Temperature induced aggregation in aqueous solution of a series of PEO–PPO–PEO copolymers

Temperature induced aggregation in aqueous solution of a series of PEO–PPO–PEO copolymers

The temperature induced aggregation phenomena of a series of poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) block copolymers (poloxamers) were investigated using dye incorporation UV spectroscopy, over a range of mass concentrations (0.1–15 mg ml −1). Initial experiments were perfor...

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Bibliographic Details
Published in:International journal of pharmaceutics Vol. 174; no. 1; pp. 39 - 46
Main Authors: Gaisford, Simon, Beezer, Anthony E, Mitchell, John C, Bell, Paul C, Fakorede, Faluke, Finnie, Jill K, Williams, Stuart J
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 15-11-1998
Elsevier
Subjects:
Biological and medical sciences
Copolymers
Dye incorporation UV spectroscopy
General pharmacology
Medical sciences
Onset temperature
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Temperature induced aggregation
Temperature maxima
Dye incorporation UV spectroscopy
Copolymers
Temperature maxima
Temperature induced aggregation
Onset temperature
Evaluation
Temperature
Dyes
Pharmaceutical technology
Control release polymer
Drug carrier
Ethylene oxide copolymer
Aggregation
Spectrometry
Investigation method
Poloxamer
Ultraviolet spectrum
Dosage form
Thermal phenomenon
Propylene oxide copolymer
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Summary:The temperature induced aggregation phenomena of a series of poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) block copolymers (poloxamers) were investigated using dye incorporation UV spectroscopy, over a range of mass concentrations (0.1–15 mg ml −1). Initial experiments were performed using two different dyes (1,6-diphenyl-1,3,5-hexatriene (DPH) and I 2) so that the performance of each indicator for studying poloxamer aggregation could be determined. Subsequently, the onset temperatures ( T o) and temperature maxima ( T m) for the aggregation processes of 19 poloxamers were determined, using I 2 as an indicator. The aggregation temperature was observed to be dependent on both molecular mass and solution concentration for polymers comprising the same percent PEO, the aggregation temperature decreasing with increasing mass and/or increasing concentration.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(98)00223-3