Search Results - "Falk, Ben"

Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment by Wang, Zhijun, Kim, So Yeon, Tu, Wei, Kim, Jieun, Xu, Alexander, Yang, Yoon Mee, Matsuda, Michitaka, Reolizo, Lien, Tsuchiya, Takashi, Billet, Sandrine, Gangi, Alexandra, Noureddin, Mazen, Falk, Ben A., Kim, Sungjin, Fan, Wei, Tighiouart, Mourad, You, Sungyong, Lewis, Michael S., Pandol, Stephen J., Di Vizio, Dolores, Merchant, Akil, Posadas, Edwin M., Bhowmick, Neil A., Lu, Shelly C., Seki, Ekihiro

“…Liver metastasis is a major cause of death in patients with colorectal cancer (CRC). Fatty liver promotes liver metastasis, but the underlying mechanism…”
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TOI-1136 is a Young, Coplanar, Aligned Planetary System in a Pristine Resonant Chain by Dai, Fei, Masuda, Kento, Beard, Corey, Robertson, Paul, Goldberg, Max, Batygin, Konstantin, Bouma, Luke, Lissauer, Jack J., Knudstrup, Emil, Albrecht, Simon, Howard, Andrew W., Knutson, Heather A., Petigura, Erik A., Weiss, Lauren M., Isaacson, Howard, Kristiansen, Martti Holst, Osborn, Hugh, Wang, Songhu, Wang, Xian-Yu, Behmard, Aida, Greklek-McKeon, Michael, Vissapragada, Shreyas, Batalha, Natalie M., Brinkman, Casey L., Chontos, Ashley, Crossfield, Ian, Dressing, Courtney, Fetherolf, Tara, Fulton, Benjamin, Hill, Michelle L., Huber, Daniel, Kane, Stephen R., Lubin, Jack, MacDougall, Mason, Mayo, Andrew, Močnik, Teo, Akana Murphy, Joseph M., Rubenzahl, Ryan A., Scarsdale, Nicholas, Tyler, Dakotah, Zandt, Judah Van, Polanski, Alex S., Schwengeler, Hans Martin, Terentev, Ivan A., Benni, Paul, Bieryla, Allyson, Ciardi, David, Falk, Ben, Furlan, E., Girardin, Eric, Guerra, Pere, Hesse, Katharine M., Howell, Steve B., Lillo-Box, J., Matthews, Elisabeth C., Twicken, Joseph D., Villaseñor, Joel, Latham, David W., Jenkins, Jon M., Ricker, George R., Seager, Sara, Vanderspek, Roland, Winn, Joshua N.

“…Abstract Convergent disk migration has long been suspected to be responsible for forming planetary systems with a chain of mean-motion resonances (MMRs)…”
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Crosstalk Between T Lymphocytes and Lung Fibroblasts: Generation of a Hyaluronan‐Enriched Extracellular Matrix Adhesive for Monocytes by Gaucherand, Léa, Falk, Ben A., Evanko, Stephen P., Workman, Gail, Chan, Christina K., Wight, Thomas N.

“…ABSTRACT In immunity and inflammation, T cells are often associated with stromal mesenchymal cells such as fibroblasts. Hyaluronan and proteins that associate…”
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Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis by Nagy, Nadine, Kaber, Gernot, Johnson, Pamela Y, Gebe, John A, Preisinger, Anton, Falk, Ben A, Sunkari, Vivekananda G, Gooden, Michel D, Vernon, Robert B, Bogdani, Marika, Kuipers, Hedwich F, Day, Anthony J, Campbell, Daniel J, Wight, Thomas N, Bollyky, Paul L

“…We recently reported that abundant deposits of the extracellular matrix polysaccharide hyaluronan (HA) are characteristic of autoimmune insulitis in patients…”
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Bat wing sensors support flight control by Sterbing-D'Angelo, Susanne, Chadha, Mohit, Chiu, Chen, Falk, Ben, Xian, Wei, Barcelo, Janna, Zook, John M, Moss, Cynthia F

“…Bats are the only mammals capable of powered flight, and they perform impressive aerial maneuvers like tight turns, hovering, and perching upside down. The bat…”
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Optimal Localization by Pointing Off Axis by Yovel, Yossi, Falk, Ben, Moss, Cynthia F, Ulanovsky, Nachum

“…Is centering a stimulus in the field of view an optimal strategy to localize and track it? We demonstrated, through experimental and computational studies,…”
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Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue by Martinez, Hunter A., Koliesnik, Ievgen, Kaber, Gernot, Reid, Jacqueline K., Nagy, Nadine, Barlow, Graham, Falk, Ben A., Medina, Carlos O., Hargil, Aviv, Zihsler, Svenja, Vlodavsky, Israel, Li, Jin-Ping, Pérez-Cruz, Magdiel, Tang, Sai-Wen, Meyer, Everett H., Wrenshall, Lucile E., Lord, James D., Garcia, K. Christopher, Palmer, Theo D., Steinman, Lawrence, Nepom, Gerald T., Wight, Thomas N., Bollyky, Paul L., Kuipers, Hedwich F.

“…Although FOXP3 + regulatory T cells (Treg) depend on IL-2 produced by other cells for their survival and function, the levels of IL-2 in inflamed tissue are…”
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Evidence for Molecular Mimicry between Human T Cell Epitopes in Rotavirus and Pancreatic Islet Autoantigens by Honeyman, Margo C, Stone, Natalie L, Falk, Ben A, Nepom, Gerald, Harrison, Leonard C

“…In type 1 diabetes, insulin-producing beta cells in the islets of the pancreas are destroyed by autoreactive T cells. Rotavirus (RV) has been implicated in the…”
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ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors by Bollyky, Paul L., Wu, Rebecca P., Falk, Ben A., Lord, James D., Long, S. Alice, Preisinger, Anton, Teng, Brandon, Holt, Gregory E., Standifer, Nathan E., Braun, Kathleen R., Xie, Cindy Fang, Samuels, Peter L., Vernon, Robert B., Gebe, John A., Wight, Thomas N., Nepom, Gerald T., Germain, Ron

“…We describe a role for ECM as a biosensor for inflammatory microenvironments that plays a critical role in peripheral immune tolerance. We show that hyaluronan…”
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Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation, Despite Immunosuppression, Is Associated With Autoantibodies and Pathogenic Autoreactive CD4 T-Cells by VENDRAME, Francesco, PILEGGI, Antonello, ICHII, Hirohito, TAKAHASHI, Hidenori, SNOWHITE, Isaac, ZHIBIN CHEN, MENDEZ, Armando, LINDA CHEN, SAGESHIMA, Junichiro, RUIZ, Phillip, CIANCIO, Gaetano, RICORDI, Camillo, LAUGHLIN, Elsa, REIJONEN, Helena, NEPOM, Gerald T, BURKE, George W, PUGLIESE, Alberto, ALLENDE, Gloria, MARTIN-PAGOLA, Ainhoa, MOLANO, R. Damaris, DIAMANTOPOULOS, Stavros, STANDIFER, Nathan, GEUBTNER, Kelly, FALK, Ben A

“…To investigate if recurrent autoimmunity explained hyperglycemia and C-peptide loss in three immunosuppressed simultaneous pancreas-kidney (SPK) transplant…”
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Three Warm Jupiters around Solar-analog Stars Detected with TESS by Eberhardt, Jan, Hobson, Melissa J., Henning, Thomas, Trifonov, Trifon, Brahm, Rafael, Espinoza, Nestor, Jordán, Andrés, Thorngren, Daniel, Burn, Remo, Rojas, Felipe I., Sarkis, Paula, Schlecker, Martin, Tala Pinto, Marcelo, Barkaoui, Khalid, Schwarz, Richard P., Suarez, Olga, Guillot, Tristan, Triaud, Amaury H. M. J., Günther, Maximilian N., Abe, Lyu, Boyle, Gavin, Leiva, Rodrigo, Suc, Vincent, Evans, Phil, Dunckel, Nick, Ziegler, Carl, Falk, Ben, Fong, William, Rudat, Alexander, Shporer, Avi, Striegel, Stephanie, Watanabe, David, Jenkins, Jon M., Seager, Sara, Winn, Joshua N.

“…Abstract We report the discovery and characterization of three giant exoplanets orbiting solar-analog stars, detected by the TESS space mission and confirmed…”
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Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells by Bollyky, Paul L., Falk, Ben A., Wu, Rebecca P., Buckner, Jane H., Wight, Thomas N., Nepom, Gerald T.

“…The authors describe the immunoregulatory contributions of intact versus fragmented hyaluronan, a prominent component of the extracellular matrix. The…”
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TESS Giants Transiting Giants. VI. Newly Discovered Hot Jupiters Provide Evidence for Efficient Obliquity Damping after the Main Sequence by Saunders, Nicholas, Grunblatt, Samuel K., Chontos, Ashley, Dai, Fei, Huber, Daniel, Zhang, Jingwen, Stefánsson, Guđmundur, van Saders, Jennifer L., Winn, Joshua N., Hey, Daniel, Howard, Andrew W., Fulton, Benjamin, Isaacson, Howard, Beard, Corey, Giacalone, Steven, Van Zandt, Judah, Murphey, Joseph M. Akana, Rice, Malena, Blunt, Sarah, Turtelboom, Emma, Dalba, Paul A., Lubin, Jack, Brinkman, Casey, Louden, Emma M., Page, Emma, Watkins, Cristilyn N., Collins, Karen A., Stockdale, Chris, Tan, Thiam-Guan, Schwarz, Richard P., Massey, Bob, Howell, Steve B., Vanderburg, Andrew, Ricker, George R., Jenkins, Jon M., Seager, Sara, Christiansen, Jessie L., Daylan, Tansu, Falk, Ben, Brodheim, Max, Gibson, Steven R., Hill, Grant M., Holden, Bradford, Householder, Aaron, Kaye, Stephen, Laher, Russ R., Lanclos, Kyle, Petigura, Erik A., Roy, Arpita, Rubenzahl, Ryan A., Schwab, Christian, Shaum, Abby P., Sirk, Martin M., Smith, Christopher L., Walawender, Josh, Yeh, Sherry

“…Abstract The degree of alignment between a star’s spin axis and the orbital plane of its planets (the stellar obliquity) is related to interesting and poorly…”
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The TESS–Keck Survey. XIX. A Warm Transiting Sub-Saturn-mass Planet and a Nontransiting Saturn-mass Planet Orbiting a Solar Analog by Hill, Michelle L., Kane, Stephen R., Dalba, Paul A., MacDougall, Mason, Fetherolf, Tara, Li, Zhexing, Pidhorodetska, Daria, Batalha, Natalie M., Crossfield, Ian J. M., Dressing, Courtney, Fulton, Benjamin, Howard, Andrew W., Huber, Daniel, Isaacson, Howard, Petigura, Erik A., Robertson, Paul, Weiss, Lauren M., Behmard, Aida, Beard, Corey, Chontos, Ashley, Dai, Fei, Giacalone, Steven, Hirsch, Lea A., Holcomb, Rae, Lubin, Jack, Mayo, Andrew W., Močnik, Teo, Murphy, Joseph M. Akana, Polanski, Alex S., Rosenthal, Lee J., Rubenzahl, Ryan A., Scarsdale, Nicholas, Turtelboom, Emma V., Van Zandt, Judah, Bieryla, Allyson, Ciardi, David R., Eastman, Jason D., Falk, Ben, Hesse, Katharine M., Latham, David W., Livingston, John, Matson, Rachel A., Matthews, Elisabeth, Ricker, George R., Rudat, Alexander, Schlieder, Joshua E., Seager, S., Winn, Joshua N.

“…Abstract The Transiting Exoplanet Survey Satellite (TESS) continues to increase dramatically the number of known transiting exoplanets, and is optimal for…”
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CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta by Bollyky, Paul L, Falk, Ben A, Long, S Alice, Preisinger, Anton, Braun, Kathy R, Wu, Rebecca P, Evanko, Stephen P, Buckner, Jane H, Wight, Thomas N, Nepom, Gerald T

“…Work by our group and others has demonstrated a role for the extracellular matrix receptor CD44 and its ligand hyaluronan in CD4(+)CD25(+) regulatory T cell…”
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Modified High-Molecular-Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance by Gebe, John A, Yadava, Koshika, Ruppert, Shannon M, Marshall, Payton, Hill, Paul, Falk, Ben A, Sweere, Johanna M, Han, Hongwei, Kaber, Gernot, Harten, Ingrid A, Medina, Carlos, Mikecz, Katalin, Ziegler, Steven F, Balaji, Swathi, Keswani, Sundeep G, Perez, Vinicio A de Jesus, Butte, Manish J, Nadeau, Kari, Altemeier, William A, Fanger, Neil, Bollyky, Paul L

“…The extracellular matrix in asthmatic lungs contains abundant low-molecular-weight hyaluronan, and this is known to promote antigen presentation and allergic…”
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Cover Image, Volume 118, Number 8, August 2017 by Gaucherand, Léa, Falk, Ben A., Evanko, Stephen P., Workman, Gail, Chan, Christina K., Wight, Thomas N.

“…Cover: The cover image, by Léa Gaucherand et al., is based on the Article Crosstalk Between T Lymphocytes and Lung Fibroblasts: Generation of a…”
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Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide by Steere, Allen C, Klitz, William, Drouin, Elise E, Falk, Ben A, Kwok, William W, Nepom, Gerald T, Baxter-Lowe, Lee Ann

“…An association has previously been shown between antibiotic-refractory Lyme arthritis, the human histocompatibility leukocyte antigen (HLA)-DR4 molecule, and T…”
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The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury by Bollyky, Paul L, Bice, Jeffrey B, Sweet, Ian R, Falk, Ben A, Gebe, John A, Clark, April E, Gersuk, Vivian H, Aderem, Alan, Hawn, Thomas R, Nepom, Gerald T

“…Commensal flora and pathogenic microbes influence the incidence of diabetes in animal models yet little is known about the mechanistic basis of these…”
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Active control of acoustic field-of-view in a biosonar system by Yovel, Yossi, Falk, Ben, Moss, Cynthia F, Ulanovsky, Nachum

“…Active-sensing systems abound in nature, but little is known about systematic strategies that are used by these systems to scan the environment. Here, we…”
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