Search Results - "Falany, Charles N."

High Accuracy in Silico Sulfotransferase Models by Cook, Ian, Wang, Ting, Falany, Charles N., Leyh, Thomas S.

“…Predicting enzymatic behavior in silico is an integral part of our efforts to understand biology. Hundreds of millions of compounds lie in targeted in silico…”
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Regulation of the cytosolic sulfotransferases by nuclear receptors by Runge-Morris, Melissa, Kocarek, Thomas A., Falany, Charles N.

“…The cytosolic sulfotransferases (SULTs) are a multigene family of enzymes that catalyze the transfer of a sulfonate group from the physiologic sulfate donor,…”
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Sulfotransferase 4A1 activity facilitates sulfate-dependent cellular protection to oxidative stress by Brettrager, Evan J., Meehan, Arthur W., Falany, Charles N., van Waardenburg, Robert C. A. M.

“…Sulfotransferase 4A1 (SULT4A1) is an orphan member of the cytosolic SULT superfamily that contains enzymes that catalyze the sulfonation of hydrophobic drugs…”
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Generation and Characterization of SULT4A1 Mutant Mouse Models by Garcia, Patrick L, Hossain, Mohammed I, Andrabi, Shaida A, Falany, Charles N

“…Sulfotransferase 4A1 (SULT4A1) belongs to the cytosolic sulfotransferase (SULT) superfamily of enzymes that catalyze sulfonation reactions with a variety of…”
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Structural plasticity in the human cytosolic sulfotransferase dimer and its role in substrate selectivity and catalysis by Tibbs, Zachary E., Rohn-Glowacki, Katie Jo, Crittenden, Frank, Guidry, Amber L., Falany, Charles N.

“…The cytosolic sulfotransferases (SULTs) are dimeric enzymes that help maintain homeostasis through the modulation of hormone and drug activity by catalyzing…”
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N-terminal domain of tyrosyl-DNA phosphodiesterase I regulates topoisomerase I-induced toxicity in cells by Brettrager, Evan J., Cuya, Selma M., Tibbs, Zachary E., Zhang, Jun, Falany, Charles N., Aller, Stephen G., van Waardenburg, Robert C. A. M.

“…Tyrosyl-DNA phosphodiesterase I (Tdp1) hydrolyzes phosphodiester-linked adducts from both ends of DNA. This includes the topoisomerase I (TOP1)-DNA covalent…”
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24-Hydroxycholesterol Sulfation by Human Cytosolic Sulfotransferases: Formation of Monosulfates and Disulfates, Molecular Modeling, Sulfatase Sensitivity, and Inhibition of Liver X Receptor Activation by COOK, Ian T, DUNIEC-DMUCHOWSKI, Zofia, KOCAREK, Thomas A, RUNGE-MORRIS, Melissa, FALANY, Charles N

“…24-Hydroxycholesterol (24-OHChol) is a major cholesterol metabolite and the form in which cholesterol is secreted from the brain. 24-OHChol is transported by…”
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Carboxy-terminal mutations of bile acid CoA:N-acyltransferase alter activity and substrate specificity by Styles, Nathan A., Shonsey, Erin M., Falany, Josie L., Guidry, Amber L., Barnes, Stephen, Falany, Charles N.

“…Bile acid CoA:amino acid N-acyltransferase (BAAT) is the terminal enzyme in the synthesis of bile salts from cholesterol and catalyzes the conjugation of…”
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Triclosan as A substrate and inhibitor of 3'-phosphoadenosine 5'-phosphosulfate-sulfotransferase and udp-glucuronosyl transferase in human liver fractions by WANG, Li-Quan, FALANY, Charles N, JAMES, Margaret O

“…Triclosan is a broad spectrum antibacterial agent used in many household products. Due to its structural similarity to polychlorobiphenylols, which are potent…”
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Expression and Localization of Cytosolic Sulfotransferase (SULT) 1A1 and SULT1A3 in Normal Human Brain by SALMAN, Emily D, KADLUBAR, Susan A, FALANY, Charles N

“…Cytosolic sulfotransferases (SULTs) are a family of Phase II drug-metabolizing enzymes that catalyze the transfer of a sulfonate group from…”
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A high frequency missense SULT1B1 allelic variant (L145V) selectively expressed in African descendants exhibits altered kinetic properties by Tibbs, Zachary E., Guidry, Amber L., Falany, Josie L., Kadlubar, Susan A., Falany, Charles N.

“…1. Human cytosolic sulfotransferase 1B1 (SULT1B1) sulfates small phenolic compounds and bioactivates polycyclic aromatic hydrocarbons. To date, no SULT1B1…”
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Expression of sulfotransferases and sulfatases in human breast cancer: Impact on resveratrol metabolism by Miksits, Michaela, Wlcek, Katrin, Svoboda, Martin, Thalhammer, Theresia, Ellinger, Isabella, Stefanzl, Gabriele, Falany, Charles N, Szekeres, Thomas, Jaeger, Walter

“…Abstract Resveratrol is a naturally occurring anticancer compound present in grapes and wine that undergoes pronounced metabolism in human intestine and liver…”
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Inhibition of SULT4A1 expression induces up-regulation of phototransduction gene expression in 72-hour postfertilization zebrafish larvae by Crittenden, Frank, Thomas, Holly, Ethen, Cheryl M, Wu, Zhengliang L, Chen, Dongquan, Kraft, Timothy W, Parant, John M, Falany, Charles N

“…Sulfotransferase (SULT) 4A1 is an orphan enzyme that shares distinct structure and sequence similarities with other cytosolic SULTs. SULT4A1 is primarily…”
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Highly selective bioactivation of 1- and 2-hydroxy-3-methylcholanthrene to mutagens by individual human and other mammalian sulphotransferases expressed in Salmonella typhimurium by Meinl, Walter, Tsoi, Carrie, Swedmark, Stellan, Tibbs, Zachary E, Falany, Charles N, Glatt, Hansruedi

“…The benzylic alcohols 1- and 2-hydroxy-3-methylcholanthrene (OH-MC) are major primary metabolites of the carcinogen 3-methylcholanthrene (MC). We investigated…”
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Expression of the orphan cytosolic sulfotransferase SULT1C3 in human intestine: characterization of the transcript variant and implications for function by Duniec-Dmuchowski, Zofia, Rondini, Elizabeth A, Tibbs, Zachary E, Falany, Charles N, Runge-Morris, Melissa, Kocarek, Thomas A

“…The cystolic sulfotransferse 1C3 (SULT1C3) gene was identified by computational analysis of the human genome and suggested to contain duplications of its last…”
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Expression, purification and characterization of human cytosolic sulfotransferase (SULT) 1C4 by Guidry, Amber L, Tibbs, Zachary E, Runge-Morris, Melissa, Falany, Charles N

“…Human cytosolic sulfotransferase 1C4 (hSULT1C4) is a dimeric Phase II drug-metabolizing enzyme primarily expressed in the developing fetus. SULTs facilitate…”
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Developmental expression of aryl, estrogen, and hydroxysteroid sulfotransferases in pre- and postnatal human liver by Duanmu, Zhengbo, Weckle, Amy, Koukouritaki, Sevasti B, Hines, Ronald N, Falany, Josie L, Falany, Charles N, Kocarek, Thomas A, Runge-Morris, Melissa

“…Aryl- (SULT1A1), estrogen- (SULT1E1), and hydroxysteroid- (SULT2A1) sulfotransferases (SULTs) are active determinants of xenobiotic detoxication and hormone…”
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Characterization of Proline-Serine-Rich Carboxyl Terminus in Human Sulfotransferase 2B1b: Immunogenicity, Subcellular Localization, Kinetic Properties, and Phosphorylation by DONGNING HE, FALANY, Charles N

“…The human sulfotransferase ( SULT ) 2B1 gene is a member of the SULT2 gene family and encodes two isoforms, SULT2B1a and SULT2B1b. Although messages for both…”
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SULFATION OF RALOXIFENE AND 4-HYDROXYTAMOXIFEN BY HUMAN CYTOSOLIC SULFOTRANSFERASES by FALANY, Josie L, PILLOFF, Daniel E, LEYH, Thomas S, FALANY, Charles N

“…Raloxifene and 4-hydroxytamoxifen (4-OHT) are important estrogen-related drugs used in the treatment of osteoporosis and breast cancer. Sulfation is involved…”
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Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective by Hossain, M. Iqbal, Marcus, Joshua M., Lee, Jun Hee, Garcia, Patrick L., Singh, VinodKumar, Shacka, John J., Zhang, Jianhua, Gropen, Toby I., Falany, Charles N., Andrabi, Shaida A.

“…Stroke is a leading cause of death and disability. The pathophysiological mechanisms associated with stroke are very complex and not fully understood…”
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