Search Results - "Falck, Mari"
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Variability and sex-dependence of hypothermic neuroprotection in a rat model of neonatal hypoxic–ischaemic brain injury: a single laboratory meta-analysis
Published in Scientific reports (02-07-2020)“…Therapeutic hypothermia (HT) is standard care for term infants with hypoxic–ischaemic (HI) encephalopathy. However, the efficacy of HT in preclinical models,…”
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Rectal temperature in the first five hours after hypoxia–ischemia critically affects neuropathological outcomes in neonatal rats
Published in Pediatric research (01-02-2018)“…Background Hyperthermia after hypoxia–ischemia (HI) in newborn infants is associated with worse neurological outcomes. Loss of thermoregulation may also be…”
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Correction: Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome - a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)
Published in Current controlled trials in cardiovascular medicine (15-03-2024)Get full text
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Restraint stress during neonatal hypoxia‐ischemia alters brain injury following normothermia and hypothermia
Published in Physiological reports (01-01-2023)“…Rodent models of neonatal hypoxic–ischemic (HI) injury require a subset of animals to be immobilized for continuous temperature monitoring during the insult…”
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Monitoring of cerebral blood flow during hypoxia‐ischemia and resuscitation in the neonatal rat using laser speckle imaging
Published in Physiological reports (01-04-2016)“…Neonatal hypoxic‐ischemic encephalopathy (HIE) is associated with alterations in cerebral blood flow (CBF) as a result of perinatal asphyxia. The extent to…”
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Treatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia
Published in Scientific reports (21-03-2016)“…Therapeutic hypothermia (HT) is standard care for moderate and severe neonatal hypoxic-ischaemic encephalopathy (HIE), the leading cause of permanent brain…”
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Hypothermic Neuronal Rescue from Infection-Sensitised Hypoxic-Ischaemic Brain Injury Is Pathogen Dependent
Published in Developmental neuroscience (01-01-2017)“…Perinatal infection increases the vulnerability of the neonatal brain to hypoxic-ischaemic (HI) injury. Hypothermia treatment (HT) does not provide…”
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Hypothermia Does Not Reverse Cellular Responses Caused by Lipopolysaccharide in Neonatal Hypoxic-Ischaemic Brain Injury
Published in Developmental neuroscience (01-01-2015)“…Bacterial lipopolysaccharide (LPS) injection prior to hypoxia-ischaemia significantly increases hypoxia-ischaemic brain injury in 7-day-old (P7) rats. In…”
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Hypothermia Is Neuroprotective after Severe Hypoxic-Ischaemic Brain Injury in Neonatal Rats Pre-Exposed to PAM3CSK4
Published in Developmental neuroscience (2018)“…Preclinical research on the neuroprotective effect of hypothermia (HT) after perinatal asphyxia has shown variable results, depending on comorbidities and…”
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Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome - a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)
Published in Current controlled trials in cardiovascular medicine (24-01-2024)“…Despite therapeutic hypothermia (TH) and neonatal intensive care, 45-50% of children affected by moderate-to-severe neonatal hypoxic-ischemic encephalopathy…”
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