Search Results - "Falco, Angela"
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Trimethylamine-N-Oxide (TMAO)-Induced Impairment of Cardiomyocyte Function and the Protective Role of Urolithin B-Glucuronide
Published in Molecules (Basel, Switzerland) (01-03-2018)“…One of the most recently proposed candidates as a potential trigger for cardiovascular diseases is trimethylamine- -oxide (TMAO). Possible direct effects of…”
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Combined Inhibition of CDK4/6 and PI3K/AKT/mTOR Pathways Induces a Synergistic Anti-Tumor Effect in Malignant Pleural Mesothelioma Cells
Published in Neoplasia (New York, N.Y.) (01-08-2017)“…Malignant pleural mesothelioma (MPM) is a progressive malignancy associated to the exposure of asbestos fibers. The most frequently inactivated tumor…”
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3
Higher-dose venetoclax with measurable residual disease-guided azacitidine discontinuation in newly diagnosed acute myeloid leukemia
Published in Haematologica (Roma) (13-04-2023)“…Venetoclax+azacitidine is the standard of care for newly-diagnosed patients with acute myeloid leukemia (AML) for whom intensive chemotherapy is inappropriate…”
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Third generation EGFR inhibitor osimertinib combined with pemetrexed or cisplatin exerts long-lasting anti-tumor effect in EGFR-mutated pre-clinical models of NSCLC
Published in Journal of experimental & clinical cancer research (28-05-2019)“…The third generation Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) osimertinib has been initially approved for T790M positive…”
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5
A Versatile Bioreactor for Dynamic Suspension Cell Culture. Application to the Culture of Cancer Cell Spheroids
Published in PloS one (04-05-2016)“…A versatile bioreactor suitable for dynamic suspension cell culture under tunable shear stress conditions has been developed and preliminarily tested culturing…”
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Subchronic exposure to titanium dioxide nanoparticles modifies cardiac structure and performance in spontaneously hypertensive rats
Published in Particle and fibre toxicology (24-06-2019)“…Non-communicable diseases, intended as the results of a combination of inherited, environmental and biological factors, kill 40 million people each year,…”
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Evaluation and associated risk factors for neutropenia with venetoclax and obinutuzumab in the treatment of chronic lymphocytic leukemia
Published in Cancer reports (01-05-2022)“…Background The time‐limited combination of venetoclax and obinutuzumab (VenG) was established by the German CLL Study Group in the CLL14 trial for the upfront…”
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Identification of an Epi-metabolic dependency on EHMT2/G9a in T-cell acute lymphoblastic leukemia
Published in Cell death & disease (17-06-2022)“…Genomic studies have identified recurrent somatic alterations in genes involved in DNA methylation and post-translational histone modifications in acute…”
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Imatinib mesylate-induced cardiomyopathy involves resident cardiac progenitors
Published in Pharmacological research (01-01-2018)“…[Display omitted] Cardiovascular complications are included among the systemic effects of tyrosine kinase inhibitor (TKI)-based therapeutic strategies. To test…”
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Development of Biomimetic Alginate/Gelatin/Elastin Sponges with Recognition Properties toward Bioactive Peptides for Cardiac Tissue Engineering
Published in Biomimetics (Basel, Switzerland) (11-12-2020)“…In recent years, there has been an increasing interest toward the covalent binding of bioactive peptides from extracellular matrix proteins on scaffolds as a…”
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The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension
Published in Frontiers in cardiovascular medicine (05-05-2023)“…Adverse drug reactions (ADRs) remain among the leading causes of therapy-resistant hypertension (TRH) and uncontrolled blood pressure (BP). We have recently…”
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A Pharmacovigilance Study on the Safety of Axicabtagene Ciloleucel Based on Spontaneous Reports from the EudraVigilance Database
Published in Biomedicines (01-08-2023)“…During pre-approval clinical trials, the safety of axi-cel, a second-generation CAR-T-cell therapy directed against CD19, which dramatically improved the…”
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Orthogonal proteogenomic analysis identifies the druggable PA2G4-MYC axis in 3q26 AML
Published in Nature communications (04-06-2024)“…The overexpression of the ecotropic viral integration site-1 gene ( EVI1/MECOM ) marks the most lethal acute myeloid leukemia (AML) subgroup carrying…”
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Isolation and Characterization of Circulating Tumor Cells in Squamous Cell Carcinoma of the Lung Using a Non-EpCAM-Based Capture Method
Published in PloS one (16-11-2015)“…The exclusion of circulating tumor cells (CTCs) that have lost epithelial antigens during the epithelial-to-mesenchymal transition (EMT) process by using…”
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Inhibition of Human Malignant Pleural Mesothelioma Growth by Mesenchymal Stromal Cells
Published in Cells (Basel, Switzerland) (08-06-2021)“…Background: Malignant Pleural Mesothelioma (MPM) is an aggressive tumor that has a significant incidence related to asbestos exposure with no effective therapy…”
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Parenchymal and Stromal Cells Contribute to Pro-Inflammatory Myocardial Environment at Early Stages of Diabetes: Protective Role of Resveratrol
Published in Nutrients (16-11-2016)“…Little information is currently available concerning the relative contribution of cardiac parenchymal and stromal cells in the activation of the…”
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Isoprostane formation and inhibition in atherothrombosis
Published in Current opinion in pharmacology (01-04-2005)“…Enhanced oxidant stress plays a pivotal role in the pathogenesis of several conditions such as atherothrombosis, cancer and neurodegeneration. The availability…”
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Determinants of F2-isoprostane biosynthesis and inhibition in man
Published in Chemistry and physics of lipids (01-03-2004)“…Several cardiovascular risk factors are characterized by the coexistence of low-grade inflammation, enhanced oxidative stress and lipid peroxidation. It has…”
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Dataset on the identification of a prognostic radio-immune signature in surgically resected Non Small Cell Lung Cancer
Published in Data in brief (01-08-2020)“…The immune regulation of cancer growth and regression has been underscored by the recent success of immunotherapy. The possibility that immune…”
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Cardioprotection by Targeting the Pool of Resident and Extracardiac Progenitors
Published in Current drug targets (01-08-2015)“…The adult heart has the capacity to generate new myocytes that are markedly enhanced in acute and chronic heart failure of ischemic and non-ischemic origin. In…”
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