Erik Marijt, WA, Fibbe, Willem E, Frederik Falkenburg, JH, Willemze, Roel

“…Reduced-intensity conditioning (RIC) has allowed the use of allogeneic stem cell transplantation (alloSCT) for haematological malignancies in elderly patients…”
Get full text

The mechanisms of Ara-C-induced apoptosis of resting B-chronic lymphocytic leukemia cells by de Vries, JF, Falkenburg, JH, Willemze, R, Barge, RM

“…Department of Hematology, Leiden University Medical Center, P.O. Box 9600 2300 RC Leiden, The Netherlands. j.f.vries@lumc.nl BACKGROUND AND OBJECTIVES:…”
Get full text

Identification of Varicella-Zoster Virus-Specific CD8 T Cells in Patients after T-Cell-Depleted Allogeneic Stem Cell Transplantation by VAN DER HEIDEN, Pim L. J, DE BOER, Renate, WILLEMZE, Roel, FALKENBURG, J. H. Frederik, HEEMSKERK, Mirjam H. M, VAN DER STEEN, Dirk M, KESTER, Michel G. D, VAN DER HOORN, Menno W. A. G, HAARMAN, Wilmy M. E, BARNBY-PORRITT, Helen E, FRY, Jeremy W, NAPPER, C. E, MARIJT, Erik W. A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Interleukin-1 (22-K Factor) Induces Release of Granulocyte-Macrophage Colony-Stimulating Activity From Human Mononuclear Phagocytes by Fibbe, Willem E., Damme, Jo van, Billiau, Alfons, Voogt, Paul J., Duinkerken, Nelleke, Kluck, Petra M.C., Falkenburg, J.H. Frederik

“…An electrophoretically pure preparation of natural human interleukin-1 (IL-1) was shown to stimulate in vitro colony formation in human bone marrow cultures…”
Get full text

Efficient Activation of LRH-1―specific CD8+ T-cell Responses From Transplanted Leukemia Patients by Stimulation With P2X5 mRNA-electroporated Dendritic Cells by OVERES, Ingrid M, FREDRIX, Hanny, KESTER, Michel G. D, FREDERIK FALKENBURG, J. H, VAN DER VOORT, Robbert, DE WITTE, Theo M, DOLSTRA, Harry

“…Alloreactive CD8+ T cells targeting minor histocompatibility antigens (MiHA) on malignant cells of the recipient play a pivotal role in graft-versus-tumor…”
Get full text

Outcomes after myeloablative unrelated donor stem cell transplantation using both in vitro and in vivo T-cell depletion with alemtuzumab by von dem Borne, PA, Beaumont, F, Starrenburg, CW, Oudshoorn, M, Hale, G, Falkenburg, JH, Fibbe, WE, Willemze, R, Barge, RM

“…Dept. of Hematology, Leiden University Medical Center, Leiden, The Netherlands. P.A.von_dem_Borne@lumc.nl HLA-matched unrelated donor (MUD) stem cell…”
Get full text

Generation of CD4+ cytotoxic T-lymphocyte clones from a patient with severe graft-versus-host disease after allogeneic bone marrow transplantation : implications for graft-versus-leukemia reactivity by FABER, L. M, VAN LUXEMBURG-HEIJS, S. A. P, VEENHOF, W. F. J, WILLEMZE, R, FALKENBURG, J. H. F

“…HLA-identical bone marrow transplantation (BMT) is associated with both graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) reactivity. Different…”
Get full text

Characterization of the human CD34+ hematopoietic progenitor cell compartment during the second trimester of pregnancy by Lim, FT, Kanhai, HH, Falkenburg, JH

“…Department of Hematology, Leiden University Medical Center, The Netherlands. f.lim@leyenburg-ziekenhuis.nl BACKGROUND AND OBJECTIVES: Characterization of the…”
Get full text

Proteosomal degradation of BCR/ABL protein can generate an HLA-A0301-restricted peptide, but high-avidity T cells recognizing this leukemia-specific antigen were not demonstrated by Posthuma, EF, van Bergen, CA, Kester, MG, de Paus, RA, van Veelen, PA, de Ru, AH, Drijfhout, JW, Lurvink, EG, Willemze, R, Falkenburg, JH

“…Dept. of Hematology, Leiden, University Medical Center, PO Box 9600, 2300 RC, The Netherlands. posthuma@rdgg.nl BACKGROUND AND OBJECTIVES: Cytotoxic…”
Get full text

Recognition of minor histocompatibility antigens on lymphocytic and myeloid leukemic cells by cytotoxic T-cell clones by VAN DER HARST, D, GOULMY, E, FALKENBURG, J. H. F, KOOIJ-WINKELAAR, Y. M. C, VAN LUXEMBURG-HEIJS, S. A. P, GOSELINK, H. M, BRAND, A

“…Clinical studies indicated an enhanced antileukemic effect of allogeneic bone marrow transplantation (BMT), as compared with autologous BMT. After allogeneic…”
Get full text