Search Results - "Falk, Ben A."

Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis by Nagy, Nadine, Kaber, Gernot, Johnson, Pamela Y, Gebe, John A, Preisinger, Anton, Falk, Ben A, Sunkari, Vivekananda G, Gooden, Michel D, Vernon, Robert B, Bogdani, Marika, Kuipers, Hedwich F, Day, Anthony J, Campbell, Daniel J, Wight, Thomas N, Bollyky, Paul L

“…We recently reported that abundant deposits of the extracellular matrix polysaccharide hyaluronan (HA) are characteristic of autoimmune insulitis in patients…”
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Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue by Martinez, Hunter A., Koliesnik, Ievgen, Kaber, Gernot, Reid, Jacqueline K., Nagy, Nadine, Barlow, Graham, Falk, Ben A., Medina, Carlos O., Hargil, Aviv, Zihsler, Svenja, Vlodavsky, Israel, Li, Jin-Ping, Pérez-Cruz, Magdiel, Tang, Sai-Wen, Meyer, Everett H., Wrenshall, Lucile E., Lord, James D., Garcia, K. Christopher, Palmer, Theo D., Steinman, Lawrence, Nepom, Gerald T., Wight, Thomas N., Bollyky, Paul L., Kuipers, Hedwich F.

“…Although FOXP3 + regulatory T cells (Treg) depend on IL-2 produced by other cells for their survival and function, the levels of IL-2 in inflamed tissue are…”
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ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors by Bollyky, Paul L., Wu, Rebecca P., Falk, Ben A., Lord, James D., Long, S. Alice, Preisinger, Anton, Teng, Brandon, Holt, Gregory E., Standifer, Nathan E., Braun, Kathleen R., Xie, Cindy Fang, Samuels, Peter L., Vernon, Robert B., Gebe, John A., Wight, Thomas N., Nepom, Gerald T., Germain, Ron

“…We describe a role for ECM as a biosensor for inflammatory microenvironments that plays a critical role in peripheral immune tolerance. We show that hyaluronan…”
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Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells by Bollyky, Paul L., Falk, Ben A., Wu, Rebecca P., Buckner, Jane H., Wight, Thomas N., Nepom, Gerald T.

“…The authors describe the immunoregulatory contributions of intact versus fragmented hyaluronan, a prominent component of the extracellular matrix. The…”
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Modified High-Molecular-Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance by Gebe, John A, Yadava, Koshika, Ruppert, Shannon M, Marshall, Payton, Hill, Paul, Falk, Ben A, Sweere, Johanna M, Han, Hongwei, Kaber, Gernot, Harten, Ingrid A, Medina, Carlos, Mikecz, Katalin, Ziegler, Steven F, Balaji, Swathi, Keswani, Sundeep G, Perez, Vinicio A de Jesus, Butte, Manish J, Nadeau, Kari, Altemeier, William A, Fanger, Neil, Bollyky, Paul L

“…The extracellular matrix in asthmatic lungs contains abundant low-molecular-weight hyaluronan, and this is known to promote antigen presentation and allergic…”
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Nanocarrier-enhanced intracellular delivery of benznidazole for treatment of Trypanosoma cruzi infection by Li, Xiaomo, Yi, Sijia, Scariot, Débora B, Martinez, Santiago J, Falk, Ben A, Olson, Cheryl L, Romano, Patricia S, Scott, Evan A, Engman, David M

“…Chagas disease is caused by infection with the protozoan parasite Trypanosoma cruzi (T. cruzi), an intracellular pathogen that causes significant morbidity and…”
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Trypanosoma brucei Acyl-Protein Thioesterase-like (TbAPT-L) Is a Lipase with Esterase Activity for Short and Medium-Chain Fatty Acids but Has No Depalmitoylation Activity by Brown, Robert W B, Sharma, Aabha I, Villanueva, Miguel Rey, Li, Xiaomo, Onguka, Ouma, Zilbermintz, Leeor, Nguyen, Helen, Falk, Ben A, Olson, Cheryl L, Taylor, Joann M, Epting, Conrad L, Kathayat, Rahul S, Amara, Neri, Dickinson, Bryan C, Bogyo, Matthew, Engman, David M

“…Dynamic post-translational modifications allow the rapid, specific, and tunable regulation of protein functions in eukaryotic cells. -acylation is the only…”
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The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury by Bollyky, Paul L, Bice, Jeffrey B, Sweet, Ian R, Falk, Ben A, Gebe, John A, Clark, April E, Gersuk, Vivian H, Aderem, Alan, Hawn, Thomas R, Nepom, Gerald T

“…Commensal flora and pathogenic microbes influence the incidence of diabetes in animal models yet little is known about the mechanistic basis of these…”
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Regulatory T Cells Resist Cyclosporine-Induced Cell Death via CD44-Mediated Signaling Pathways by Bollyky, Paul L., Long, S. Alice, Falk, Ben A., Ruppert, Shannon M.

“…Cyclosporine A (CSA) is an immunosuppressive agent that specifically targets T cells and also increases the percentage of pro-tolerogenic CD4+Foxp3+ regulatory…”
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Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment by Wang, Zhijun, Kim, So Yeon, Tu, Wei, Kim, Jieun, Xu, Alexander, Yang, Yoon Mee, Matsuda, Michitaka, Reolizo, Lien, Tsuchiya, Takashi, Billet, Sandrine, Gangi, Alexandra, Noureddin, Mazen, Falk, Ben A., Kim, Sungjin, Fan, Wei, Tighiouart, Mourad, You, Sungyong, Lewis, Michael S., Pandol, Stephen J., Di Vizio, Dolores, Merchant, Akil, Posadas, Edwin M., Bhowmick, Neil A., Lu, Shelly C., Seki, Ekihiro

“…Liver metastasis is a major cause of death in patients with colorectal cancer (CRC). Fatty liver promotes liver metastasis, but the underlying mechanism…”
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Evidence for Molecular Mimicry between Human T Cell Epitopes in Rotavirus and Pancreatic Islet Autoantigens by Honeyman, Margo C, Stone, Natalie L, Falk, Ben A, Nepom, Gerald, Harrison, Leonard C

“…In type 1 diabetes, insulin-producing beta cells in the islets of the pancreas are destroyed by autoreactive T cells. Rotavirus (RV) has been implicated in the…”
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Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation, Despite Immunosuppression, Is Associated With Autoantibodies and Pathogenic Autoreactive CD4 T-Cells by VENDRAME, Francesco, PILEGGI, Antonello, ICHII, Hirohito, TAKAHASHI, Hidenori, SNOWHITE, Isaac, ZHIBIN CHEN, MENDEZ, Armando, LINDA CHEN, SAGESHIMA, Junichiro, RUIZ, Phillip, CIANCIO, Gaetano, RICORDI, Camillo, LAUGHLIN, Elsa, REIJONEN, Helena, NEPOM, Gerald T, BURKE, George W, PUGLIESE, Alberto, ALLENDE, Gloria, MARTIN-PAGOLA, Ainhoa, MOLANO, R. Damaris, DIAMANTOPOULOS, Stavros, STANDIFER, Nathan, GEUBTNER, Kelly, FALK, Ben A

“…To investigate if recurrent autoimmunity explained hyperglycemia and C-peptide loss in three immunosuppressed simultaneous pancreas-kidney (SPK) transplant…”
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Crosstalk Between T Lymphocytes and Lung Fibroblasts: Generation of a Hyaluronan‐Enriched Extracellular Matrix Adhesive for Monocytes by Gaucherand, Léa, Falk, Ben A., Evanko, Stephen P., Workman, Gail, Chan, Christina K., Wight, Thomas N.

“…ABSTRACT In immunity and inflammation, T cells are often associated with stromal mesenchymal cells such as fibroblasts. Hyaluronan and proteins that associate…”
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Low‐avidity recognition by CD4+ T cells directed to self‐antigens by Gebe, John A., Falk, Ben A., Rock, Kellee A., Kochik, Sharon A., Heninger, Anne K., Reijonen, Helena, Kwok, William W., Nepom, Gerald T.

“…Self‐reactive T cells populate the peripheral immune system, and likely form the reservoir from which autoreactive cells are derived. We analyzed a panel of…”
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IL-10 Induction from Implants Delivering Pancreatic Islets and Hyaluronan by Bollyky, Paul L., Vernon, Robert B., Falk, Ben A., Preisinger, Anton, Gooden, Michel D., Nepom, Gerald T., Gebe, John A.

“…Local induction of pro-tolerogenic cytokines, such as IL-10, is an appealing strategy to help facilitate transplantation of islets and other tissues. Here, we…”
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CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta by Bollyky, Paul L, Falk, Ben A, Long, S Alice, Preisinger, Anton, Braun, Kathy R, Wu, Rebecca P, Evanko, Stephen P, Buckner, Jane H, Wight, Thomas N, Nepom, Gerald T

“…Work by our group and others has demonstrated a role for the extracellular matrix receptor CD44 and its ligand hyaluronan in CD4(+)CD25(+) regulatory T cell…”
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Cover Image, Volume 118, Number 8, August 2017 by Gaucherand, Léa, Falk, Ben A., Evanko, Stephen P., Workman, Gail, Chan, Christina K., Wight, Thomas N.

“…Cover: The cover image, by Léa Gaucherand et al., is based on the Article Crosstalk Between T Lymphocytes and Lung Fibroblasts: Generation of a…”
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Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide by Steere, Allen C, Klitz, William, Drouin, Elise E, Falk, Ben A, Kwok, William W, Nepom, Gerald T, Baxter-Lowe, Lee Ann

“…An association has previously been shown between antibiotic-refractory Lyme arthritis, the human histocompatibility leukocyte antigen (HLA)-DR4 molecule, and T…”
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Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice by Gebe, John A., Unrath, Kellee A, Falk, Ben A., Ito, Kouichi, Wen, Li, Daniels, Terri L., Lernmark, Åke, Nepom, Gerald T.

“…We have identified for the first time an age-dependent spontaneous loss of tolerance to two self-antigenic epitopes derived from putative diabetes-associated…”
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The insulin A-chain epitope recognized by human T cells is posttranslationally modified by Mannering, Stuart I, Harrison, Leonard C, Williamson, Nicholas A, Morris, Jessica S, Thearle, Daniel J, Jensen, Kent P, Kay, Thomas W H, Rossjohn, Jamie, Falk, Ben A, Nepom, Gerald T, Purcell, Anthony W

“…The autoimmune process that destroys the insulin-producing pancreatic beta cells in type 1 diabetes (T1D) is targeted at insulin and its precursor, proinsulin…”
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