HYPOGLYCEMIC EFFECT OF TRECULIA AFRICANA DECNE ROOT BARK IN NORMAL AND ALLOXAN-INDUCED DIABETIC RATS

The solvent partitioned purified fractions of the hydro-acetone root bark extract of the African breadfruit ( Treculia africana Decne) were evaluated for hypoglycemic activities in normal and diabetic albino rats. Fasting blood glucose levels were estimated by the use of a glucometer at pre-determin...

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Bibliographic Details
Published in:	African journal of traditional, complementary, and alternative medicines Vol. 4; no. 4; pp. 387 - 391
Main Authors:	Oyelola, O. O, Moody, J. O, Odeniyi, M. A, Fakey, T. O
Format:	Journal Article
Language:	English
Published:	Nigeria African Ethnomedicines Network 10-06-2007 African Networks on Ethnomedicines
Subjects:	Moraceae, hypoglycemic activity, alloxanized albino rats Research Paper Treculia africana hypoglycemic activity Moraceae Treculia africana alloxanized albino rats
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Summary:	The solvent partitioned purified fractions of the hydro-acetone root bark extract of the African breadfruit ( Treculia africana Decne) were evaluated for hypoglycemic activities in normal and diabetic albino rats. Fasting blood glucose levels were estimated by the use of a glucometer at pre-determined intervals after oral administration of the test extracts/fractions. Results revealed that the test fractions have only a slight effect on blood sugar level of normal rats. On short term and chronic administration in diabetic rats however, diethyl ether-soluble (DEF) and the water-soluble (WSF) fractions significantly reduced the fasting blood sugar levels (p<0.05) at differing rates when compared with the control group of animals. The diethyl ether soluble fraction (10 mg kg-1 dose level) was found to exhibit the highest activity giving 69.4% reduction in blood sugar level (at 240 hours) which was in comparable range with the reference standard glibenclamide (0.5 mg kg-1) which reduced blood sugar levels by 65.8% below the initial baseline values.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0189-6016 2505-0044 0189-6016
DOI:	10.4314/ajtcam.v4i4.31233