Search Results - "Falck, J.R"

Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism by Marowsky, A, Burgener, J, Falck, J.R, Fritschy, J.-M, Arand, M

“…Abstract Epoxide hydrolases comprise a family of enzymes important in detoxification and conversion of lipid signaling molecules, namely epoxyeicosatrienoic…”
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The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture by Terashvili, M, Sarkar, P, Nostrand, M.V, Falck, J.R, Harder, D.R

“…Highlights ► 14,15-EET protects dopaminergic neurons from H2 O2 -induced cell death. ► Co-culture of these neurons with astrocytes and astrocyte-conditioned…”
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Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension by Capdevila, J.H., Falck, J.R., Imig, J.D.

“…Studies of the cytochrome P450 arachidonic acid (AA) monooxygenase, now established as a major pathway for the bioactivation of this physiological important…”
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Purification, Sequencing, and Molecular Identification of a Mammalian PP-InsP5 Kinase That Is Activated When Cells Are Exposed to Hyperosmotic Stress by Choi, Jae H., Williams, Jason, Cho, Jaiesoon, Falck, J.R., Shears, Stephen B.

“…Mammalian cells utilize multiple signaling mechanisms to protect against the osmotic stress that accompanies plasma membrane ion transport, solute uptake, and…”
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Structural Analysis and Detection of Biological Inositol Pyrophosphates Reveal That the Family of VIP/Diphosphoinositol Pentakisphosphate Kinases Are 1/3-Kinases by Lin, Hongying, Fridy, Peter C., Ribeiro, Anthony A., Choi, Jae H., Barma, Deb K., Vogel, Günter, Falck, J.R., Shears, Stephen B., York, John D., Mayr, Georg W.

“…We have characterized the positional specificity of the mammalian and yeast VIP/diphosphoinositol pentakisphosphate kinase (PPIP5K) family of inositol…”
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Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells by Katragadda, D, Batchu, S.N, Cho, W.J, Chaudhary, K.R, Falck, J.R, Seubert, J.M

“…Abstract Epoxyeicosatrienoic acids (EETs) are polyunsaturated fatty acids synthesized from arachidonic acid by CYP2J2 epoxygenase and inactivated by soluble…”
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Epoxyeicosatrienoic acid prevents postischemic electrocardiogram abnormalities in an isolated heart model by Batchu, S.N, Law, E, Brocks, D.R, Falck, J.R, Seubert, J.M

“…Abstract Cytochrome P450 epoxygenases metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs) which are in turn converted to…”
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14,15-Epoxyeicosa-5(Z)-enoic Acid: A Selective Epoxyeicosatrienoic Acid Antagonist That Inhibits Endothelium-Dependent Hyperpolarization and Relaxation in Coronary Arteries by Gauthier, Kathryn M, Deeter, Christina, Krishna, U Murali, Reddy, Y Krishna, Bondlela, Muralidhar, Falck, J R, Campbell, William B

“…Endothelium-dependent hyperpolarization and relaxation of vascular smooth muscle are mediated by endothelium-derived hyperpolarizing factors (EDHFs). EDHF…”
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The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity by Patel, Sachin, Carrier, Erica J., Ho, W-S. Vanessa, Rademacher, David J., Cunningham, Sonya, Reddy, D. Sudarshan, Falck, J.R., Cravatt, Benjamin F., Hillard, Cecilia J.

“…N-Arachidonylethanolamine (AEA) accumulates during brain injury and postmortem. Because fatty acid amide hydrolase (FAAH) regulates brain AEA content, the…”
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WX-III-287-19 A Possible Thromboxane Antagonist in Bovine Coronary Arteries by Shah, A.J, Gauthier, K.M, Imig, J.D, Falck, J.R, Campbell, W.B

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A soluble epoxide hydrolase inhibitor—8-HUDE increases pulmonary vasoconstriction through inhibition of KATP channels by Liu, Yun, Zhang, Jing, Yu, Lei, Cao, Fangyuan, Rao, Jingjing, Li, Jing, Jiang, Chun, Falck, J.R, Jacobs, Elizabeth R, Zhu, Daling

“…Abstract Epoxyeicosatrienoic acids (EETs), cytochrome P450-derived metabolites of arachidonic acid, are endogenously produced epoxides that act as substrates…”
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An economic and practical synthesis of the 2-tetrahydrofuranyl ether protective group by Falck, J.R., Li, De Run, Bejot, Romain, Mioskowski, Charles

“…A wide variety of alcohols are efficiently transformed into the corresponding 2-tetrahydrofuranyl ethers by a combination of Mn(0) powder and CCl 4 in…”
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A mechanistic study of the chromium(II)-mediated transformations of trichloromethyl alkyls and carbinols: evidence for carbene, carbyne, and carbenoid intermediates by Bejot, Romain, Tisserand, Steve, Li, De Run, Falck, J.R., Mioskowski, Charles

“…Using CrCl 2 in THF at room temperature, trichloromethyl carbinols and trichloromethylalkanes are readily transformed to the highly reactive α-chlorocarbenes,…”
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Determination of trans-arachidonic acid isomers in human blood plasma by Zghibeh, Chaza M., Raj Gopal, V., Poff, Candace D., Falck, J.R., Balazy, Michael

“…Endogenous trans fatty acids originate from diet, but recent studies also suggest that cis–trans isomerization of fatty acids is possible by nitrogen dioxide…”
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Molecular Cloning, Expression and Characterization of an Endogenous Human Cytochrome P450 Arachidonic Acid Epoxygenase Isoform by Zeldin, D.C., Dubois, R.N., Falck, J.R., Capdevila, J.H.

“…A cDNA containing an open reading frame coding for a human cytochrome P450 arachidonic acid epoxygenase was isolated from a male human kidney cDNA library…”
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The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C by Derman, Melanie P., Toker, Alex, Hartwig, John H., Spokes, Katherine, Falck, J.R., Chen, Ching-Shih, Cantley, Lewis C., Cantley, Lloyd G.

“…Phosphoinositide 3-kinase has been implicated as an activator of cell motility in a variety of recent studies, yet the role of its lipid product,…”
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Asymmetric synthesis of the stereoisomers of 11,12,15( S)-trihydroxyeicosa-5( Z),8( Z),13( E)-trienoic acid, a potent endothelium-derived vasodilator by Falck, J.R., Barma, Deb, Mohapatra, Suchismita, Bandyopadhyay, A., Reddy, Komandla Malla, Qi, Jianjun, Campbell, William

“…The four stereoisomers 11,12,15( S)-THETA were prepared by a triply convergent, asymmetric route that exploited the stereospecific, copper mediated…”
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A convenient synthesis of ( Z)-1-chloro-1-alkenes and ( Z)-1-chloro-2-alkoxy-1-alkenes by Baati, Rachid, Barma, D.K., Krishna, U.Murali, Mioskowski, Charles, Falck, J.R.

“…Mild, room temperature CrCl 2 reduction of 1,1,1-trichloroalkanes stereoselectively generates ( Z)-1-chloro-2-substituted-1-alkenes in excellent yields. Mild…”
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Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase by ZELDIN, D. C, KOBAYASHI, J, FALCK, J. R, WINDER, B. S, HAMMOCK, B. D, SNAPPER, J. R, CAPDEVILA, J. H

“…The hydration of cis-epoxyeicosatrienoic acids to the corresponding vic-dihydroxyeicosatrienoic acids by cytosolic epoxide hydrolase demonstrates moderate…”
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Synthesis of curacin A, an antimitotic cyclopropane-thiazoline from the marine cyanobacterium Lyngbya majuscula by Lai, Jing-Yu, Yu, Jurong, Mekonnen, Belew, Falck, J.R.

“…Charette asymmetric cyclopropanation, chiral thiazoline synthesis by thioamide cyclization under modified Mitsunobu conditions, Ti( iPrO) 4/bi-naphthol…”
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