Search Results - "Fakhfakh, Mehdi"
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Design and Synthesis of Novel N-Benzylidene Derivatives of 3-Amino-4-imino-3,5-dihydro-4H-chromeno[2,3-d]pyrimidine under Microwave, In Silico ADME Predictions, In Vitro Antitumoral Activities and In Vivo Toxicity
Published in Pharmaceuticals (Basel, Switzerland) (02-04-2024)“…The synthesis of a series of new N-benzylidene derivatives of 3-amino-4-imino-3,5-dihydro-4H-chromeno[2,3-d]pyrimidine 10(a-l) bearing two points of molecular…”
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Microwave assisted practical synthesis of 4-imino-3-phenyl-3,4-dihydro-1H-chromeno[2,3-d]pyrimidine-2(5H)-thione derivatives and exploration of their biological activities
Published in ARKIVOC free online journal of organic chemistry (29-05-2017)“…The synthesis of a series of new 4-imino-3,4-dihydro-1H-chromeno[2,3-d]pyrimidine-2(5H)-thiones 6(a-f) without substituent in C-5 position using microwave…”
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Practical approach to N-benzyl derivatives of 2-amino-8-methoxy-4H-chromene-3-carbonitrile by reductive amination: Exploration of their effects against protein kinases and in silico ADME profiling
Published in Journal of molecular structure (15-02-2023)“…•2-Benzylamino-8-methoxy-4H-chromene-3-carbonitrile.•Reductive amination.•Lipinski's descriptors.•Protein kinase.•HsPim1 inhibitor. The synthesis of…”
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Design and Synthesis of Novel N -Benzylidene Derivatives of 3-Amino-4-imino-3,5-dihydro-4 H -chromeno[2,3- d ]pyrimidine under Microwave, In Silico ADME Predictions, In Vitro Antitumoral Activities and In Vivo Toxicity
Published in Pharmaceuticals (Basel, Switzerland) (02-04-2024)“…The synthesis of a series of new -benzylidene derivatives of 3-amino-4-imino-3,5-dihydro-4 -chromeno[2,3- ]pyrimidine bearing two points of molecular diversity…”
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Design and Synthesis of Novel IN/I-Benzylidene Derivatives of 3-Amino-4-imino-3,5-dihydro-4IH/I-chromeno[2,3-Id/I]pyrimidine under Microwave, IIn Silico/I ADME Predictions, IIn Vitro/I Antitumoral Activities and IIn Vivo/I Toxicity
Published in Pharmaceuticals (Basel, Switzerland) (01-04-2024)“…The synthesis of a series of new N-benzylidene derivatives of 3-amino-4-imino-3,5-dihydro-4H-chromeno[2,3-d]pyrimidine 10(a-l) bearing two points of molecular…”
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The synthesis and optical properties of novel fluorescent iminocoumarins and bis-iminocoumarins: Investigations in the series of urea derivatives
Published in Dyes and pigments (2010)“…The condensation of 3-cyano-7-diethylamino-iminocoumarin with various isocyanates and diisocyanates as C-electrophiles gave a new series of N-substituted…”
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Preparation and optical properties of new fluorescent iminocoumarins: Study of N-acyl-derivatives
Published in Journal of photochemistry and photobiology. A, Chemistry. (2007)“…Six new iminocoumarin dyes, bearing a cyano group at the 3-position and a diethylamino group at the 7-position, were synthesized. These compounds differ by the…”
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Synthesis of New bis-Iminocoumarins by Schmidt Reaction Catalyzed by Ion-Exchange Resins
Published in Synthetic communications (01-06-2003)“…A new synthetic route to bis-iminocoumarins is proposed which involves the synthesis of iminocoumarins from reaction of 2-hydroxybenzaldehydes with…”
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