Search Results - "Falany, C N"

Pharmacogenetics of human cytosolic sulfotransferases by Nowell, S, Falany, C N

“…Cytosolic sulfotransferases (SULTs) are phase II detoxification enzymes that are involved in the biotransformation of a wide variety of structurally diverse…”
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Human cytosolic sulfotransferase 2B1: Isoform expression, tissue specificity and subcellular localization by Falany, C.N., He, D., Dumas, N., Frost, A.R., Falany, J.L.

“…Sulfation is an important Phase II conjugation reaction involved in the synthesis and metabolism of steroids in humans. Two different isoforms (2B1a and 2B1b)…”
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Inactivation of human liver bile acid CoA:amino acid N-acyltransferase by the electrophilic lipid, 4-hydroxynonenal by Shonsey, E.M., Eliuk, S.M., Johnson, M.S., Barnes, S., Falany, C.N., Darley-Usmar, V.M., Renfrow, M.B.

“…The hepatic enzyme bile acid CoA:amino acid N-acyltransferase (BAT) catalyzes the formation of amino acid-conjugated bile acids. In the present study, protein…”
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Expression and characterization of the human 3β-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b) by Meloche, Connie A., Falany, Charles N.

“…The human hydroxysteroid sulfotransferase, dehydroepiandrosterone sulfotransferase (DHEA-ST), is highly expressed in liver and adrenal cortex and displays…”
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Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase by FALANY, C. N, JOHNSON, M. R, BARNES, S, DIASIO, R. B

“…In order to establish whether a single enzyme in human liver was capable of conjugating bile acids with both glycine and taurine, a cDNA encoding human liver…”
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Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines by FALANY, J. L, FALANY, C. N

“…Breast cancers require the presence of estrogens for the maintenance of growth at some time in the course of their development, as does normal breast tissue…”
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Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase by Falany, Charles N., Krasnykh, Victor, Falany, Josie L.

“…A distinct human estrogen sulfotransferase (hEST-1) cDNA has been isolated from a human liver γZap cDNA library using a PCR procedure. The enzymatically active…”
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Sulfation of Thyroid Hormone by Estrogen Sulfotransferase by Kester, M. H. A, van Dijk, C. H, Tibboel, D, Hood, A. M, Rose, N. J. M, Meinl, W, Pabel, U, Glatt, H, Falany, C. N, Coughtrie, M. W. H, Visser, T. J

“…Sulfation is one of the pathways by which thyroid hormone is inactivated. Iodothyronine sulfate concentrations are very high in human fetal blood and amniotic…”
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Cloning and expression of human liver dehydroepiandrosterone sulphotransferase by COMER, K. A, FALANY, J. L, FALANY, C. N

“…Dehydroepiandrosterone sulphotransferase (DHEA-ST) catalyses the 3'-phosphoadenosine 5'-phosphosulphate-dependent sulphation of a wide variety of steroids in…”
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Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase by Wilborn, T W, Comer, K A, Dooley, T P, Reardon, I M, Heinrikson, R L, Falany, C N

“…A cDNA encoding the human liver phenol-sulfating form of phenol sulfotransferase (P-PST) has been isolated and characterized from a lambda Uni-Zap XR human…”
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Bacterial expression and kinetic characterization of the human monoamine-sulfating form of phenol sulfotransferase by Ganguly, T C, Krasnykh, V, Falany, C N

“…The cDNA for the human monoamine-sulfating form of phenol sulfotransferase (hM-PST) was isolated from a T47D human breast carcinoma lambda gt10 cDNA library,…”
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Metabolism of the isoflavones genistein and biochanin A in human breast cancer cell lines by PETERSON, T. G, JI, G.-P, KIRK, M, COWARD, L, FALANY, C. N, BARNES, S

“…There is substantial variation in the growth inhibition of different human breast cancer cell lines by the isoflavones genistein and biochanin A. ZR-75-1 and…”
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The role of metabolism in mammary epithelial cell growth inhibition by the isoflavones genistein and biochanin A by Peterson, T.Greg, Coward, Lori, Kirk, Marion, Falany, Charles N., Barnes, Stephen

“…The basis for the differential sensitivity of cultured normal human mammary epithelial (HME) cells and a transformed human breast cancer MCF-7 cell line to…”
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Sulfation of thyroid hormone by estrogen sulfotransferase by KESTER, M. H. A, VAN DIJK, C. H, VISSER, T. J, TIBBOEL, D, HOOD, A. M, ROSE, N. J. M, MEINL, W, PABEL, U, GLATT, H, FALANY, C. N, COUGHTRIE, M. W. H

“…Sulfation is one of the pathways by which thyroid hormone is inactivated. Iodothyronine sulfate concentrations are very high in human fetal blood and amniotic…”
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Identification of a new subfamily of sulphotransferases: cloning and characterization of canine SULT1D1 by Tsoi, C, Falany, C N, Morgenstern, R, Swedmark, S

“…Sulphation is an important conjugation pathway in drug metabolism that has been studied in several species including humans. However, few studies have been…”
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Enzymology of human cytosolic sulfotransferases by Falany, Charles N.

“…Conjugation of many xenobiotics, drugs, and endogenous compounds with a sulfonate moiety is an important reaction in their biotransformation. Sulfation of…”
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Purification and characterization of human liver dehydroepiandrosterone sulphotransferase by Falany, C N, Vazquez, M E, Kalb, J M

“…A form of sulphotransferase capable of sulphating dehydroepiandrosterone and other steroids was purified from cytosol prepared from human liver…”
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Cloning, expression, and chromosomal localization of mouse liver bile acid CoA:amino acid N-acyltransferase by Falany, C N, Fortinberry, H, Leiter, E H, Barnes, S

“…A mouse liver lambda Zap XR cDNA library was screened using the coding region of human bile acid CoA:amino acid N-acyltransferase (BAT) cDNA as a probe. Ten…”
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Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy by Rubin, Gary L., Harrold, Anthony J., Mills, John A., Falany, Charles N., Coughtrie, Michael W.H.

“…The endometrium plays a key role in reproduction, and this function is tightly regulated by endogenous and xenobiotic steroids. Sulphation, catalysed by…”
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Steroid sulfation by expressed human cytosolic sulfotransferases by Falany, C N, Wheeler, J, Oh, T S, Falany, J L

“…The human cytosolic sulfotransferases (STs), dehydroepiandrosterone sulfotransferase (DHEA-ST) and the phenol-sulfating form of phenol sulfotransferase,…”
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