Search Results - "Falk W. Lohoff"

Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study by Rosoff, Daniel B, Davey Smith, George, Mehta, Nehal, Clarke, Toni-Kim, Lohoff, Falk W

“…Alcohol consumption and smoking, 2 major risk factors for cardiovascular disease (CVD), often occur together. The objective of this study is to use a wide…”
Get full text

Targeting Unmet Clinical Needs in the Treatment of Alcohol Use Disorder by Lohoff, Falk W.

“…Alcohol Use Disorder (AUD) is a chronic psychiatric disorder marked by impaired control over drinking behavior that poses a significant challenge to the…”
Get full text

Random forest based classification of alcohol dependence patients and healthy controls using resting state MRI by Zhu, Xi, Du, Xiaofei, Kerich, Mike, Lohoff, Falk W., Momenan, Reza

“…•Diagnosis of alcohol use disorder using resting state functional connectivity.•Quantify resting-state within-network and between-network connectivity features…”
Get full text

Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Cognitive Function by Rosoff, Daniel B., Bell, Andrew S., Jung, Jeesun, Wagner, Josephin, Mavromatis, Lucas A., Lohoff, Falk W.

“…Lipid-lowering therapy with statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition are effective strategies in reducing cardiovascular…”
Get full text

Overview of the Genetics of Alcohol Use Disorder by Tawa, Elisabeth A, Hall, Samuel D, Lohoff, Falk W

“…Alcohol Use Disorder (AUD) is a chronic psychiatric illness characterized by harmful drinking patterns leading to negative emotional, physical, and social…”
Get full text

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in the Brain and Relevance for Neuropsychiatric Disorders by O'Connell, Emma M, Lohoff, Falk W

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) has long been studied in the liver due to its regulation of plasma low-density lipoprotein cholesterol…”
Get full text

Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2 by Luo, Audrey, Jung, Jeesun, Longley, Martha, Rosoff, Daniel B, Charlet, Katrin, Muench, Christine, Lee, Jisoo, Hodgkinson, Colin A, Goldman, David, Horvath, Steve, Kaminsky, Zachary A, Lohoff, Falk W

“…To investigate the potential role of alcohol use disorder (AUD) in aging processes, we employed Levine's epigenetic clock (DNAm PhenoAge) to estimate DNA…”
Get full text

Multi-omic underpinnings of epigenetic aging and human longevity by Mavromatis, Lucas A., Rosoff, Daniel B., Bell, Andrew S., Jung, Jeesun, Wagner, Josephin, Lohoff, Falk W.

“…Biological aging is accompanied by increasing morbidity, mortality, and healthcare costs; however, its molecular mechanisms are poorly understood. Here, we use…”
Get full text

DNA methylation age is accelerated in alcohol dependence by Rosen, Allison D., Robertson, Keith D., Hlady, Ryan A., Muench, Christine, Lee, Jisoo, Philibert, Robert, Horvath, Steve, Kaminsky, Zachary A., Lohoff, Falk W.

“…Alcohol dependence (ALC) is a chronic, relapsing disorder that increases the burden of chronic disease and significantly contributes to numerous premature…”
Get full text

Double dissociation of dopamine genes and timing in humans by Wiener, Martin, Lohoff, Falk W, Coslett, H Branch

“…A number of lines of evidence implicate dopamine in timing [Rammsayer, T. H. Neuropharmacological approaches to human timing. In S. Grondin (Ed.), Psychology…”
Get more information

Smoking is significantly associated with increased risk of COVID-19 and other respiratory infections by Rosoff, Daniel B., Yoo, Joyce, Lohoff, Falk W.

“…Observational studies suggest smoking, cannabis use, alcohol consumption, and substance use disorders (SUDs) may impact risk for respiratory infections,…”
Get full text

Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1) gene affects dopamine signaling by Lohoff, Falk W., Carr, Gregory V., Brookshire, Bethany, Ferraro, Thomas N., Lucki, Irwin

“…•VMAT1 has recently been identified as target for neuropsychiatric disorders.•This study investigated null-mutant VMAT1 animals for effects on monoamine…”
Get full text

Individual differences in the morphometry and activation of time perception networks are influenced by dopamine genotype by Wiener, Martin, Lee, Yune-Sang, Lohoff, Falk W., Coslett, H. Branch

“…Individual participants vary greatly in their ability to estimate and discriminate intervals of time. This heterogeneity of performance may be caused by…”
Get full text

Comparing the Relationships of Genetically Proxied PCSK9 Inhibition With Mood Disorders, Cognition, and Dementia Between Men and Women: A Drug-Target Mendelian Randomization Study by Bell, Andrew S, Rosoff, Daniel B, Mavromatis, Lucas A, Jung, Jeesun, Wagner, Josephin, Lohoff, Falk W

“…Background PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors are important therapeutic options for reducing cardiovascular disease risk;…”
Get full text

Variability in cTBS Aftereffects Attributed to the Interaction of Stimulus Intensity With BDNF Val66Met Polymorphism by Harvey, Denise Y., DeLoretta, Laura, Shah-Basak, Priyanka P., Wurzman, Rachel, Sacchetti, Daniela, Ahmed, Ahmed, Thiam, Abdou, Lohoff, Falk W., Faseyitan, Olufunsho, Hamilton, Roy H.

“…Objective : To evaluate whether a common polymorphism (Val66Met) in the gene for brain-derived neurotrophic factor (BDNF)—a gene thought to influence…”
Get full text

Prescription Opioid Use and Risk for Major Depressive Disorder and Anxiety and Stress-Related Disorders: A Multivariable Mendelian Randomization Analysis by Rosoff, Daniel B, Smith, George Davey, Lohoff, Falk W

“…Growing evidence suggests that prescription opioid use affects depression and anxiety disorders; however, observational studies are subject to confounding,…”
Get more information

COMT and ANKK1-Taq-Ia genetic polymorphisms influence visual working memory by Berryhill, Marian E, Wiener, Martin, Stephens, Jaclyn A, Lohoff, Falk W, Coslett, H Branch

“…Complex cognitive tasks such as visual working memory (WM) involve networks of interacting brain regions. Several neurotransmitters, including an appropriate…”
Get full text

Genetic Variation in the Vesicular Monoamine Transporter 1 (VMAT1/SLC18A1) Gene and Alcohol Withdrawal Severity by Dutta, Nisha, Helton, Sarah G., Schwandt, Melanie, Zhu, Xi, Momenan, Reza, Lohoff, Falk W.

“…Background Alcohol withdrawal (AW) can be a serious consequence of alcohol dependence and consists of various neurochemical adaptations in the brain. One such…”
Get full text

Overview of the Genetics of Major Depressive Disorder by Lohoff, Falk W.

“…Major depressive disorder (MDD) is a common psychiatric illness with high levels of morbidity and mortality. Despite intensive research during the past several…”
Get full text

Pharmacotherapies and personalized medicine for alcohol use disorder: a review by Lohoff, Falk W

“…Alcohol use disorder (AUD) is highly prevalent and among the leading causes of morbidity and mortality in the United States. Pharmacotherapies for AUD are…”
Get full text