Search Results - "Falconer, Isaac"

Flexibility and Solvation of Amyloid-β Hydrophobic Core by Vugmeyster, Liliya, Clark, Matthew A., Falconer, Isaac B., Ostrovsky, Dmitry, Gantz, Donald, Qiang, Wei, Hoatson, Gina L.

“…Amyloid fibril deposits found in Alzheimer disease patients are composed of amyloid-β (Aβ) protein forming a number of hydrophobic interfaces that are believed…”
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Fast Motions of Key Methyl Groups in Amyloid-β Fibrils by Vugmeyster, Liliya, Ostrovsky, Dmitry, Clark, Matthew A., Falconer, Isaac B., Hoatson, Gina L., Qiang, Wei

“…Amyloid-β (Aβ) peptide is the major component of plaques found in Alzheimer’s disease patients. Using solid-state 2H NMR relaxation performed on selectively…”
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LEX-BADAT: Language EXperience in Bilinguals With and Without Aphasia DATaset by Marte, Manuel Jose, Carpenter, Erin, Falconer, Isaac B., Scimeca, Michael, Abdollahi, Fatemeh, Peñaloza, Claudia, Kiran, Swathi

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Solvent-Driven Dynamical Crossover in the Phenylalanine Side-Chain from the Hydrophobic Core of Amyloid Fibrils Detected by 2 H NMR Relaxation by Vugmeyster, Liliya, Ostrovsky, Dmitry, Hoatson, Gina L, Qiang, Wei, Falconer, Isaac B

“…Aromatic residues are important markers of dynamical changes in proteins' hydrophobic cores. In this work we investigated the dynamics of the F19 side-chain in…”
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Optimized purification of a fusion protein by reversed-phase high performance liquid chromatography informed by the linear solvent strength model by Falconer, Isaac B., Mant, Colin T., McKnight, C. James, Vugmeyster, Liliya, Hodges, Robert

“…•Optimized conditions for separating HP36 from the full fusion protein.•Reversed-phase HPLC using a shallow gradient.•Unexpected elution behavior at shallow…”
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Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell-derived alveolar epithelium by Abo, Kristine M, Sainz de Aja, Julio, Lindstrom-Vautrin, Jonathan, Alysandratos, Konstantinos-Dionysios, Richards, Alexsia, Garcia-de-Alba, Carolina, Huang, Jessie, Hix, Olivia T, Werder, Rhiannon B, Bullitt, Esther, Hinds, Anne, Falconer, Isaac, Villacorta-Martin, Carlos, Jaenisch, Rudolf, Kim, Carla F, Kotton, Darrell N, Wilson, Andrew A

“…Type 2 alveolar epithelial cells (AT2s), facultative progenitor cells of the lung alveolus, play a vital role in the biology of the distal lung. In vitro model…”
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Resting-state brain network connectivity is an independent predictor of responsiveness to language therapy in chronic post-stroke aphasia by Falconer, Isaac, Varkanitsa, Maria, Kiran, Swathi

“…Post-stroke aphasia recovery, especially in the chronic phase, is challenging to predict. Functional integrity of the brain and brain network topology have…”
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Deuteration of nonexchangeable protons on proteins affects their thermal stability, side‐chain dynamics, and hydrophobicity by Nichols, Parker J., Falconer, Isaac, Griffin, Aaron, Mant, Colin, Hodges, Robert, McKnight, Christopher J., Vögeli, Beat, Vugmeyster, Liliya

“…We have investigated the effect of deuteration of non‐exchangeable protons on protein global thermal stability, hydrophobicity, and local flexibility using…”
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Solvent-Driven Dynamical Crossover in the Phenylalanine Side-Chain from the Hydrophobic Core of Amyloid Fibrils Detected by 2H NMR Relaxation by Vugmeyster, Liliya, Ostrovsky, Dmitry, Hoatson, Gina L, Qiang, Wei, Falconer, Isaac B

“…Aromatic residues are important markers of dynamical changes in proteins’ hydrophobic cores. In this work we investigated the dynamics of the F19 side-chain in…”
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Solvent-Driven Dynamical Cross-Over in the Phenylalanine Side-Chain from the Hydrophobic Core of Amyloid Fibrils Detected by 2H NMR Relaxation by Vugmeyster, Liliya, Ostrovsky, Dmitry, Hoatson, Gina L., Qiang, Wei, Falconer, Isaac B.

“…Aromatic residues are important markers of dynamical changes in proteins’ hydrophobic cores. In this work we investigated the dynamics of the F19 side-chain in…”
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Fast Motions of Key Methyl Groups in Amyloid-[Beta] Fibrils by Vugmeyster, Liliya, Ostrovsky, Dmitry, Clark, Matthew A, Falconer, Isaac B, Hoatson, Gina L, Qiang, Wei

“…Amyloid-β (Aβ) peptide is the major component of plaques found in Alzheimer's disease patients. Using solid-state 2H NMR relaxation performed on selectively…”
Get full text